Pierre Savatier Team Leader / DR1
SBRI Team : 2- Pluripotent stem cells in mammals
SBRI Team
We explore the mechanisms of self-renewal and pluripotency using embryonic stem cells from several mammalian sepcies. In particular, we explore ground state pluripotency in the rabbit and primate pre-implantation embryos.
Our goal is to create rabbit and macaque ES cells capable of colonizing the developing embryo, suitable for the generation of chimaeras.
Another aspect of our work focuses on the regulation of the cell cycle, which shows unusual characteristics in pluripotent stem cells.
SBRI Team
Selected Publications
Year |
Reference | Title | Authors | Journal | PUB MED | ||
|---|---|---|---|---|---|---|---|
| 2019 | 18(20):2697-2712 | Regulation of Cyclin E by transcription factors of the naïve pluripotency network in mouse embryonic stem cells | Gonnot F, Langer D, Bourillot PY, Doerflinger N, Savatier P | Cell Cycle | - | ||
| 2018 | 34(11):944-953 | Fifty shades of pluripotency | Afanassieff M, Aksoy I, Beaujean N, Bourillot PY, Savatier P | Med Sci (Paris) | - | ||
| 2017 | 19:104-112 | Pluripotency of embryo-derived stem cells from rodents, lagomorphs, and primates: Slippery slope, terrace and cliff | Savatier P, Osteil P, Tam PP | Stem Cell Res | - | ||
| 2017 | 24:106-117 | Reprogramming of rabbit induced pluripotent stem cells toward epiblast and chimeric competency using Krüppel-like factors | Tapponnier Y, Afanassieff M, Aksoy I, Aubry M, Moulin A, Medjani L, Bouchereau W, Osteil P, Nurse-Francis J, Oikonomakos I, Joly T, Jouneau L, Archilla C, Schmaltz-Panneau B, Peynot N, Barasc H, Pinton A, Lecardonnel J, Gocza E, Beaujean N, Duranthon V, Savatier P | Stem Cell Res | - | ||
| 2016 | 7(3):383-98 | A Panel of Embryonic Stem Cell Lines Reveals the Variety and Dynamic of Pluripotent States in Rabbits | Osteil P, Moulin A, Santamaria C, Joly T, Jouneau L, Aubry M, Tapponnier Y, Archilla C, Schmaltz-Panneau B, Lecardonnel J, Barasc H, Mouney Bonnet N, Genthon C, Roulet A, Donnadieu C, Acloque H, Gocza E, Duranthon V, Afanassieff M, Savatier P | Stem Cell Reports | - | ||
| 2015 | 6:7095 | Reinforcement of STAT3 activity reprogrammes human embryonic stem cells to naive-like pluripotency | Chen H, Aksoy I, Gonnot F, Osteil P, Aubry M, Hamela C, Rognard C, Hochard A, Voisin S, Fontaine E, Mure M, Afanassieff M, Cleroux E, Guibert S, Chen J, Vallot C, Acloque H, Genthon C, Donnadieu C, De Vos J, Sanlaville D, Guérin JF, Weber M, Stanton LW, Rougeulle C, Pain B, Bourillot PY, Savatier P | Nat Commun | - | ||
| 2014 | 5:3719 | Klf4 and Klf5 differentially inhibit mesoderm and endoderm differentiation in embryonic stem cells | Aksoy I, Giudice V, Delahaye E, Wianny F, Aubry M, Mure M, Chen J, Jauch R, Bogu GK, Nolden T, Himmelbauer H, Xavier Doss M, Sachinidis A, Schulz H, Hummel O, Martinelli P, Hübner N, Stanton LW, Real FX, Bourillot PY, Savatier P | Nat Commun | - | ||
| 2013 | 10(1):118-31 | A short G1 phase is an intrinsic determinant of naïve embryonic stem cell pluripotency | Coronado D, Godet M, Bourillot PY, Tapponnier Y, Bernat A, Petit M, Afanassieff M, Markossian S, Malashicheva A, Iacone R, Anastassiadis K, Savatier P | Stem Cell Res | - | ||
| 2013 | 2(6):613-28 | Induced pluripotent stem cells derived from rabbits exhibit some characteristics of naïve pluripotency | Osteil P, Tapponnier Y, Markossian S, Godet M, Schmaltz-Panneau B, Jouneau L, Cabau C, Joly T, Blachère T, Gócza E, Bernat A, Yerle M, Acloque H, Hidot S, Bosze Z, Duranthon V, Savatier P, Afanassieff M | Biol Open | |||
| 2010 | 107(41):17663-7 | Transgenic rhesus monkeys produced by gene transfer into early-cleavage-stage embryos using a simian immunodeficiency virus-based vector | Niu Y, Yu Y, Bernat A, Yang S, He X, Guo X, Chen D, Chen Y, Ji S, Si W, Lv Y, Tan T, Wei Q, Wang H, Shi L, Guan J, Zhu X, Afanassieff M, Savatier P, Zhang K, Zhou Q, Ji W | Proc Natl Acad Sci U S A | - | ||