Rudkin Brian B.
Brian B. Rudkin / DR2 - CNRS
Research interests
Research Director at the CNRS within the Stem Cell and Brain Research Institute (SBRI), Inserm U1208, University of Lyon and Co-Founder, in 2009, of the Joint Laboratory on Neuropathogenesis along with Prof. Chonggang YUAN at East China Normal University (ECNU) in Shanghai, integrated into the Key Laboratory of Brain Functional Genomics at the ECNU in January 2014.
The main objective is the transfer of fundamental discoveries using small antibody mimetics called peptide aptamers, to potential patient benefit in the context of the StemGamE platform.
The present transfer focus: • neurodegenerative diseases - e.g. ALS (Amyotrophic Lateral Sclerosis - Maladie de Charcot) • stimulation of the immune response e.g. for adoptive cell therapy of certain cancers • enhancement of safety of the use of embryonic stem cell-derived cultures for potential therapeutic benefit.
Member of Platforms
Selected Publications of Brian B. Rudkin
Year |
Reference | Title | Authors | Journal | PUB MED | ||
|---|---|---|---|---|---|---|---|
| 2017 | 18(4): 693 | Nerve Growth Factor Signaling from Membrane Microdomains to the Nucleus: Differential Regulation by Caveolins | Spencer A, Yu L, Guilli V, Reynaud F, Ding YD, Jullien J, Koubi D, Gauthier E, Cluet D, Rudkin BB, Falk J, Castellani V, Yuan CG | Int J Mol Sci | - | ||
| 2015 | 2;8:2 | Highly efficient method for gene delivery into mouse dorsal root ganglia neurons. | Yu L, Reynaud F, Falk J, Spencer A, Ding YD, Baumlé V, Lu R, Castellani V, Yuan C, Rudkin BB | Front Mol Neurosci | - | ||
| 2014 | 15 Suppl 14:S5 | EXACT2: the semantics of biomedical protocols | Soldatova LN, Nadis D, King RD, Basu PS, Haddi E, Baumlé V, Saunders NJ, Marwan W, Rudkin BB | BMC Bioinformatics | - | ||
| 2013 | 12(7):1939-52 | Calcineurin A versus NS5A-TP2/HD domain containing 2: a case study of site-directed low-frequency random mutagenesis for dissecting target specificity of peptide aptamers | Dibenedetto S, Cluet D, Stebe PN, Baumle V, Léault J, Terreux R, Bickle M, Chassey BD, Mikaelian I, Colas P, Spichty M, Zoli M, Rudkin BB | Mol Cell Proteomics | - | ||
| 2012 | 7(7):485-91 | Dorsal root ganglion progenitors differentiate to gamma-aminobutyric acid- and choline acetyltransferase-positive neurons | Yu L, Ding Y, Spencer A, Ma J, Lu R, Rudkin BB, Yuan C | Neural Regen Res | - | ||
| 2011 | 33:983-987 | Effect of Caveolin-1 on Proliferation and Survival of MCF-7 Breast | Lu R, Ma J, Zhang Y, Lu L, Spencer A, Cluet D, Rudkin BB, Yuan CG | Chin J Cell Biol | - | ||
| 2009 | 535:373-88 | Peptide aptamers for small molecule drug discovery | Bardou C, Borie C, Bickle M, Rudkin BB, Colas P | Methods Mol Biol | - | ||
| 2007 | 18(12):4899-910 | CD44 and beta3 integrin organize two functionally distinct actin-based domains in osteoclasts | Chabadel A, Bañon-Rodríguez I, Cluet D, Rudkin BB, Wehrle-Haller B, Genot E, Jurdic P, Anton IM, Saltel F | Mol Biol Cell | - | ||
| 2007 | 6(12):2110-21 | A comparative analysis of perturbations caused by a gene knock-out, a dominant negative allele, and a set of peptide aptamers | Abed N, Bickle M, Mari B, Schapira M, Sanjuan-España R, Robbe Sermesant K, Moncorgé O, Mouradian-Garcia S, Barbry P, Rudkin BB, Fauvarque MO, Michaud-Soret I, Colas P | Mol Cell Proteomics | - | ||
| 2007 | 6(11):1842-54 | Nerve growth factor receptor TrkA signaling in breast cancer cells involves Ku70 to prevent apoptosis | Com E, Lagadec C, Page A, El Yazidi-Belkoura I, Slomianny C, Spencer A, Hammache D, Rudkin BB, Hondermarck H | Mol Cell Proteomics | - | ||