Research Director at the CNRS within the Stem Cell and Brain Research Institute (SBRI), Inserm U1208, University of Lyon and Co-Founder, in 2009, of the Joint Laboratory on Neuropathogenesis along with Prof. Chonggang YUAN at East China Normal University (ECNU) in Shanghai, integrated into the Key Laboratory of Brain Functional Genomics at the ECNU in January 2014.
The main objective is the transfer of fundamental discoveries using small antibody mimetics called peptide aptamers, to potential patient benefit in the context of the StemGamE platform.
The present transfer focus: • neurodegenerative diseases - e.g. ALS (Amyotrophic Lateral Sclerosis - Maladie de Charcot) • stimulation of the immune response e.g. for adoptive cell therapy of certain cancers • enhancement of safety of the use of embryonic stem cell-derived cultures for potential therapeutic benefit.
|1988||263(31):15853-6||Nerve growth factor, a differentiating agent, and epidermal growth factor, a mitogen, increase the activities of different S6 kinases in PC12 cells||Mutoh T, Rudkin BB, Koizumi S, Guroff G||J Biol Chem||-|
|2003||278(10):8706-16||Trafficking of TrkA-green fluorescent protein chimerae during nerve growth factor-induced differentiation||Jullien J, Guili V, Derrington EA, Darlix JL, Reichardt LF, Rudkin BB||J Biol Chem||-|
|1977||252(10):3194-8||Lipid-protein interactions in membranes: interaction of phospholipids with respiratory enzymes of Escherichia coli membrane||Esfahani M, Rudkin BB, Cutler CJ, Waldron PE||J Biol Chem||-|
|2002||277(41):38700-8||Molecular kinetics of nerve growth factor receptor trafficking and activation||Jullien J, Guili V, Reichardt LF, Rudkin BB||J Biol Chem||-|
|1994||269(5):3739-44||Nerve growth factor induces transcription of transforming growth factor-beta 1 through a specific promoter element in PC12 cells||Kim SJ, Park K, Rudkin BB, Dey BR, Sporn MB, Roberts AB||J Biol Chem||-|
|2007||210(1):51-62||beta-Nerve growth factor participates in an auto/paracrine pathway of regulation of the meiotic differentiation of rat spermatocytes||Perrard MH, Vigier M, Damestoy A, Chapat C, Silandre D, Rudkin BB, Durand P||J Cell Physiol||-|
|1980||54(2):127-39||Kinetics of the association of potential-sensitive dyes with model and energy-transducing membranes: implications for fast probe response times||Smith JC, Frank SJ, Bashford CL, Chance B, Rudkin BB||J Membr Biol||-|
|1992||58(1):175-85||Differential responses of the phosphorylation of ribosomal protein S6 to nerve growth factor and epidermal growth factor in PC12 cells||Mutoh T, Rudkin BB, Guroff G||J Neurochem||-|
|1998||18(17):6767-75||Cell cycle phase-specific surface expression of nerve growth factor receptors TrkA and p75(NTR)||Urdiales JL, Becker E, Andrieu M, Thomas A, Jullien J, van Grunsven LA, Menut S, Evan GI, Martín-Zanca D, Rudkin BB||J Neurosci||-|
|1991||28(4):486-96||Differentiation of PC12 cells with K-ras: comparison with nerve growth factor||Simpson DL, Dickens G, Doll S, Koizumi S, Tocco M, Okuda O, Oshima M, Rudkin BB, Brightman M, Guroff G||J Neurosci Res||-|