Since 20 years, my research focuses on the neurobiology of mood disorders and their responses to antidepressant treatments. A main goal is to understand the neural bases associated to the antidepressant responses in order to develop novel therapeutics for affective disorders. My work particularly focus on gaining a clearer understanding of the physiology and pharmacology of brain monoamine neurotransmitters and how these neurotransmitter systems are affected by established and novel antidepressant strategies. To this end, I utilize a wide range of techniques including in vivo electrophysiology, behavioural analysis and immunocytochemistry.
Year | Reference |
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Authors | Journal | PUB MED | ||
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2006 | 26(20):5370-82 | GABAergic network activation of glial cells underlies hippocampal heterosynaptic depression | Serrano A, Haddjeri N, Lacaille JC, Robitaille R | J Neurosci | - | ||
2020 | 229(1):e13440. doi: 10.1111/apha.13440 | Genetic and pharmacological inactivation of astroglial connexin 43 differentially influences the acute response of antidepressant and anxiolytic drugs | Benjamin Portal, Sarah Delcourte, Renaud Rovera, Camille Lejards, Sebastien Bullich, Cécile E Malnou, Nasser Haddjeri, Nicole Déglon, Bruno P Guiard | Acta Physiol (Oxf) | - | ||
2000 | 22(4):346-56 | Increased tonic activation of rat forebrain 5-HT(1A) receptors by lithium addition to antidepressant treatments | Haddjeri N, Szabo ST, de Montigny C, Blier P | Neuropsychopharmacology | - | ||
2018 | 23(3):587-596 | Inducing a long-term potentiation in the dentate gyrus is sufficient to produce rapid antidepressant-like effects | Kanzari A, Bourcier-Lucas C, Freyssin A, Abrous DN, Haddjeri N, Lucas G | Mol Psychiatry | - | ||
2015 | 89:382-90 | Involvement of 5-HT₇ receptors in vortioxetine's modulation of circadian rhythms and episodic memory in rodents | Westrich L, Haddjeri N, Dkhissi-Benyahya O, Sánchez C | Neuropharmacology | - | ||
1998 | 18(23):10150-6 | Long-term antidepressant treatments result in a tonic activation of forebrain 5-HT1A receptors | Haddjeri N, Blier P, de Montigny C | J Neurosci | - | ||
1999 | 45(9):1163-9 | Modulation of the firing activity of rat serotonin and noradrenaline neurons by (+/-)pindolol | Haddjeri N, de Montigny C, Blier P | Biol Psychiatry | - | ||
2011 | 36(6):1275-88 | Pharmacological blockade of 5-HT7 receptors as a putative fast acting antidepressant strategy | Mnie-Filali O, Faure C, Lambás-Señas L, El Mansari M, Belblidia H, Gondard E, Etiévant A, Scarna H, Didier A, Berod A, Blier P, Haddjeri N | Neuropsychopharmacology | - | ||
2014 | 18(2) | Protein kinase C inhibition rescues manic-like behaviors and hippocampal cell proliferation deficits in the sleep deprivation model of mania | Abrial E, Bétourné A, Etiévant A, Lucas G, Scarna H, Lambás-Señas L, Haddjeri N | Int J Neuropsychopharmacol | - | ||
2013 | 43:40-8 | Protein kinase C regulates mood-related behaviors and adult hippocampal cell proliferation in rats | Abrial E, Etievant A, Bétry C, Scarna H, Lucas G, Haddjeri N, Lambás-Señas L | Prog Neuropsychopharmacol Biol Psychiatry | - | ||