Rudkin Brian B.
Brian B. Rudkin / DR2 - CNRS
Research interests
Research Director at the CNRS within the Stem Cell and Brain Research Institute (SBRI), Inserm U1208, University of Lyon and Co-Founder, in 2009, of the Joint Laboratory on Neuropathogenesis along with Prof. Chonggang YUAN at East China Normal University (ECNU) in Shanghai, integrated into the Key Laboratory of Brain Functional Genomics at the ECNU in January 2014.
The main objective is the transfer of fundamental discoveries using small antibody mimetics called peptide aptamers, to potential patient benefit in the context of the StemGamE platform.
The present transfer focus: • neurodegenerative diseases - e.g. ALS (Amyotrophic Lateral Sclerosis - Maladie de Charcot) • stimulation of the immune response e.g. for adoptive cell therapy of certain cancers • enhancement of safety of the use of embryonic stem cell-derived cultures for potential therapeutic benefit.
Member of Platforms
Selected Publications of Brian B. Rudkin
Year |
Reference | Title | Authors | Journal | PUB MED | ||
|---|---|---|---|---|---|---|---|
| 2002 | 277(41):38700-8 | Molecular kinetics of nerve growth factor receptor trafficking and activation | Jullien J, Guili V, Reichardt LF, Rudkin BB | J Biol Chem | - | ||
| 2003 | 278(10):8706-16 | Trafficking of TrkA-green fluorescent protein chimerae during nerve growth factor-induced differentiation | Jullien J, Guili V, Derrington EA, Darlix JL, Reichardt LF, Rudkin BB | J Biol Chem | - | ||
| 2004 | 70(4):1147-52 | Key role for cyclin-dependent kinases in the first and second meiotic divisions of rat spermatocytes | Godet M, Damestoy A, Mouradian S, Rudkin BB, Durand P | Biol Reprod | |||
| 2004 | 70(4):1147-52 | Key role for cyclin-dependent kinases in the first and second meiotic divisions of rat spermatocytes | Godet M, Damestoy A, Mouradian S, Rudkin BB, Durand P | Biol Reprod | - | ||
| 2005 | 25(12):5106-18 | Critical role for Kalirin in nerve growth factor signaling through TrkA | Chakrabarti K, Lin R, Schiller NI, Wang Y, Koubi D, Fan YX, Rudkin BB, Johnson GR, Schiller MR | Mol Cell Biol | - | ||
| 2007 | 18(12):4899-910 | CD44 and beta3 integrin organize two functionally distinct actin-based domains in osteoclasts | Chabadel A, Bañon-Rodríguez I, Cluet D, Rudkin BB, Wehrle-Haller B, Genot E, Jurdic P, Anton IM, Saltel F | Mol Biol Cell | - | ||
| 2007 | 6(12):2110-21 | A comparative analysis of perturbations caused by a gene knock-out, a dominant negative allele, and a set of peptide aptamers | Abed N, Bickle M, Mari B, Schapira M, Sanjuan-España R, Robbe Sermesant K, Moncorgé O, Mouradian-Garcia S, Barbry P, Rudkin BB, Fauvarque MO, Michaud-Soret I, Colas P | Mol Cell Proteomics | - | ||
| 2007 | 6(11):1842-54 | Nerve growth factor receptor TrkA signaling in breast cancer cells involves Ku70 to prevent apoptosis | Com E, Lagadec C, Page A, El Yazidi-Belkoura I, Slomianny C, Spencer A, Hammache D, Rudkin BB, Hondermarck H | Mol Cell Proteomics | - | ||
| 2007 | 6(3):451-9 | An antiproliferative genetic screening identifies a peptide aptamer that targets calcineurin and up-regulates its activity | de Chassey B, Mikaelian I, Mathieu AL, Bickle M, Olivier D, Nègre D, Cosset FL, Rudkin BB, Colas P | Mol Cell Proteomics | - | ||
| 2007 | 210(1):51-62 | beta-Nerve growth factor participates in an auto/paracrine pathway of regulation of the meiotic differentiation of rat spermatocytes | Perrard MH, Vigier M, Damestoy A, Chapat C, Silandre D, Rudkin BB, Durand P | J Cell Physiol | - | ||