Since 20 years, my research focuses on the neurobiology of mood disorders and their responses to antidepressant treatments. A main goal is to understand the neural bases associated to the antidepressant responses in order to develop novel therapeutics for affective disorders. My work particularly focus on gaining a clearer understanding of the physiology and pharmacology of brain monoamine neurotransmitters and how these neurotransmitter systems are affected by established and novel antidepressant strategies. To this end, I utilize a wide range of techniques including in vivo electrophysiology, behavioural analysis and immunocytochemistry.
|2018||24(12):1129-1139||The novel atypical antipsychotic cariprazine demonstrates dopamine D2 receptor-dependent partial agonist actions on rat mesencephalic dopamine neuronal activity||Delcourte S, Ashby CR Jr, Rovera R, Kiss B, Adham N, Farkas B, Haddjeri N||CNS Neurosci Ther||-|
|2019||17(3):e2006211||Rods contribute to the light-induced phase shift of the retinal clock in mammals||Calligaro H, Coutanson C, Najjar RP, Mazzaro N, Cooper HM, Haddjeri N, Felder-Schmittbuhl MP, Dkhissi-Benyahya O||PLoS Biol||-|
|2019||6(3):ENEURO.0021-19.2019. doi: 10.1523/ENEURO.0021-19.2019||Serotonin Neuronal Function from the Bed to the Bench: Is This Really a Mirrored Way?||Adeline Etievant, Thorsten Lau, Guillaume Lucas, Nasser Haddjeri||eNeuro||-|
|2020||229(1):e13440. doi: 10.1111/apha.13440||Genetic and pharmacological inactivation of astroglial connexin 43 differentially influences the acute response of antidepressant and anxiolytic drugs||Benjamin Portal, Sarah Delcourte, Renaud Rovera, Camille Lejards, Sebastien Bullich, Cécile E Malnou, Nasser Haddjeri, Nicole Déglon, Bruno P Guiard||Acta Physiol (Oxf)||-|
|2020||pp 1-19||Antidepressants: Molecular Aspects of SSRIs||Etievant A, Haddjeri N, Lau T||NeuroPsychopharmacotherapy||-|
|2021||https://doi.org/10.1016/bs.pbr.2021.01.002||Role of central serotonin and noradrenaline interactions in the antidepressants’ action: Electrophysiological and neurochemical evidence||Delcourte S, Etievant A, Haddjeri N||Progress in Brain Research||-|
|2021||22(2):E937||Learned Immobility Produces Enduring Impairment of the HPA Axis Reactivity in Mice without Replicating the Broad Spectrum of Depressive-Like Phenotype||Sébastien Bullich, Sarah Delcourte, Nasser Haddjeri, Bruno P Guiard||Int J Mol Sci||-|