Research Director at the CNRS within the Stem Cell and Brain Research Institute (SBRI), Inserm U1208, University of Lyon and Co-Founder, in 2009, of the Joint Laboratory on Neuropathogenesis along with Prof. Chonggang YUAN at East China Normal University (ECNU) in Shanghai, integrated into the Key Laboratory of Brain Functional Genomics at the ECNU in January 2014.
The main objective is the transfer of fundamental discoveries using small antibody mimetics called peptide aptamers, to potential patient benefit in the context of the StemGamE platform.
The present transfer focus: • neurodegenerative diseases - e.g. ALS (Amyotrophic Lateral Sclerosis - Maladie de Charcot) • stimulation of the immune response e.g. for adoptive cell therapy of certain cancers • enhancement of safety of the use of embryonic stem cell-derived cultures for potential therapeutic benefit.
|1999||73(10):8762-70||Possible interactions between the NS-1 protein and tumor necrosis factor alpha pathways in erythroid cell apoptosis induced by human parvovirus B19||Sol N, Le Junter J, Vassias I, Freyssinier JM, Thomas A, Prigent AF, Rudkin BB, Fichelson S, Morinet F||J Virol||-|
|1999||18(18):2872-82||Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation||Billon N, Carlisi D, Datto MB, van Grunsven LA, Watt A, Wang XF, Rudkin BB||Oncogene||-|
|1999||262(1):157-62||Phosphorylation by p44 MAP Kinase/ERK1 stimulates CBP histone acetyl transferase activity in vitro||Ait-Si-Ali S, Carlisi D, Ramirez S, Upegui-Gonzalez LC, Duquet A, Robin P, Rudkin BB, Harel-Bellan A, Trouche D||Biochem Biophys Res Commun||-|
|1999||pp254 - 255. Directorate General Research ed.||Proliferation, Differentiation, Apoptosis : What's the difference?||Rudkin BB||Biomedical and health research programme 1994-1998, Summaries of projects supported under Biomed2, Volume 1||-|
|1999||10(7):1129-38||Retroviral vectors for the expression of two genes in human multipotent neural precursors and their differentiated neuronal and glial progeny||Derrington EA, López-Lastra M, Chapel-Fernandez S, Cosset FL, Belin MF, Rudkin BB, Darlix JL||Hum Gene Ther||-|
|1998||9(15):3409-13||Increased levels of TrkA in the regenerating retinal ganglion cells of fish||Vecino E, Caminos E, Becker E, Rudkin BB, Evan GI, Martín-Zanca D||Neuroreport||-|
|1998||18(17):6767-75||Cell cycle phase-specific surface expression of nerve growth factor receptors TrkA and p75(NTR)||Urdiales JL, Becker E, Andrieu M, Thomas A, Jullien J, van Grunsven LA, Menut S, Evan GI, Martín-Zanca D, Rudkin BB||J Neurosci||-|
|1998||17(13):1663-72||Human primitive neuroectodermal tumour cells behave as multipotent neural precursors in response to FGF2||Derrington EA, Dufay N, Rudkin BB, Belin MF||Oncogene||-|
|1998||16(7):825-32||Specific TrkA survival signals interfere with different apoptotic pathways||Ulrich E, Duwel A, Kauffmann-Zeh A, Gilbert C, Lyon D, Rudkin BB, Evan G, Martin-Zanca D||Oncogene||-|
|1998||pp100 - 106. IOS Press, Amsterdam||Decision-Making in a cell: Proliferation, Differentiation, Apoptosis?||Rudkin BB, Evan GI, Martin-Zanca D||Cancer Research Supported under Biomed1||-|