SBRI Stem-cell and Brain Research Institute - France (Lyon)

PhD Thesis Defense by Stefan Sweifel

Date event : March 29, 2018 - 2:00pm Conference / Talk Published on 03/26/2018 - 9:57am

Exploring Transcriptional Heterogeneity in the Postnatal SVZ

Stefan Sweifel

29 March 2018, 14:00

SBRI conference room


Germinal activity persists in the postnatal mammalian brain in specialized niches, namely the dentate gyrus (DG) of the hippocampus and the subventricular zone (SVZ) surrounding the lateral ventricle (LV). Neural stem cells (NSCs) of the postnatal SVZ differentiate into transient amplifying progenitors (TAPs) that will generate neuroblasts migrating through the rostral migratory stream (RMS), into the olfactory bulb (OB), where they differentiate into neurons. The SVZ additionally generates glial progenitors that invade the nearby parenchyma. Recent work to which I have participated, highlights the heterogeneous nature of the postnatal SVZ in respect to different microdomains generating distinct neural lineages.


Jury Members:


-Rapporteure: Nathalie Spassky

-Rapporteur: Antoine De Chevigny

-Examinatrice: Bénédicte Durand

-Directeur de thèse: Olivier Raineteau