CORTEX International Meeting 2013Published on April 22, 2013
LabEx CORTEX is organising an International Conference in Lyon next June....
Neurobiology of executive functions
|The mechanisms by which neural networks compute and transfer information is a core issue in neurosciences. Rate, synchronization and oscillations are key mechanisms by which the brain can reliably represent distributed information, as in perceptual binding. How these mechanisms apply to higher cognitive functions is debated.|
Higher cognitive functions (executive functions) require the appropriate interactions of prefrontal areas, striatum and the dopaminergic system. These structures participate in working memory and performance monitoring. Brain imaging shows that dorsolateral prefrontal and anterior cingulate cortices (DLPF & ACC) are co-activated during cognitive tasks, each area forming fronto-striatal loops that are influenced by dopaminergic inputs.
Much of our previous research focused on the neurophysiological correlates of cognitive processing in prefrontal areas. Using single-unit recordings we have shown that the neural coding of intended actions and outcomes are modulated during learning, particular in ACC and DLPF. The dynamics and timing of these modulations is comparable in both areas, although the basic information processed in each is very different. Moreover, the modulation of activity patterns is evocative of those observed in mesencephalic structures that play a key role in learning.
However, the real-time interactions between these structures as well as their modulation by dopaminergic afferents remain essentially unknown. Our current projects aim at exploring how cognitive processes are specified by the activity in each area, by the dynamical interactions between prefrontal cortical areas, and how these interactions are controlled by inputs from the monoaminergic modulatory systems.Our core project is to use multiple techniques (anatomy of connectivity, multi-microelectrodes, EEG, fMRI) to describe the anatomy and function of the networks involved in higher cognitive functions in primates. This project consists in developing a multi-level approach to studying cognitive processes. It involves improving methods and techniques established in U846, as well as developing new technological approaches
| Emmanuel Procyk || |
What are the neural mechanisms producing higher cognitive functions, and in particular those allowing flexible and voluntary behaviours? This is the main theme of my research. It adresses action and outcome valuation, cognitive control / working memory and sequential planning, and how these processes participate to learning and rapid adaptations of behaviour.Understanding these mechanisms requires investigating brain functions from behavioural to basic neurophysiological and neurochemical levels. ...
| Céline Amiez || |
| Julien Benistant Graduate Student|| |
| Kwamivi Dzahini || |
The objectives concern the detection of chemical alterations in the brain and behavioral deficits during early phases of progressive dopaminergic lesion simulating Parkinson’s disease. This in view to ameliorate the diagnostic ability, and to propose new therapeutic processes. This is based on longitudinal approaches using experimental models with 6-OHDA and MPTP, toxic substances of the dopaminergic central neurons.First, Parkinson’s disease etiology is approached. We investigate ...
| Mailys Faraut || |
| Vincent Leviel || |
The objectives concern the detection of chemical alterations in the brain and behavioral deficits during early phases of progressive dopaminergic lesion simulating Parkinson’s disease. This in view to ameliorate the diagnostic ability, and to propose new therapeutic processes. This is based on longitudinal approaches using experimental models with 6-OHDA and MPTP, toxic substances of the dopaminergic central neurons.First, Parkinson’s disease ...
| Marie Rothe PHD Student|| |
I’m interested in understanding how decision making is completed, i.e. how value is computed depending on different reward parameters (probability, cost, quantity, quality, etc.), where different information are stored and analysed to be used and how the different brain regions involved in this process interact. My researches focus on two prefrontal areas (dlPFC and ACC) and consist in studying their activities and interactions during decision making. To understand the mechanisms underlying ...
| Frederic Stoll PhD Student|| |
| Julien Vezoli || |
My research interests lie in the intersection of three fields of neuroscience; from neuroanatomy and neurophysiology to preclinical investigation of cell therapy applied to the progressive model of Parkinson's disease (low-dose mptp).My studies in neuroanatomy are concerned with inter-areal connectivity and brain networks' basic characteristics comprehension. I use the chronic-EEG technique to seek for neurophysiological correlates of cognitive integration ...
| Charlie Wilson || |
I am interested in understanding how the brain produces complex
cognition, in particular cognitive control and adaptation of behaviour,
and how these interact with memory. Specifically, I am interested in the
mechanisms at work in the prefrontal cortex, the ways in which
different cortical regions interact with prefrontal cortex to subserve
these forms of cognition, and the forms that these interactions take. Currently
at SBRI I study cortical oscillations, ...
Selected Publications of Team members : |
Vezoli J, Fifel K, Leviel V, Dehay C, Kennedy H, Cooper HM, Gronfier C, Procyk E (2011) Early Presymptomatic and Long-Term Changes of Rest Activity Cycles and Cognitive Behavior in a MPTP-Monkey Model of Parkinson’s Disease. PLoS ONE 6(8): e23952 download
Vezoli J, Procyk E (2009) Frontal Feedback-Related Potentials in Nonhuman Primates: Modulation during Learning and under Haloperidol J Neurosci 29 (50): 15675-15683 download
Quilodran R, Rothé M, Procyk E (2008) Behavioral shifts and action valuation in the anterior cingulate cortex. Neuron download
Sallet J, Quilodran R, Rothé M, Vezoli J, Joseph JP, Procyk E. (2007) Expectations, gains and losses in the anterior cingulate cortex. Cogn Affect Behav Neurosci 7(4), 327-36. download
Procyk E, Goldman-Rakic PS (2006) Modulation of dorsolateral prefrontal delay activity during self-organized behavior. J Neurosci 26(44):11313-23. download
Amiez C, Joseph JP, Procyk E (2006) Reward Encoding in the Monkey Anterior Cingulate Cortex. Cereb Cortex 16(7):1040-55 download
Amiez C, Joseph JP, Procyk E (2005) Anterior cingulate error-related activity is modulated by predicted reward. Eur J Neurosci 21(12):3447-52 download
Leviel V (2001) The reverse transport of DA, what physiological significance? Neurochem Int 38(2):83-106 download
Procyk E, Joseph JP (2001) Characterization of serial order encoding in the monkey anterior cingulate sulcus Eur J Neurosci 14:1041-6. download