CORTEX International Meeting 2013
Published on April 22, 2013
LabEx CORTEX is organising an International Conference in Lyon next June....
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PrimaStem |
PrimaStem is a biotechnology research platform, joint funded by INSERM and INRA, dedicated to deriving embryonic stem (ES) and induced pluripotent stem (iPS) cell lines in non murine species, including primates and livestocks. ES cells are derived in the rabbit to develop an ES cell-based transgenic technology in farm animals. ES and iPS cells are derived in human and rhesus monkey. They are used to assess both the efficacy and the safety of cell therapy in a monkey model of Parkinson disease. Beside, PrimaStem offers training to research teams in the field of non murine ES cell culture and engineering. | |
| Marielle Afanassieff | Production of ES and iPS cell lines in livestocks and primates. Development of ES/iPS cell-based transgenesis in the rabbit. |
| Murielle Godet | Production of ES cells in the rabbit. Differentiation into primordial germ cells and transgenesis. |
| Suzy Markossian | Derivation and characterization of pluripotent stem cell lines (Embryonic stem (ES) cells and induced Pluripotent Stem (iPS) cells) in rabbit and goat. Responsible for cell banking. Engineering of lentiviral vectors. |
| Pierre Osteil EPHE Student | Derivation and characterization of embryonic stem (ES) cell lines in Human, monkey and rabbit. |
| Pierre Savatier | Team leader |
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Selected Publications of Team members :
Wianny F, Bernat A, Huissoud C, Marcy G, Markossian S, Cortay V, Giroud P, Leviel V, Kennedy H, Savatier P, Dehay C (2008) Derivation and cloning of a Novel Rhesus ES cell line stably expressing Tau-GFP Stem Cells 26(6):1444-53
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Godet M, Sabido O, Gilleron J, Durand P (2008) Meiotic progression of rat spermatocytes requires mitogen-activated protein kinases of Sertoli cells and close contacts between the germ cells and the Sertoli cells. Dev Biol 315:173-88.
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Fluckiger AC, Marcy G, Marchand M, Negre D, Cosset FL, Mitalipov S, Wolf D, Savatier P, Dehay C (2006) Cell cycle features of Primate Embryonic Stem Cells Stem Cells 24(3):547-556
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Afanassieff M, Goto RM, Ha J, Sherman MA, Zhong L, Auffray C, Coudert F, Zoorob R, Miller MM (2001) At least one class I gene in restriction fragment pattern-Y (Rfp-Y), the second MHC gene cluster in the chicken, is transcribed, polymorphic, and shows divergent specialization in antigen binding region. J Immunol 166:3324-33.
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