Journée Nationale des Neurosciences
Published on February 22, 2010
Campagne de sensibilisation grand public sur la place Antonin Poncet Samedi 13 Mars
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| Platforms |
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PrimaStem |
PrimaStem is a biotechnology research platform, joint funded by INSERM and INRA dedicated to deriving embryonic stem (ES) cell lines in non murine species, including rhesus monkey, goat, rabbit, and man. It also aims to develop molecular and cellular tools for conditional gene expression in embryonic stem (ES) cells and their differentiation derivatives. PrimaStem offers training to research teams in the field of non murine ES cell culture and engineering. | |
| Marielle Afanassieff | Derivation and characterization of pluripotent stem cells in non-murine species: primates, rabbit and goat. |
| Mehdi Benchaib | |
| Colette Dehay | Team leader |
| Murielle Godet | Derivation and characterization of epiblast stem cell (EpiSC) lines in rabbit and goat. |
| Jean-François Guerin | |
| Cyril Huissoud | |
| Suzy Markossian | Derivation and characterization of pluripotent stem cell lines (Embryonic stem (ES) cells and induced Pluripotent Stem (iPS) cells) in rabbit and goat. Responsible for cell banking. Engineering of lentiviral vectors. |
| Pierre Osteil EPHE Student | Derivation and characterization of embryonic stem (ES) cell lines in Human, monkey and rabbit. |
| Pierre Savatier | Our team examines the mechanisms of self-renewal and pluripotency in
mouse and human embryonic stem cells. We aim to identify novel genes
involved in the maintenance of the undifferentiated state and in the
early commitment towards ectoderm, mesoderm and endoderm. Another
aspect of our work focuses on the regulation of the cell cycle, which
shows unusual characteristics both in mouse and primate ES cells. We
study the role of regulators of the G1- to S-phase transition in the
maintenance ... |
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Selected Publications of Team members :
Wianny F, Bernat A, Huissoud C, Marcy G, Markossian S, Cortay V, Giroud P, Leviel V, Kennedy H, Savatier P, Dehay C (2008) Derivation and cloning of a Novel Rhesus ES cell line stably expressing Tau-GFP Stem Cells 26(6):1444-53
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Godet M, Sabido O, Gilleron J, Durand P (2008) Meiotic progression of rat spermatocytes requires mitogen-activated protein kinases of Sertoli cells and close contacts between the germ cells and the Sertoli cells. Dev Biol 315:173-88.
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Fluckiger AC, Marcy G, Marchand M, Negre D, Cosset FL, Mitalipov S, Wolf D, Savatier P, Dehay C (2006) Cell cycle features of Primate Embryonic Stem Cells Stem Cells 24(3):547-556
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Afanassieff M, Goto RM, Ha J, Sherman MA, Zhong L, Auffray C, Coudert F, Zoorob R, Miller MM (2001) At least one class I gene in restriction fragment pattern-Y (Rfp-Y), the second MHC gene cluster in the chicken, is transcribed, polymorphic, and shows divergent specialization in antigen binding region. J Immunol 166:3324-33.
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