Rudkin Brian B.
Brian B. Rudkin / DR2 - CNRS
Research interests
Research Director at the CNRS within the Stem Cell and Brain Research Institute (SBRI), Inserm U1208, University of Lyon and Co-Founder, in 2009, of the Joint Laboratory on Neuropathogenesis along with Prof. Chonggang YUAN at East China Normal University (ECNU) in Shanghai, integrated into the Key Laboratory of Brain Functional Genomics at the ECNU in January 2014.
The main objective is the transfer of fundamental discoveries using small antibody mimetics called peptide aptamers, to potential patient benefit in the context of the StemGamE platform.
The present transfer focus: • neurodegenerative diseases - e.g. ALS (Amyotrophic Lateral Sclerosis - Maladie de Charcot) • stimulation of the immune response e.g. for adoptive cell therapy of certain cancers • enhancement of safety of the use of embryonic stem cell-derived cultures for potential therapeutic benefit.
Member of Platforms
Selected Publications of Brian B. Rudkin
| Year |
Reference |
Title | Authors | Journal | PUB MED | ||
|---|---|---|---|---|---|---|---|
| 1997 | 15(4):393-402 | Oncogenic activation of RET by two distinct FMTC mutations affecting the tyrosine kinase domain | Pasini A, Geneste O, Legrand P, Schlumberger M, Rossel M, Fournier L, Rudkin BB, Schuffenecker I, Lenoir GM, Billaud M | Oncogene | - | ||
| 1998 | 16(7):825-32 | Specific TrkA survival signals interfere with different apoptotic pathways | Ulrich E, Duwel A, Kauffmann-Zeh A, Gilbert C, Lyon D, Rudkin BB, Evan G, Martin-Zanca D | Oncogene | - | ||
| 1998 | 17(13):1663-72 | Human primitive neuroectodermal tumour cells behave as multipotent neural precursors in response to FGF2 | Derrington EA, Dufay N, Rudkin BB, Belin MF | Oncogene | - | ||
| 2007 | 18(12):4899-910 | CD44 and beta3 integrin organize two functionally distinct actin-based domains in osteoclasts | Chabadel A, Bañon-Rodríguez I, Cluet D, Rudkin BB, Wehrle-Haller B, Genot E, Jurdic P, Anton IM, Saltel F | Mol Biol Cell | - | ||
| 1998 | 18(17):6767-75 | Cell cycle phase-specific surface expression of nerve growth factor receptors TrkA and p75(NTR) | Urdiales JL, Becker E, Andrieu M, Thomas A, Jullien J, van Grunsven LA, Menut S, Evan GI, Martín-Zanca D, Rudkin BB | J Neurosci | - | ||
| 1999 | 18(18):2872-82 | Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation | Billon N, Carlisi D, Datto MB, van Grunsven LA, Watt A, Wang XF, Rudkin BB | Oncogene | - | ||
| 2017 | 18(4): 693 | Nerve Growth Factor Signaling from Membrane Microdomains to the Nucleus: Differential Regulation by Caveolins | Spencer A, Yu L, Guilli V, Reynaud F, Ding YD, Jullien J, Koubi D, Gauthier E, Cluet D, Rudkin BB, Falk J, Castellani V, Yuan CG | Int J Mol Sci | - | ||
| 2007 | 210(1):51-62 | beta-Nerve growth factor participates in an auto/paracrine pathway of regulation of the meiotic differentiation of rat spermatocytes | Perrard MH, Vigier M, Damestoy A, Chapat C, Silandre D, Rudkin BB, Durand P | J Cell Physiol | - | ||
| 1984 | 217(3):731-41 | Decreased protein-synthetic activity is an early consequence of spermidine depletion in rat hepatoma tissue-culture cells | Rudkin BB, Mamont PS, Seiler N | Biochem J | - | ||
| 1989 | 24(1):49-58 | Differentiation of PC12 cells with v-src: comparison with nerve growth factor | Rausch DM, Dickens G, Doll S, Fujita K, Koizumi S, Rudkin BB, Tocco M, Eiden LE, Guroff G | J Neurosci Res | - | ||