Rudkin Brian B.
Brian B. Rudkin / DR2 - CNRS
Research interests
Research Director at the CNRS within the Stem Cell and Brain Research Institute (SBRI), Inserm U1208, University of Lyon and Co-Founder, in 2009, of the Joint Laboratory on Neuropathogenesis along with Prof. Chonggang YUAN at East China Normal University (ECNU) in Shanghai, integrated into the Key Laboratory of Brain Functional Genomics at the ECNU in January 2014.
The main objective is the transfer of fundamental discoveries using small antibody mimetics called peptide aptamers, to potential patient benefit in the context of the StemGamE platform.
The present transfer focus: • neurodegenerative diseases - e.g. ALS (Amyotrophic Lateral Sclerosis - Maladie de Charcot) • stimulation of the immune response e.g. for adoptive cell therapy of certain cancers • enhancement of safety of the use of embryonic stem cell-derived cultures for potential therapeutic benefit.
Member of Platforms
Selected Publications of Brian B. Rudkin
| Year | Reference |
Title |
Authors | Journal | PUB MED | ||
|---|---|---|---|---|---|---|---|
| 2007 | 6(12):2110-21 | A comparative analysis of perturbations caused by a gene knock-out, a dominant negative allele, and a set of peptide aptamers | Abed N, Bickle M, Mari B, Schapira M, Sanjuan-España R, Robbe Sermesant K, Moncorgé O, Mouradian-Garcia S, Barbry P, Rudkin BB, Fauvarque MO, Michaud-Soret I, Colas P | Mol Cell Proteomics | - | ||
| 1988 | 85(23):8860-4 | A human 200-kDa protein binds selectively to DNA fragments containing G.T mismatches | Jiricny J, Hughes M, Corman N, Rudkin BB | Proc Natl Acad Sci U S A | - | ||
| 1986 | 5(4):725-31 | Activation of ribosomal protein S6 phosphorylation during meiotic maturation of Xenopus laevis oocytes: in vitro ordered appearance of S6 phosphopeptides | Martin-Pérez J, Rudkin BB, Siegmann M, Thomas G | EMBO J | - | ||
| 2007 | 6(3):451-9 | An antiproliferative genetic screening identifies a peptide aptamer that targets calcineurin and up-regulates its activity | de Chassey B, Mikaelian I, Mathieu AL, Bickle M, Olivier D, Nègre D, Cosset FL, Rudkin BB, Colas P | Mol Cell Proteomics | - | ||
| 2007 | 210(1):51-62 | beta-Nerve growth factor participates in an auto/paracrine pathway of regulation of the meiotic differentiation of rat spermatocytes | Perrard MH, Vigier M, Damestoy A, Chapat C, Silandre D, Rudkin BB, Durand P | J Cell Physiol | - | ||
| 2013 | 12(7):1939-52 | Calcineurin A versus NS5A-TP2/HD domain containing 2: a case study of site-directed low-frequency random mutagenesis for dissecting target specificity of peptide aptamers | Dibenedetto S, Cluet D, Stebe PN, Baumle V, Léault J, Terreux R, Bickle M, Chassey BD, Mikaelian I, Colas P, Spichty M, Zoli M, Rudkin BB | Mol Cell Proteomics | - | ||
| 2007 | 18(12):4899-910 | CD44 and beta3 integrin organize two functionally distinct actin-based domains in osteoclasts | Chabadel A, Bañon-Rodríguez I, Cluet D, Rudkin BB, Wehrle-Haller B, Genot E, Jurdic P, Anton IM, Saltel F | Mol Biol Cell | - | ||
| 1998 | 18(17):6767-75 | Cell cycle phase-specific surface expression of nerve growth factor receptors TrkA and p75(NTR) | Urdiales JL, Becker E, Andrieu M, Thomas A, Jullien J, van Grunsven LA, Menut S, Evan GI, Martín-Zanca D, Rudkin BB | J Neurosci | - | ||
| 1989 | 8(11):3319-25 | Cell cycle-specific action of nerve growth factor in PC12 cells: differentiation without proliferation | Rudkin BB, Lazarovici P, Levi BZ, Abe Y, Fujita K, Guroff G | EMBO J | - | ||
| 1999 | 18(18):2872-82 | Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation | Billon N, Carlisi D, Datto MB, van Grunsven LA, Watt A, Wang XF, Rudkin BB | Oncogene | - | ||