Research Director at the CNRS within the Stem Cell and Brain Research Institute (SBRI), Inserm U1208, University of Lyon and Co-Founder, in 2009, of the Joint Laboratory on Neuropathogenesis along with Prof. Chonggang YUAN at East China Normal University (ECNU) in Shanghai, integrated into the Key Laboratory of Brain Functional Genomics at the ECNU in January 2014.
The main objective is the transfer of fundamental discoveries using small antibody mimetics called peptide aptamers, to potential patient benefit in the context of the StemGamE platform.
The present transfer focus: • neurodegenerative diseases - e.g. ALS (Amyotrophic Lateral Sclerosis - Maladie de Charcot) • stimulation of the immune response e.g. for adoptive cell therapy of certain cancers • enhancement of safety of the use of embryonic stem cell-derived cultures for potential therapeutic benefit.
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Reference | Title | Authors | Journal | PUB MED | ||
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2009 | 535:373-88 | Peptide aptamers for small molecule drug discovery | Bardou C, Borie C, Bickle M, Rudkin BB, Colas P | Methods Mol Biol | - | ||
2011 | 33:983-987 | Effect of Caveolin-1 on Proliferation and Survival of MCF-7 Breast | Lu R, Ma J, Zhang Y, Lu L, Spencer A, Cluet D, Rudkin BB, Yuan CG | Chin J Cell Biol | - | ||
2012 | 7(7):485-91 | Dorsal root ganglion progenitors differentiate to gamma-aminobutyric acid- and choline acetyltransferase-positive neurons | Yu L, Ding Y, Spencer A, Ma J, Lu R, Rudkin BB, Yuan C | Neural Regen Res | - | ||
2013 | 12(7):1939-52 | Calcineurin A versus NS5A-TP2/HD domain containing 2: a case study of site-directed low-frequency random mutagenesis for dissecting target specificity of peptide aptamers | Dibenedetto S, Cluet D, Stebe PN, Baumle V, Léault J, Terreux R, Bickle M, Chassey BD, Mikaelian I, Colas P, Spichty M, Zoli M, Rudkin BB | Mol Cell Proteomics | - | ||
2014 | 15 Suppl 14:S5 | EXACT2: the semantics of biomedical protocols | Soldatova LN, Nadis D, King RD, Basu PS, Haddi E, Baumlé V, Saunders NJ, Marwan W, Rudkin BB | BMC Bioinformatics | - | ||
2015 | 2;8:2 | Highly efficient method for gene delivery into mouse dorsal root ganglia neurons. | Yu L, Reynaud F, Falk J, Spencer A, Ding YD, Baumlé V, Lu R, Castellani V, Yuan C, Rudkin BB | Front Mol Neurosci | - | ||
2017 | 18(4): 693 | Nerve Growth Factor Signaling from Membrane Microdomains to the Nucleus: Differential Regulation by Caveolins | Spencer A, Yu L, Guilli V, Reynaud F, Ding YD, Jullien J, Koubi D, Gauthier E, Cluet D, Rudkin BB, Falk J, Castellani V, Yuan CG | Int J Mol Sci | - | ||