Rudkin Brian B.
Brian B. Rudkin / DR2 - CNRS
Research interests
Research Director at the CNRS within the Stem Cell and Brain Research Institute (SBRI), Inserm U1208, University of Lyon and Co-Founder, in 2009, of the Joint Laboratory on Neuropathogenesis along with Prof. Chonggang YUAN at East China Normal University (ECNU) in Shanghai, integrated into the Key Laboratory of Brain Functional Genomics at the ECNU in January 2014.
The main objective is the transfer of fundamental discoveries using small antibody mimetics called peptide aptamers, to potential patient benefit in the context of the StemGamE platform.
The present transfer focus: • neurodegenerative diseases - e.g. ALS (Amyotrophic Lateral Sclerosis - Maladie de Charcot) • stimulation of the immune response e.g. for adoptive cell therapy of certain cancers • enhancement of safety of the use of embryonic stem cell-derived cultures for potential therapeutic benefit.
Member of Platforms
Selected Publications of Brian B. Rudkin
Year |
Reference | Title | Authors | Journal | PUB MED | ||
|---|---|---|---|---|---|---|---|
| 1988 | 263(31):15853-6 | Nerve growth factor, a differentiating agent, and epidermal growth factor, a mitogen, increase the activities of different S6 kinases in PC12 cells | Mutoh T, Rudkin BB, Koizumi S, Guroff G | J Biol Chem | - | ||
| 1988 | 85(23):8860-4 | A human 200-kDa protein binds selectively to DNA fragments containing G.T mismatches | Jiricny J, Hughes M, Corman N, Rudkin BB | Proc Natl Acad Sci U S A | - | ||
| 1988 | pp. 273-277, Alan R. Liss, Inc | Correlation between the substrate specificity of a Hela mismatch binding protein and the efficiency of mismatch repair in vivo | Jiricny, J, Rudkin BB, Brown TC, Corman N | Mechanisms and Consequences of DNA Damage Processing | - | ||
| 1986 | 5(4):725-31 | Activation of ribosomal protein S6 phosphorylation during meiotic maturation of Xenopus laevis oocytes: in vitro ordered appearance of S6 phosphopeptides | Martin-Pérez J, Rudkin BB, Siegmann M, Thomas G | EMBO J | - | ||
| 1984 | 217(3):731-41 | Decreased protein-synthetic activity is an early consequence of spermidine depletion in rat hepatoma tissue-culture cells | Rudkin BB, Mamont PS, Seiler N | Biochem J | - | ||
| 1980 | 54(2):127-39 | Kinetics of the association of potential-sensitive dyes with model and energy-transducing membranes: implications for fast probe response times | Smith JC, Frank SJ, Bashford CL, Chance B, Rudkin BB | J Membr Biol | - | ||
| 1977 | 252(10):3194-8 | Lipid-protein interactions in membranes: interaction of phospholipids with respiratory enzymes of Escherichia coli membrane | Esfahani M, Rudkin BB, Cutler CJ, Waldron PE | J Biol Chem | - | ||