Since 20 years, my research focuses on the neurobiology of mood disorders and their responses to antidepressant treatments. A main goal is to understand the neural bases associated to the antidepressant responses in order to develop novel therapeutics for affective disorders. My work particularly focus on gaining a clearer understanding of the physiology and pharmacology of brain monoamine neurotransmitters and how these neurotransmitter systems are affected by established and novel antidepressant strategies. To this end, I utilize a wide range of techniques including in vivo electrophysiology, behavioural analysis and immunocytochemistry.
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Reference | Title | Authors | Journal | PUB MED | ||
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2018 | 24(12):1129-1139 | The novel atypical antipsychotic cariprazine demonstrates dopamine D2 receptor-dependent partial agonist actions on rat mesencephalic dopamine neuronal activity | Delcourte S, Ashby CR Jr, Rovera R, Kiss B, Adham N, Farkas B, Haddjeri N | CNS Neurosci Ther | - | ||
2019 | 17(3):e2006211 | Rods contribute to the light-induced phase shift of the retinal clock in mammals | Calligaro H, Coutanson C, Najjar RP, Mazzaro N, Cooper HM, Haddjeri N, Felder-Schmittbuhl MP, Dkhissi-Benyahya O | PLoS Biol | - | ||
2019 | 6(3):ENEURO.0021-19.2019. doi: 10.1523/ENEURO.0021-19.2019 | Serotonin Neuronal Function from the Bed to the Bench: Is This Really a Mirrored Way? | Adeline Etievant, Thorsten Lau, Guillaume Lucas, Nasser Haddjeri | eNeuro | - | ||
2020 | 229(1):e13440. doi: 10.1111/apha.13440 | Genetic and pharmacological inactivation of astroglial connexin 43 differentially influences the acute response of antidepressant and anxiolytic drugs | Benjamin Portal, Sarah Delcourte, Renaud Rovera, Camille Lejards, Sebastien Bullich, Cécile E Malnou, Nasser Haddjeri, Nicole Déglon, Bruno P Guiard | Acta Physiol (Oxf) | - | ||
2020 | pp 1-19 | Antidepressants: Molecular Aspects of SSRIs | Etievant A, Haddjeri N, Lau T | NeuroPsychopharmacotherapy | - | ||
2021 | https://doi.org/10.1016/bs.pbr.2021.01.002 | Role of central serotonin and noradrenaline interactions in the antidepressants’ action: Electrophysiological and neurochemical evidence | Delcourte S, Etievant A, Haddjeri N | Progress in Brain Research | - | ||
2021 | 22(2):E937 | Learned Immobility Produces Enduring Impairment of the HPA Axis Reactivity in Mice without Replicating the Broad Spectrum of Depressive-Like Phenotype | Sébastien Bullich, Sarah Delcourte, Nasser Haddjeri, Bruno P Guiard | Int J Mol Sci | - | ||