Pierre Savatier Team Leader / DR1
We explore the mechanisms of self-renewal and pluripotency using embryonic stem cells from several mammalian sepcies. In particular, we explore ground state pluripotency in the rabbit and primate pre-implantation embryos.
Our goal is to create rabbit and macaque ES cells capable of colonizing the developing embryo, suitable for the generation of chimaeras.
Another aspect of our work focuses on the regulation of the cell cycle, which shows unusual characteristics in pluripotent stem cells.
|2010||107(41):17663-7||Transgenic rhesus monkeys produced by gene transfer into early-cleavage-stage embryos using a simian immunodeficiency virus-based vector||Niu Y, Yu Y, Bernat A, Yang S, He X, Guo X, Chen D, Chen Y, Ji S, Si W, Lv Y, Tan T, Wei Q, Wang H, Shi L, Guan J, Zhu X, Afanassieff M, Savatier P, Zhang K, Zhou Q, Ji W||Proc Natl Acad Sci U S A||-|