Ouria Dkhissi-Benyahya Team Leader / CRCN
SBRI Team : 7_Chronobiology and affective disorders
SBRI Team
Chronobiology and Affective Disorders
Major depression is the leading cause of disability worldwide and current treatments are limited in terms of efficacy, delay of action and undesirable side effects. Light plays a critical role, directly and through the circadian system on clock function, sleep regulation, and cognitive and emotional brain responses. Chronobiological mechanisms are considered to play a significant role in affective disorders and recent data point recent advances have confirmed the use of light exposure strategies in novel treatments for affective disorders. Our team is dedicated to study the control mechanisms of chronobiological rhythms and fast and effective antidepressant responses. Our strategy has two main axes:
- Non-visual responses to light: mechanisms and applications. Our objective is to understand the basic mechanisms of non-visual photoreception and the effects of light on circadian rhythms, physiology and gene regulation in normal and pathological states. our studies address the cellular and molecular mechanisms underscoring circadian regulation, via an in-depth analysis of the photoreceptive pathways and genetic signalling of the retinal network.
- Early-onset antidepressant strategies: neurobiological mechanisms. In vivo evaluation of the impact of fast acting antidepressants on mood and cognition as well as on cerebral networks and plasticity will provide a better understanding of the neurobiological mechanisms underlying the antidepressant responsiveness in refractory major depression. In addition, to further improve antidepressants effectiveness, we will determine the potentiating effects of light exposure on the antidepressant response.
The results arising from the basic research of our program should be translated to potential clinical applications and be of important interest for public health.
SBRI Team
Selected Publications
| Year | Reference | Title | Authors |
Journal |
PUB MED | ||
|---|---|---|---|---|---|---|---|
| 2020 | 229(1):e13440. doi: 10.1111/apha.13440 | Genetic and pharmacological inactivation of astroglial connexin 43 differentially influences the acute response of antidepressant and anxiolytic drugs | Benjamin Portal, Sarah Delcourte, Renaud Rovera, Camille Lejards, Sebastien Bullich, Cécile E Malnou, Nasser Haddjeri, Nicole Déglon, Bruno P Guiard | Acta Physiol (Oxf) | - | ||
| 2016 | 80(6):e43-e44 | Deep Brain Stimulation for Depression: Is It a Gray or White "Matter"? | Etiévant A, Lucas G, Haddjeri N | Biol Psychiatry | - | ||
| 2013 | 70(18):3435-47 | The absence of melanopsin alters retinal clock function and dopamine regulation by light | Dkhissi-Benyahya O, Coutanson C, Knoblauch K, Lahouaoui H, Leviel V, Rey C, Bennis M, Cooper HM | Cell Mol Life Sci | - | ||
| 2018 | 24(12):1129-1139 | The novel atypical antipsychotic cariprazine demonstrates dopamine D2 receptor-dependent partial agonist actions on rat mesencephalic dopamine neuronal activity | Delcourte S, Ashby CR Jr, Rovera R, Kiss B, Adham N, Farkas B, Haddjeri N | CNS Neurosci Ther | - | ||
| 2015 | 2(8):898-908 | Astroglial Control of the Antidepressant-Like Effects of Prefrontal Cortex Deep Brain Stimulation | Etiévant A, Oosterhof C, Bétry C, Abrial E, Novo-Perez M, Rovera R, Scarna H, Devader C, Mazella J, Wegener G, Sánchez C, Dkhissi-Benyahya O, Gronfier C, Coizet V, Beaulieu JM, Blier P, Lucas G, Haddjeri N | EBioMedicine | - | ||
| 2017 | 4(2) | Stress Models of Depression: A Question of Bad Timing | Delcourte S, Dkhissi-Benyahya O, Cooper H, Haddjeri N | eNeuro | - | ||
| 2019 | 6(3):ENEURO.0021-19.2019. doi: 10.1523/ENEURO.0021-19.2019 | Serotonin Neuronal Function from the Bed to the Bench: Is This Really a Mirrored Way? | Adeline Etievant, Thorsten Lau, Guillaume Lucas, Nasser Haddjeri | eNeuro | - | ||
| 2021 | 22(2):E937 | Learned Immobility Produces Enduring Impairment of the HPA Axis Reactivity in Mice without Replicating the Broad Spectrum of Depressive-Like Phenotype | Sébastien Bullich, Sarah Delcourte, Nasser Haddjeri, Bruno P Guiard | Int J Mol Sci | - | ||
| 2018 | 23(3):587-596 | Inducing a long-term potentiation in the dentate gyrus is sufficient to produce rapid antidepressant-like effects | Kanzari A, Bourcier-Lucas C, Freyssin A, Abrous DN, Haddjeri N, Lucas G | Mol Psychiatry | - | ||
| 2020 | 26:106-116 | A standardized method to assess the endogenous activity and the light-response of the retinal clock in mammals | H Calligaro, C Kinane, M Bennis, C Coutanson, O Dkhissi-Benyahya | Mol Vis | - | ||