Alumni Team "Cellular reprogramming in the brain"
I am interested in exploring pathological conditions in the brain and novel avenues for brain repair. My master’s thesis was focused on identifying putative targets of the endocannabinoid system and their impact on cell death using in vitro models of disease.
The goal of my project is 1) to convert glia cells into so-called induced neurons, that acquire phenotypic properties analogous to their endogenous counterparts; and 2) to identify critical molecular events during this reprogramming process.
|2021||28(12):2104-2121||Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of mesial temporal lobe epilepsy||Célia Lentini, Marie d'Orange, Nicolás Marichal, Marie-Madeleine Trottmann, Rory Vignoles, Louis Foucault, Charlotte Verrier, Céline Massera, Olivier Raineteau, Karl-Klaus Conzelmann, Sylvie Rival-Gervier, Antoine Depaulis, Benedikt Berninger, Christophe Heinrich||Cell Stem Cell||-|
|2019||S1471-4914(19)30168-6||Direct Lineage Reprogramming for Brain Repair: Breakthroughs and Challenges||Vignoles R, Lentini C, d'Orange M, Heinrich C||Trends Mol Med||-|