The cerebral cortex is constituted by different type of neuronal cells working together to sustain most of our cognitive abilities. One critical step that ensures this higher function is the birth of the proper type and number of neurons during development. My project will contribute to this issue by examining the mode of cell division in the mouse Neocortex during development with a special emphasis on the Wnt/planar cell polarity pathway and its function in promoting a novel division mechanism discovered during my post-doctoral studies.
|2017||42:75-83||Division modes and physical asymmetry in cerebral cortex progenitors||Delaunay D, Kawaguchi A, Dehay C, Matsuzaki F||Curr Opin Neurobiol||-|
|2015||09:33||Mitotic spindle asymmetry in rodents and primates: 2D vs. 3D measurement methodologies||Delaunay D, Robini MC, Dehay C||Front Cell Neurosci||-|
|2014||6(2):400-14||Mitotic spindle asymmetry: a Wnt/PCP-regulated mechanism generating asymmetrical division in cortical precursors||Delaunay D, Cortay V, Patti D, Knoblauch K, Dehay C||Cell Rep||-|