Research Director at the CNRS within the Stem Cell and Brain Research Institute (SBRI), Inserm U1208, University of Lyon and Co-Founder, in 2009, of the Joint Laboratory on Neuropathogenesis along with Prof. Chonggang YUAN at East China Normal University (ECNU) in Shanghai, integrated into the Key Laboratory of Brain Functional Genomics at the ECNU in January 2014.
The main objective is the transfer of fundamental discoveries using small antibody mimetics called peptide aptamers, to potential patient benefit in the context of the StemGamE platform.
The present transfer focus: • neurodegenerative diseases - e.g. ALS (Amyotrophic Lateral Sclerosis - Maladie de Charcot) • stimulation of the immune response e.g. for adoptive cell therapy of certain cancers • enhancement of safety of the use of embryonic stem cell-derived cultures for potential therapeutic benefit.
|1989||Raven Press, Ltd., New York. 195-202||Nerve growth factor-sensitive phosphorylations and the action of K-252a on PC12 cells||Koizumi S, Mutoh T, Ryazanov A, Rudkin BB, Guroff G||Trophic Factors and the Nervous System||-|
|1991||285(2):170-5||Regulation of protein synthesis at the elongation stage. New insights into the control of gene expression in eukaryotes||Ryazanov AG, Rudkin BB, Spirin AS||FEBS Lett||-|
|1991||3:1-5||To divide or not to divide: When, where and how. Molecular control of the cell cycle and cell differentiation||Rudkin BB||The New Biol||-|
|1991||28(4):486-96||Differentiation of PC12 cells with K-ras: comparison with nerve growth factor||Simpson DL, Dickens G, Doll S, Koizumi S, Tocco M, Okuda O, Oshima M, Rudkin BB, Brightman M, Guroff G||J Neurosci Res||-|
|1992||58(1):175-85||Differential responses of the phosphorylation of ribosomal protein S6 to nerve growth factor and epidermal growth factor in PC12 cells||Mutoh T, Rudkin BB, Guroff G||J Neurochem||-|
|1993||54(3):161-75||Patterns of nerve growth factor (NGF), proNGF, and p75 NGF receptor expression in the rat incisor: comparison with expression in the molar||Mitsiadis TA, Couble P, Dicou E, Rudkin BB, Magloire H||Differentiation||-|
|1994||269(5):3739-44||Nerve growth factor induces transcription of transforming growth factor-beta 1 through a specific promoter element in PC12 cells||Kim SJ, Park K, Rudkin BB, Dey BR, Sporn MB, Roberts AB||J Biol Chem||-|
|1994||A.-E. Baert et al. Ed||Decision-Making in a cell: Proliferation, Differentiation, Apoptosis?||Martin-Zanca D, Evan GI, Rudkin BB||European Union Biomedical and Health Research. The BIOMED 1 Programme||-|
|1996||13(10):2047-54||The CDK inhibitor p21WAF1/Cip1 is induced through a p300-dependent mechanism during NGF-mediated neuronal differentiation of PC12 cells||Billon N, van Grunsven LA, Rudkin BB||Oncogene||-|
|1996||12(4):855-62||Nerve growth factor-induced accumulation of PC12 cells expressing cyclin D1: evidence for a G1 phase block||van Grunsven LA, Thomas A, Urdiales JL, Machenaud S, Choler P, Durand I, Rudkin BB||Oncogene||-|