SBRI Stem-cell and Brain Research Institute - France (Lyon)

Conference by Isabelle Dusanter

Date event : June 14, 2018 - 11:00am Conference / Talk Published on 06/11/2018 - 9:44am

The RNA binding proteins PUMILIO and their target FOXP1, a new signaling pathway to sustain hematopoietic stem cell activity


Isabelle Dusanter

Institut Cochin (Paris Descartes)


RNA-binding proteins (RBPs) have emerged as important regulators of invertebrate adult stem cells, but their activities remain poorly appreciated in mammals. Using a short hairpin RNA strategy, we demonstrate here that the 2 mammalian RBPs, PUMILIO (PUM)1 and PUM2, members of the PUF family of posttranscriptional regulators, are essential for hematopoietic stem/progenitor cell (HSPC) proliferation and survival in vitro and in vivo upon reconstitution assays. 

Thursday 14 June, 11am, SBRI Conference room.

Invited by Pierre Savatier