Date event : December 17, 2018 - 4:00pm Conference / Talk Published on 12/07/2018 - 3:42pm
Princeton Neuroscience Institute
The selection of information from cluttered sensory environments is one of the most fundamental cognitive operations performed by the primate brain. This process engages a large-scale network that consists of multiple nodes, distributed across cortical and subcortical regions. The lecture will focus on temporal dynamics within this network that shape both the sampling of and responses to our environment, with an emphasis on thalamo-cortical interactions. The lecture will also discuss the importance of comparative electrophysiology and neuroimaging in human and monkey brains.
Department of Physiology, Anatomy and Genetics; University of Oxford
The mammalian neocortex appeared through changes of the developmental programs of neurogenesis, neuronal migration and circuit assembly that diverged in mammalian, reptilian and avian brains. We are interested in the shared and distinct developmental processes and review recent comparative developmental and transcriptomic data to identify divergent features as key triggers neocortical evolution. We identified tangential migratory streams in the mammalian cortex that delivered novel populations of early generated glutamatergic neurons, but did not identify such tangentially migrating populations in the avian brain (1-3). We observed de novo generation of cortical neurons from fate restricted cortical progenitors that form the interhemispehric connections through the corpus callosum in mouse, but not in chick (4). We recognized secondary proliferative domains with novel progenitors with specific fate restrictions that increased neurogenesis (5-6). Modelling parameters and relative proportions of proliferative periods helped us to identify the key factors responsible for increase in mammalian brain size (7). Comparisons of transcriptomes from selected brain regions in various species revealed considerable divergence between cell populations with developmental homologies (8). As a consequence of the above changes, the mammalian dorsal pallium is unique; it is populated by diverse neuronal populations that are generated according to a strict temporal sequence, neurons are arranged into layers and radial modules that communicate between the two hemispheres.
(1) Pedraza et al., (2014) PNAS U S A. 111(23):8613-8.
(2) García-Moreno et al., (2018) Cell Rep. 22(1):96-109.
(3) Rueda-Alaña et al., (2018) Front Neurosci. 12:792.
(4) García-Moreno and Molnár (2015) PNAS U S A. 112(36):E5058-67.
(5) García-Moreno et al., (2012) Cereb Cortex. 22(2):482-92.
(6) Vasistha et al., (2015) Cereb Cortex. 25(10):3290-302.
(7) Picco et al., (2018) Cereb Cortex. 28(7):2540-2550.
(8) Belgard et al., (2013) PNAS U S A. 110(32):13150–13155.
(9) Lein et al., (2017) Annu Rev Neurosci. 40:629-652.