Research Director at the CNRS within the Stem Cell and Brain Research Institute (SBRI), Inserm U1208, University of Lyon and Co-Founder, in 2009, of the Joint Laboratory on Neuropathogenesis along with Prof. Chonggang YUAN at East China Normal University (ECNU) in Shanghai, integrated into the Key Laboratory of Brain Functional Genomics at the ECNU in January 2014.
The main objective is the transfer of fundamental discoveries using small antibody mimetics called peptide aptamers, to potential patient benefit in the context of the StemGamE platform.
The present transfer focus: • neurodegenerative diseases - e.g. ALS (Amyotrophic Lateral Sclerosis - Maladie de Charcot) • stimulation of the immune response e.g. for adoptive cell therapy of certain cancers • enhancement of safety of the use of embryonic stem cell-derived cultures for potential therapeutic benefit.
|1996||12(4):855-62||Nerve growth factor-induced accumulation of PC12 cells expressing cyclin D1: evidence for a G1 phase block||van Grunsven LA, Thomas A, Urdiales JL, Machenaud S, Choler P, Durand I, Rudkin BB||Oncogene||-|
|1989||Raven Press, Ltd., New York. 195-202||Nerve growth factor-sensitive phosphorylations and the action of K-252a on PC12 cells||Koizumi S, Mutoh T, Ryazanov A, Rudkin BB, Guroff G||Trophic Factors and the Nervous System||-|
|1997||15(4):393-402||Oncogenic activation of RET by two distinct FMTC mutations affecting the tyrosine kinase domain||Pasini A, Geneste O, Legrand P, Schlumberger M, Rossel M, Fournier L, Rudkin BB, Schuffenecker I, Lenoir GM, Billaud M||Oncogene||-|
|1993||54(3):161-75||Patterns of nerve growth factor (NGF), proNGF, and p75 NGF receptor expression in the rat incisor: comparison with expression in the molar||Mitsiadis TA, Couble P, Dicou E, Rudkin BB, Magloire H||Differentiation||-|
|2009||535:373-88||Peptide aptamers for small molecule drug discovery||Bardou C, Borie C, Bickle M, Rudkin BB, Colas P||Methods Mol Biol||-|
|1999||262(1):157-62||Phosphorylation by p44 MAP Kinase/ERK1 stimulates CBP histone acetyl transferase activity in vitro||Ait-Si-Ali S, Carlisi D, Ramirez S, Upegui-Gonzalez LC, Duquet A, Robin P, Rudkin BB, Harel-Bellan A, Trouche D||Biochem Biophys Res Commun||-|
|1999||73(10):8762-70||Possible interactions between the NS-1 protein and tumor necrosis factor alpha pathways in erythroid cell apoptosis induced by human parvovirus B19||Sol N, Le Junter J, Vassias I, Freyssinier JM, Thomas A, Prigent AF, Rudkin BB, Fichelson S, Morinet F||J Virol||-|
|1999||pp254 - 255. Directorate General Research ed.||Proliferation, Differentiation, Apoptosis : What's the difference?||Rudkin BB||Biomedical and health research programme 1994-1998, Summaries of projects supported under Biomed2, Volume 1||-|
|1991||285(2):170-5||Regulation of protein synthesis at the elongation stage. New insights into the control of gene expression in eukaryotes||Ryazanov AG, Rudkin BB, Spirin AS||FEBS Lett||-|
|1999||10(7):1129-38||Retroviral vectors for the expression of two genes in human multipotent neural precursors and their differentiated neuronal and glial progeny||Derrington EA, López-Lastra M, Chapel-Fernandez S, Cosset FL, Belin MF, Rudkin BB, Darlix JL||Hum Gene Ther||-|