Emmanuel Procyk Team Leader / DR2
We seek to understand how neural networks in the brain produce complex cognition. Specifically we take established knowledge about simple systems in the brain and understand how it can be applied to higher cognitive functions, often referred to as executive functions. These are functions that allow flexible behaviours that can be readily adapted in volatile environments. So for example neural firing rate, neural synchronization and oscillations are mechanisms by which the brain stores, transmits, and manipulates distributed information in simple perceptual functions. But how these mechanisms apply to higher cognitive functions it little understood.
We know that executive functions require appropriate interactions between large-scale neural networks, as well as modulation by monoaminergic systems. Our research targets the mechanisms of these processes, in particular in primate species. Executive functions, and their neural bases, have unique characteristics in primate species, and in humans in particular.
Our current projects aim at exploring how cognitive processes are specified by neural activity and dynamical interactions between frontal cortical areas, how neuromodulation contributes, and how network interactions change during adaptive behaviours. The frontal cortex has particularly evolved across mammals and in primates in particular. Our research also seeks to identify anatomical and functional principles of the frontal cortex that are conserved or that differ between primate species. Finally, we study the neural basis of the acquisition of these executive processes. We want to understand how the way in which executive functions are learned and acquired in the brain influences later cognition, with implications in a number of fields.
To address these questions we use multiple techniques (anatomy of connectivity, multiple-microelectrodes, ECoG, EEG, fMRI) to describe the anatomy and function of networks involved in higher cognitive functions in primates. We therefore employ a multi-level and comparative approach to studying cognitive processes. We build upon methods and techniques established at SBRI, as well as developing new theoretical, anatomical and technological approaches in collaboration with colleagues all over the world.
|2016||26(2):467-76||Midcingulate Motor Map and Feedback Detection: Converging Data from Humans and Monkeys||Procyk E, Wilson CR, Stoll FM, Faraut MC, Petrides M, Amiez C||Cereb Cortex|
|2018||355:76-89||Adaptive coordination of working-memory and reinforcement learning in non-human primates performing a trial-and-error problem solving task||Viejo G, Girard B, Procyk E, Khamassi M||Behav Brain Res||-|
|2018||38(36):7800-7808||The Rhesus Monkey Hippocampus Critically Contributes to Scene Memory Retrieval, But Not New Learning||Froudist-Walsh S, Browning PGF, Croxson PL, Murphy KL, Shamy JL, Veuthey TL, Wilson CRE, Baxter MG||J Neurosci|
|2018||100(1):61-74.e2||An Open Resource for Non-human Primate Imaging||Milham MP, Ai L, Koo B, Xu T, Amiez C, Balezeau F, Baxter MG, Blezer ELA, Brochier T, Chen A, Croxson PL, Damatac CG, Dehaene S, Everling S, Fair DA, Fleysher L, Freiwald W, Froudist-Walsh S, Griffiths TD, Guedj C, Hadj-Bouziane F, Ben Hamed S, Harel N, Hiba B, Jarraya B, Jung B, Kastner S, Klink PC, Kwok SC, Laland KN, Leopold DA, Lindenfors P, Mars RB, Menon RS, Messinger A, Meunier M, Mok K, Morrison JH, Nacef J, Nagy J, Rios MO, Petkov CI, Pinsk M, Poirier C, Procyk E, Rajimehr R, Reader SM, Roelfsema PR, Rudko DA, Rushworth MFS, Russ BE, Sallet J, Schmid MC, Schwiedrzik CM, Seidlitz J, Sein J, Shmuel A, Sullivan EL, Ungerleider L, Thiele A, Todorov OS, Tsao D, Wang Z, Wilson CRE, Yacoub E, Ye FQ, Zarco W, Zhou YD, Margulies DS, Schroeder CE||Neuron.|
|2018||8(1):13988||Variations of cingulate sulcal organization and link with cognitive performance||Amiez C, Wilson CRE, Procyk E||Sci Rep|
|2018||11:753||Rostro-Caudal Organization of Connectivity between Cingulate Motor Areas and Lateral Frontal Regions||Loh KK, Hadj-Bouziane F, Petrides M, Procyk E, Amiez C||Front Neurosci||-|
|2018||305:67-81||A novel approach to probabilistic characterisation of neural firing patterns||Mijatović G, Lončar-Turukalo T, Procyk E, Bajić D||J Neurosci Methods||-|
|2018||119(3):1037-1044||Reward activations and face fields in monkey cingulate motor areas||Cléry J, Amiez C, Guipponi O, Wardak C, Procyk E, Ben Hamed S||J Neurophysiol||-|
|2019||3437||Sulcal organization in the medial frontal cortex provides insights into primate brain evolution||Amiez C, Sallet J, Hopkins WD, Meguerditchian A, Hadj-Bouziane F, Ben Hamed S, Wilson CRE, Procyk E, Petrides M||Nat Commun||-|