Since 20 years, my research focuses on the neurobiology of mood disorders and their responses to antidepressant treatments. A main goal is to understand the neural bases associated to the antidepressant responses in order to develop novel therapeutics for affective disorders. My work particularly focus on gaining a clearer understanding of the physiology and pharmacology of brain monoamine neurotransmitters and how these neurotransmitter systems are affected by established and novel antidepressant strategies. To this end, I utilize a wide range of techniques including in vivo electrophysiology, behavioural analysis and immunocytochemistry.
|2006||26(20):5370-82||GABAergic network activation of glial cells underlies hippocampal heterosynaptic depression||Serrano A, Haddjeri N, Lacaille JC, Robitaille R||J Neurosci||-|
|2005||30(7):1269-77||Effects of acute and long-term administration of escitalopram and citalopram on serotonin neurotransmission: an in vivo electrophysiological study in rat brain||El Mansari M, Sánchez C, Chouvet G, Renaud B, Haddjeri N||Neuropsychopharmacology||-|
|2004||29(10):1800-6||Electrophysiological evidence for the tonic activation of 5-HT(1A) autoreceptors in the rat dorsal raphe nucleus||Haddjeri N, Lavoie N, Blier P||Neuropsychopharmacology||-|
|2001||50(3):191-9||Sustained blockade of neurokinin-1 receptors enhances serotonin neurotransmission||Haddjeri N, Blier P||Biol Psychiatry||-|
|2000||22(4):346-56||Increased tonic activation of rat forebrain 5-HT(1A) receptors by lithium addition to antidepressant treatments||Haddjeri N, Szabo ST, de Montigny C, Blier P||Neuropsychopharmacology||-|
|1999||45(9):1163-9||Modulation of the firing activity of rat serotonin and noradrenaline neurons by (+/-)pindolol||Haddjeri N, de Montigny C, Blier P||Biol Psychiatry||-|
|1998||18(23):10150-6||Long-term antidepressant treatments result in a tonic activation of forebrain 5-HT1A receptors||Haddjeri N, Blier P, de Montigny C||J Neurosci||-|