CORTEX International Meeting 2013Published on April 22, 2013
LabEx CORTEX is organising an International Conference in Lyon next June....
Pluripotency and Differentiation control of Embryonic Stem cells
The main team project focuses on the chicken ESC and aims to explore the molecular mechanisms underlying self-renewal in the pluripotent state and differentiation into germ cells. Specifically, we aim i) to identify the core pluripotency network in chicken ESCs, ii) to identify the molecular mechanisms that govern differentiation into germ cells, iii) to explore the epigenetic changes that take place in vitro and in vivo during the early development of the chicken embryo, and iv) to reprogram avian somatic cells into pluripotent induced stem cells and germinal stem cells.
| Bertrand Pain || |
Interest in ES cells and early development. Aim to understand the molecular mechanisms that control pluripotency, somatic and germinal differentiation using the chicken embryonic stem cells (cESC) as a non mammalian model system.
| Pauline Aubel || |
| Christian Jean || |
Chicken gene analysis by qPCR and Microarray.
| Franca Raucci || |
| Sophie Voisin || |
Selected Publications of Team members : |
Bouhallier F, Allioli N, Lavial F, Chalmel F, Perrard MH, Durand P, Samarut J, Pain B, Rouault JP. (2010) Role of miR-34c microRNA in the late steps of spermatogenesis. RNA. 16(4): 720-31 download
Lavial F, Pain B (2010) Chicken embryonic stem cells as a non-mammalian embryonic stem cell model Dev Growth Differ. 52(1): 101-14 download
Lavial F, Acloque H, Bachelard E, Nieto MA, Samarut J, Pain B. (2009) Ectopic expression of Cvh (Chicken Vasa homologue) mediates the reprogramming of chicken embryonic stem cells to a germ cell fate. Dev Biol. 330(1): 73-82. download
Lavial F, Acloque H, Bertocchini F, Macleod DJ, Boast S, Bachelard E, Montillet G, Thenot S, Sang HM, Stern CD, Samarut J, Pain B (2007) The Oct4 homologue PouV and Nanog regulate pluripotency in chicken embryonic stem cells. Dev 134(19):3549-3563 download