SBRI Stem-cell and Brain Research Institute - France (Lyon)


1) Perrard MH, Saez JM, Dazord A. Effects of FSH on acidic nuclear protein synthesis in cultured pig Sertoli cells. FEBS Lett., 1984, 168, 49-53.

2) Perrard MH, Saez JM, Dazord A. FSH stimulation of cytosolic protein synthesis in cultured pig Sertoli cells. J Steroid Biochem. 1985, 22, 281-284.

3) Perrard MH. Mutagenicity and toxicity of chloroethylene oxide and chloroacetaldehyde. Experientia. 1985 41, 676-677.

4) Barbin A, Besson F, Perrard MH, Bereziat JC, Kaldor J, Michel G, Bartsch H. Induction of specific base-pair substitutions in E. coli trpA mutants by chloroethylene oxide, a carcinogenic vinyl chloride metabolite. Mutat. Res. 1985, 152, 147-156.

5) Perrard-Sapori MH, Saez JM, Dazord A. Hormonal regulation of proteins secreted by cultured pig Sertoli cells: characterization by two-dimensional polyacrylamide gel electrophoresis. Mol Cell Endocrinol. 1985, 43 ,189-197.

6) Saez JM, Tabone E, Perrard-Sapori MH, Rivarola MA. Paracrine role of Sertoli cells. Med Biol. 1986, 63, 225-236.

7) Perrard-Sapori MH, Chatelain P, Vallier P, Saez JM. In vitro interactions between Sertoli cells and steroidogenic cells. Biochem Biophys Res Commun. 1986, 134, 957-962.

8) Saez JM, Perrard-Sapori MH, Chatelain PG, Tabone E, Rivarola MA. Paracrine regulation of testicular function. J Steroid Biochem. 1987, 27, 317-329. Review.

9) Chatelain P, Perrard-Sapori MH, Jaillard C, Naville D, Ruitton A, Saez J. Somat Somatomedin-C/insulin-like growth factor 1: a differentiating factor of testicular function. Int J Rad Appl Instrum B. 1987, 14, 617-622.

10) Perrard-Sapori MH, Chatelain PC, Rogemond N, Saez JM. Modulation of Leydig cell functions by culture with Sertoli cells or with Sertoli cell-conditioned medium: effect of insulin, somatomedin-C and FSH. Mol Cell Endocrinol.1987, 50, 193-201.

11) Perrard-Sapori MH, Chatelain PG, Jaillard C, Saez JM. Characterization and regulation of somatomedin-C/insulin-like growth factor I (Sm-C/IGF-I) receptors on cultured pig Leydig cells. Effects of Sm-C/IGF-I on luteotropin receptors and steroidogenesis. Eur J Biochem. 1987, 165, 209-214.

12) Avallet O, Vigier M, Perrard-Sapori MH, Saez JM. Transforming growth factor beta inhibits Leydig cell functions. Biochem Biophys Res Commun. 1987, 146, 575-581.

13) Saez JM, Chatelain PG, Perrard-Sapori MH, Jaillard C, Naville D. Differentiating effects of somatomedin-C/insulin-like growth factor I and insulin on Leydig and Sertoli cell functions. Reprod Nutr Dev. 1988, 28, 989-1008. IF 0.549.

14) Chatelain P, Penhoat A, Perrard-Sapori MH, Jaillard C, Naville D, Saez J. Maturation of steroidogenic cells: a target for IGF-I. Acta Paediatr Scand Suppl. 1988, 347, 104-109.

15) Saez JM, Avallet O, Naville D, Perrard-Sapori MH, Chatelain PG. Sertoli-Leydig cell communications. Ann. NY Acad Sci, 1989, 564, 210-231. Review. IF : 1,405

16) Reventos J, Perrard-Sapori MH, Chatelain PG, Saez JM. Leydig cell and extracellular matrix effects on Sertoli cell function: biochemical and morphologic studies. J Androl. 1989, 10, 359-365. IF 1.424.

17) Weiss M, Vigier M, Hue D. Perrard-Sapori MH, Marret C, Avallet O & Durand P. Pre- and post-meiotic expression of male germ cell specific genes throughout 2-week cocultures of germinal and Sertoli cells. Biol Reprod, 1997, 57, 68-76. IF 3.036

18) Perrard-Sapori MH, Vigier M, Hue D, Staub C, Weiss M, Durand Ph. Spermatogenèse murine in vitro : étude cytologique de l'étape méiotique.Contracept Fertil Sex, 1997, 25, 556-564. IF 0.194.

19) Hue D, Staub C, Perrard-Sapori MH, Weiss M, Nicolle JC, Vigier M, Durand Ph. Meiotic differentiation of germinal cells in three week cultures of whole cell population from rat seminiferous tubules.Biol Reprod, 1998, 59, 379-387. IF 3.327.

20) Marret C, Avallet O, Perrard-Sapori MH, Durand Ph. Localization and quantitative expression of mRNAs encoding the testis specific histone TH2B, the phosphoprotein p19, the transition proteins 1 and 2 during pubertal development and throughout the spermatogenic cycle of the rat. Mol Reprod Develop, 1998, 51, 22-35. IF 2.399.

21) Staub C, Hue D, Nicolle JC, Perrard-Sapori MH, Segretain D, Durand P. The whole meiotic process can occur in vitro in untransformed rat spermatogenic cells. Exp Cell Res, 2000, 260, 85-95. IF 3.860.

22) Perrard MH, Hue D, Staub C, LeVern Y, Kerboeuf D, Durand Ph. Development of the meiotic step in testes of pubertal rats : comparison between the in vivo situation and under in vitro conditions. Mol Reprod Develop, 2003, 65, 86-95. IF 2.543

23) Vigier M, Weiss M, Perrard MH, Godet M, Durand Ph. The effects of FSH and testosterone on the completion of meiosis and the very early steps of spermiogenesis of the rat : an in vitro study. J Mol Endocrinol, 2004, 33, 729-742. IF 3.855

24) Damestoy A, Perrard MH, Vigier M, Sabido O, Durand Ph. Transforming growth β1 decreases the yield of the second meiotic division of rat pachytene spermatocytes in vitro. Reprod Biol Endocrinol. 2005, 3, 22-32. IF 2.370

25) Plotton I, Sanchez P, Perrard MH, Durand Ph, Lejeune H. Quantification of stem cell factor mRNA levels in rat testis: usefulness of clusterin mRNA levels as markers of the amount of mRNAs of Sertoli cell origin. J Endocrinol, 2005, 186, 131-143. IF 2.636

26) Perrard MH, Vigier M, Damestoy A, Chapat C, Silandre D, Rudkin BB, Durand P. Beta nerve growth factor participates in an auto/paracrine pathway of regulation of the meiotic differentiation of rat spermatocytes. J Cell Physiol, 2007, 210, 51-62. IF 3.643

27) Perrard MH, Durand P. Redundancy of the effect of TGFbeta1 and beta-NGF on the second meiotic division of rat spermatocytes. Microsc Res Tech, 2009, 72(8), 596-602. IF 2.320

28) Perrard MH, Chassaing E, Montillet G, Sabido O, Durand P. Cytostatic Factor Proteins Are Present in Male Meiotic Cells and β-Nerve Growth Factor Increases Mos Levels in Rat Late Spermatocytes. PloS One. 2009. Oct 5; 4(10):e7237.

29) Bouhallier F., Allioli N., Lavial F., Chalmel F, Perrard M-H., Durand P., Samarut J., Pain B., Rouault J-P. Role of miR-34c microRNA in the late steps of spermatogenesis. RNA. 2010 Apr;16(4):720-31. Epub 2010 Feb 11.

30) Perrard M-H, Grenet C, Prisant N, Geoffroy-Siraudin S, Segretain D, Guichaoua M, Pointis G, Durand P. De l’étude des mécanismes de régulation de la spermatogenèse à la reprotoxicologie par approche ex vivo : pour une meilleure application de REACH. Medecine/Sciences (Paris). 2010 Mar; 26(3):305-310. French.

31) Geoffroy-Siraudin C, Perrard M-H, Chaspoul F, Lanteaume A, Gallice P, Durand P, Guichaoua M-R. Validation of a rat seminiferous tubule culture model as a suitable system for studying toxicant impact on meiosis effect of hexavalent chromium. Toxicological Sciences. 2010 Jul ; 116(1) :286-296. IF 4.814

32) Geoffroy-Siraudin C, Loundou AD, Romain F, Achard V, Courbière B, Perrard M-H, Durand P, Guichaoua M-R. Evolution of semen quality among 10932 males consulting for couple infertility over a 20 years period in Marseilles, France. Asian Journal of Andrology. 2012 Apr 23. doi: 10.1038/aja.2011.173.

33) Perrard M-H, Geoffroy-Siraudin C, Ghalamoun-Slaimi R, Ali S, Chaspoul F, Lanteaume A, Achard V, Gallice P, Durand P, Guichaoua M-R. Ex-vivo assessment of the chronic toxicity of low levels of cadmium on testicular meiotic cells. Toxicol Appl Pharmacol. 2012 Aug 1;262(3):238-46.

34) Perrard M-H, Carette D, Prisant N, Gilleron J, Pointis G, Segretain D, Durand P. Hexavalent chromium at low concentration alters Sertoli cell barrier and connexin 43 gap junction but not claudin-11 and N-cadherin in the rat seminiferous tubule culture model. Toxicology and Applied Pharmacology 268 (2013) 27–36.

35) Le Borgne M, Chartier N, Buchet-Poyau K, Destaing O, Faurobert E, Thibert C, Rouault JP, Courchet J, Nègre D, Bouvard D, Albiges-Rizo C, Rousseaux S, Khochbin S, Segretain D, Crépieux P, Guillou F, Durand P, Perrard MH, Billaud M. The RNA-binding protein Mex3b regulates the spatial organization of the Rap1 pathway. Development 2014 May; 141(10):2096-107.

36) Sazan A, Steinmetz G, Montillet G, Perrard M-H, Loundou A, Durand P, Guichaoua M-R, Prat O. Exposure to Low-Dose Bisphenol A Impairs Meiosis in the Rat Seminiferous Tubule Culture Model: A Physiotoxicogenomic Approach. PLoS One. 2014 Sep 2;9(9):e106245.

37) Carette D, Blondet A, Martin G, Montillet G, Janczarski S, Christin E, PointisG, Durand P and Perrard M-H. Endocrine Disrupting Effects of Noncytotoxic Doses of Carbendazim on the Pubertal Rat Seminiferous Epithelium: An Ex Vivo Study. Applied in Vitro Toxicology. 2015 Volume 1, Number 4, 289-301.

38) Goldstein KM, Seyler DE, Durand P, Perrard M-H, Baker TK. Use of a Rat ex-vivo Testis Culture Method to Assess Toxicity of Select Known Male Reproductive Toxicants. Reproductive Toxicology. 2016, 60, 92–103.

39) Pisani C, Voisin S, Arafah K, Durand P, Perrard M-H, Guichaoua M-R, Bulet P and Prat O. Ex vivo assessment of testicular toxicity induced by carbendazim and iprodione, alone or in a mixture. ALTEX Online first published May 8, 2016

40) Perrard M-H, Sereni N, Schluth-Bolard C, Blondet A, Giscard d’Estaing S, Plotton I, Morel-Journel N, Lejeune H, David L and Durand Ph. Complete human and rat ex-vivo spermatogenesis from fresh or 1 frozen testicular tissue. Biology of Reproduction, 2016, 95 (4): 89, 1-10.  

41) Durand P, Martin G, Blondet A, Gilleron J, Carette D, Janczarski S, Christin E, Pointis G and Perrard M-H. Effects of low doses of carbendazim or iprodione either separately or in mixture on the pubertal rat seminiferous epithelium: An ex vivo study. Toxicol In Vitro. 2017 Dec;45(Pt 3):366-373.

42) Sereni N,  Enache A, Sudre G, Montembault A, Rochas C, Durand P, Perrard MH, Bozga G, Puaux JP, Delair T and David L. Dynamic structuration of physical chitosan hydrogels. Langmuir 2017 Nov 7;33(44):12697-12707.