Research Director at the CNRS within the Stem Cell and Brain Research Institute (SBRI), Inserm U1208, University of Lyon and Co-Founder, in 2009, of the Joint Laboratory on Neuropathogenesis along with Prof. Chonggang YUAN at East China Normal University (ECNU) in Shanghai, integrated into the Key Laboratory of Brain Functional Genomics at the ECNU in January 2014.
The main objective is the transfer of fundamental discoveries using small antibody mimetics called peptide aptamers, to potential patient benefit in the context of the StemGamE platform.
The present transfer focus: • neurodegenerative diseases - e.g. ALS (Amyotrophic Lateral Sclerosis - Maladie de Charcot) • stimulation of the immune response e.g. for adoptive cell therapy of certain cancers • enhancement of safety of the use of embryonic stem cell-derived cultures for potential therapeutic benefit.
|1989||Raven Press, Ltd., New York. 195-202||Nerve growth factor-sensitive phosphorylations and the action of K-252a on PC12 cells||Koizumi S, Mutoh T, Ryazanov A, Rudkin BB, Guroff G||Trophic Factors and the Nervous System||-|
|1999||pp254 - 255. Directorate General Research ed.||Proliferation, Differentiation, Apoptosis : What's the difference?||Rudkin BB||Biomedical and health research programme 1994-1998, Summaries of projects supported under Biomed2, Volume 1||-|
|1998||pp100 - 106. IOS Press, Amsterdam||Decision-Making in a cell: Proliferation, Differentiation, Apoptosis?||Rudkin BB, Evan GI, Martin-Zanca D||Cancer Research Supported under Biomed1||-|
|1988||pp. 273-277, Alan R. Liss, Inc||Correlation between the substrate specificity of a Hela mismatch binding protein and the efficiency of mismatch repair in vivo||Jiricny, J, Rudkin BB, Brown TC, Corman N||Mechanisms and Consequences of DNA Damage Processing||-|
|1994||A.-E. Baert et al. Ed||Decision-Making in a cell: Proliferation, Differentiation, Apoptosis?||Martin-Zanca D, Evan GI, Rudkin BB||European Union Biomedical and Health Research. The BIOMED 1 Programme||-|
|2000||90:113-125||Sensory neurons respond to long-lasting inflammatory pain by directing NGF receptors to their central terminals and enhancing their projection field in deep layers of the dorsal horn||Pezet S, Onténiente, B, Jullien, J, Junier MP, Grannec G, Rudkin BB, Calvino B||Pain||-|
|1998||9(15):3409-13||Increased levels of TrkA in the regenerating retinal ganglion cells of fish||Vecino E, Caminos E, Becker E, Rudkin BB, Evan GI, Martín-Zanca D||Neuroreport||-|
|1988||85(23):8860-4||A human 200-kDa protein binds selectively to DNA fragments containing G.T mismatches||Jiricny J, Hughes M, Corman N, Rudkin BB||Proc Natl Acad Sci U S A||-|
|1989||8(11):3319-25||Cell cycle-specific action of nerve growth factor in PC12 cells: differentiation without proliferation||Rudkin BB, Lazarovici P, Levi BZ, Abe Y, Fujita K, Guroff G||EMBO J||-|
|2000||79(11):816-23||Developmental changes in cyclin B1 and cyclin-dependent kinase 1 (CDK1) levels in the different populations of spermatogenic cells of the post-natal rat testis||Godet M, Thomas A, Rudkin BB, Durand P||Eur J Cell Biol||-|