Alumni Team : "Chronobiology and affective disorders"
The research aims of Neurobiological Rhythms and Sleep are focused on the molecular, cellular and behavioral mechanisms of the circadian timing system and the consequences of aging and neurodegenerative disease. Our approaches strive to understand the mechanisms of synchronization of circadian rhythms by lignt, the molecular and physiological mechanisms of the endogenous circadian oscillators, and the regulation of output behavioral and physiological rhythms. The coding of photic information by retinal photoreceptors (rods, cones, melanopsin ganglion cells) are studied using in vivo electrophysiological recording techniques in anaesthetised and awake, freely moving animals. The effects of light (intensity, duration, spectrum) on SCN neuronal activity and on clock gene expression are also assayed using quantitative RT-PCR and microarray analysis. In order to understand the consequences of chronobiological disorders, another line of research involves investigation of the mechanisms of synchronisation of central and peripheral oscillators, including the expression of clock genes and rhythmically expressed clock controlled genes in the brain and in different body tissues. Pathological models studied include ocular diseases and Parkinson's disease in rodents and aging in a prosimian primate. In humans, circadian photoreception and entrainment of the circadian timing system as well as chronobiological disorders related to ocular pathologies, aging and neurodegenerative diseases are studied in the framework of a European integrated project EUClock in our clinically based Platform for Research on Human Chronobiology. In order to bridge the gap between cellular-molecular studies in rodent models and clinical studies in humans, the non-human primate is used to study the circadian timing system and sleep wake cycle and, in the framework of the laboratory transverse project, the chronobiological consequences of Parkinson's Disease.
|2006||142(2):325-327.e1||Melatonin concentrations in aqueous humor of glaucoma patients||Chiquet C, Claustrat B, Thuret G, Brun J, Cooper HM, Denis P||Am J Ophthalmol|
|1999||117(6):848||Is the study of blind patients useful for understanding light perception?||Chiquet C, Dkhissi-Benyahya O, Cooper HM||Arch Ophthalmol||-|
|1998||96(1-2):173-83||Rest-activity rhythm of the blind mole rat Spalax ehrenbergi under different lighting conditions||Tobler I, Herrmann M, Cooper HM, Negroni J, Nevo E, Achermann P||Behav Brain Res|
|1996||48(3):121-9||Unusual pattern of retinogeniculate projections in the controversial primate Tarsius||Rosa MG, Pettigrew JD, Cooper HM||Brain Behav Evol||-|
|1989||477(1-2):350-7||Retinal projection to mammalian telencephalon||Cooper HM, Mick G, Magnin M||Brain Res||-|
|2003||965(1-2):1-8||Increased masking response to light after ablation of the visual cortex in mice||Redlin U, Cooper HM, Mrosovsky N||Brain Res|
|2003||967(1-2):48-62||Organization of the circadian system in the subterranean mole rat, Cryptomys hottentotus (Bathyergidae)||Negroni J, Bennett NC, Cooper HM||Brain Res|
|1989||488(1-2):390-7||Retinohypothalamic pathway: a breach in the law of Newton-Müller-Gudden?||Magnin M, Cooper HM, Mick G||Brain Res||-|
|1998||805(1-2):213-9||Is there a geniculohypothalamic tract in primates? A comparative immunohistochemical study in the circadian system of strepsirhine and haplorhine species||Chevassus-au-Louis N, Cooper HM||Brain Res|
|1994||654(1):81-4||Photic induction of Fos immunoreactivity in the suprachiasmatic nuclei of the blind mole rat (Spalax ehrenbergi)||Vuillez P, Herbin M, Cooper HM, Nevo E, Pévet P||Brain Res||-|