Research Director at the CNRS within the Stem Cell and Brain Research Institute (SBRI), Inserm U1208, University of Lyon and Co-Founder, in 2009, of the Joint Laboratory on Neuropathogenesis along with Prof. Chonggang YUAN at East China Normal University (ECNU) in Shanghai, integrated into the Key Laboratory of Brain Functional Genomics at the ECNU in January 2014.
The main objective is the transfer of fundamental discoveries using small antibody mimetics called peptide aptamers, to potential patient benefit in the context of the StemGamE platform.
The present transfer focus: • neurodegenerative diseases - e.g. ALS (Amyotrophic Lateral Sclerosis - Maladie de Charcot) • stimulation of the immune response e.g. for adoptive cell therapy of certain cancers • enhancement of safety of the use of embryonic stem cell-derived cultures for potential therapeutic benefit.
|1996||12(2):309-22||Withdrawal of differentiation inhibitory activity/leukemia inhibitory factor up-regulates D-type cyclins and cyclin-dependent kinase inhibitors in mouse embryonic stem cells||Savatier P, Lapillonne H, van Grunsven LA, Rudkin BB, Samarut J||Oncogene|
|1996||12(2):309-22||Withdrawal of differentiation inhibitory activity/leukemia inhibitory factor up-regulates D-type cyclins and cyclin-dependent kinase inhibitors in mouse embryonic stem cells||Savatier P, Lapillonne H, van Grunsven LA, Rudkin BB, Samarut J||Oncogene||-|
|2003||278(10):8706-16||Trafficking of TrkA-green fluorescent protein chimerae during nerve growth factor-induced differentiation||Jullien J, Guili V, Derrington EA, Darlix JL, Reichardt LF, Rudkin BB||J Biol Chem||-|
|1991||3:1-5||To divide or not to divide: When, where and how. Molecular control of the cell cycle and cell differentiation||Rudkin BB||The New Biol||-|
|1996||13(10):2047-54||The CDK inhibitor p21WAF1/Cip1 is induced through a p300-dependent mechanism during NGF-mediated neuronal differentiation of PC12 cells||Billon N, van Grunsven LA, Rudkin BB||Oncogene||-|
|1998||16(7):825-32||Specific TrkA survival signals interfere with different apoptotic pathways||Ulrich E, Duwel A, Kauffmann-Zeh A, Gilbert C, Lyon D, Rudkin BB, Evan G, Martin-Zanca D||Oncogene||-|
|2000||90:113-125||Sensory neurons respond to long-lasting inflammatory pain by directing NGF receptors to their central terminals and enhancing their projection field in deep layers of the dorsal horn||Pezet S, Onténiente, B, Jullien, J, Junier MP, Grannec G, Rudkin BB, Calvino B||Pain||-|
|1999||10(7):1129-38||Retroviral vectors for the expression of two genes in human multipotent neural precursors and their differentiated neuronal and glial progeny||Derrington EA, López-Lastra M, Chapel-Fernandez S, Cosset FL, Belin MF, Rudkin BB, Darlix JL||Hum Gene Ther||-|
|1991||285(2):170-5||Regulation of protein synthesis at the elongation stage. New insights into the control of gene expression in eukaryotes||Ryazanov AG, Rudkin BB, Spirin AS||FEBS Lett||-|
|1999||pp254 - 255. Directorate General Research ed.||Proliferation, Differentiation, Apoptosis : What's the difference?||Rudkin BB||Biomedical and health research programme 1994-1998, Summaries of projects supported under Biomed2, Volume 1||-|