Pierre Savatier Team Leader / DR1
SBRI Team : 2_Pluripotent stem cells in mammals
SBRI Team
We explore the mechanisms of self-renewal and pluripotency using embryonic stem cells from several mammalian sepcies. In particular, we explore ground state pluripotency in the rabbit and primate pre-implantation embryos.
Our goal is to create rabbit and macaque ES cells capable of colonizing the developing embryo, suitable for the generation of chimaeras.
Another aspect of our work focuses on the regulation of the cell cycle, which shows unusual characteristics in pluripotent stem cells.
SBRI Team
Selected Publications
| Year |
Reference |
Title | Authors | Journal | PUB MED | ||
|---|---|---|---|---|---|---|---|
| 2016 | 7(3):383-98 | A Panel of Embryonic Stem Cell Lines Reveals the Variety and Dynamic of Pluripotent States in Rabbits | Osteil P, Moulin A, Santamaria C, Joly T, Jouneau L, Aubry M, Tapponnier Y, Archilla C, Schmaltz-Panneau B, Lecardonnel J, Barasc H, Mouney Bonnet N, Genthon C, Roulet A, Donnadieu C, Acloque H, Gocza E, Duranthon V, Afanassieff M, Savatier P | Stem Cell Reports | - | ||