Parution de "Les mécanismes du sommeil"Published on June 19, 2013
Claude Gronfier a participé à l'écriture d'un ouvrage sur le sommeil qui est paru cette semaine...
Neurobiology of circadian rhythms and Sleep
|The research aims of Neurobiological Rhythms and Sleep are focused on the molecular, cellular and behavioral mechanisms of the circadian timing system and the consequences of aging and neurodegenerative disease. Central to our approach is an understanding of the synchronization of circadian rhythms by the external light cycle, the molecular and physiological mechanisms of the endogenous circadian oscillator (SCN), and the regulation of output behavioral and physiological rhythms. The coding of photic information by retinal photoreceptors (rods, cones, melanopsin ganglion cells) are studied using in vivo electrophysiological recording techniques in anaesthetised and awake, freely moving animals. The effects of light (intensity, duration, spectrum) on SCN neuronal activity and on clock gene expression are also assayed using quantitative RT-PCR, laser dissection and microarray analysis. In order to understand the consequences of chronobiological disorders, another line of research involves investigation of the mechanisms of synchronisation of central and peripheral oscillators, including the expression of clock genes and rhythmically expressed clock controlled genes in the brain and in different body tissues. Pathological models investigated in rodents include ocular diseases and Parkinson's disease, and a prosimian primate model of aging. In humans, circadian photoreception and entrainment of the circadian timing system as well as chronobiological disorders related to ocular pathologies, aging and neurodegenerative diseases are studied in the framework of a European integrated project in our clinically based Platform for Research on Human Chronobiology. In order to bridge the gap between cellular-molecular studies in rodent models and clinical studies in humans, the non-human primate is used to study the circadian timing system and sleep wake cycle and, in the framework of the laboratory transversal project, the chronobiological consequences of Parkinson's Disease.|
|Dr. Howard Cooper || |
The research aims of Neurobiological Rhythms and Sleep are focused on the molecular, cellular and behavioral mechanisms of the circadian timing system and the consequences of aging and neurodegenerative disease.Our approaches strive to understand the mechanisms of synchronization of circadian rhythms by lignt, the molecular and physiological mechanisms of the endogenous circadian oscillators, and the regulation of output behavioral and physiological rhythms. The coding of photic information ...
| Christine Coutanson || |
| Philippe Denis || |
| Ouria Dkhissi-Benyahya || |
My research interest is to understand how the circadian system is regulated by light, the role of classical and novel photoreceptors in circadian light perception and the consequences of specific photoreceptor deletions on the functioning of the retinal oscillator and the central endogenous clock. This work include a range of molecular, cellular, anatomical and behavioral approaches.
| Guy Gingras || |
Assessment of visual functions in animal models of human visual disorders.
Keywords: retinal pathologies, gene therapy, recombinant adeno-associated viral vectors (rAVV), melanopsin-expressing retinal ganglion cells, blindness, visual recovery, animal psychophysics, fMRI.
| Claude Gronfier || |
My research projects focus on understanding the mechanisms involved in entrainment of the circadian timing system (a.k.a. the
endogenous biological clock), the physiological consequences of circadian
misalignment (circadian rhythms sleep disorders, space class missions), and the
etiology of circadian and/or sleep disorders in conditions such as ocular
pathologies, neurodegenerative diseases, aging, and shift work. My research
interests also include understanding ...
| Hasna Lahouaoui || |
| Raymond Najjar ||
The aims of my current studies are to investigate the effects of aging and light spectrum modulation on circadian rhythms and sleep. I am also working on a new ophthalmologic system to quantify the gradual ocular lens yellowing.
I am interested in non visual consequences of blindness, studies involving ...
| Petteri Teikari PhD Student|| |
I am interested mainly in the melanopsin-dependent non-image forming (NIF) photoreception and the contribution of classical photoreceptors to NIF-responses.
Keywords: non-image forming visual system, NIF, melanopsin, acute effects of light, alertness, phototransduction, photoreception, pupillary light reflex, pupillometry, vision, lighting, architectural lighting, light, chronobiology, illumination engineering, biomedical engineering, matlab
Selected Publications of Team members : |
Cooper HM, Mure LS (2008) Expected and unexpected properties of melanopsin signalling. J Biol Rhythms 23(5): 392-93 download
Hut RA, Oklejewicz M, Rieux C, Cooper HM. (2008) Photic sensitivity ranges of hamster pupillary and circadian phase responses do not overlap. J Biol Rhythms 23: 37-48. download
Drouyer E, Rieux C, Hut RA, Cooper HM (2007) Responses of SCN neurons to light and dark adaptation: relative contributions of melanopsin and rod-cone inputs. J Neurosci 27(36): 9623-31. download
Dkhissi-Benyahya O, Gronfier C, De Vanssay W, Flamant F, Cooper HM (2007) Modeling the role of mid-wavelength cones in circadian responses to light. Neuron 53(5):677-87. download
Gronfier C, Wright KP Jr, Kronauer RE, Czeisler CA (2007) Entrainment of the human circadian pacemaker to longer-than-24-h days. Proc Natl Acad Sci U S A, 104(21):9081-6 download
Mure LS, Rieux C, Hattar S, Cooper HM. (2007) Melanopsin-dependent nonvisual responses: evidence for photopigment bistability in vivo J Biol Rhythms 22(5): 411-24 download
Canaple L, Rambaud J, Dkhissi-Benyahya O, Rayet B, Tan NS, Michalik L, Delaunay F, Wahli W, Laudet V (2006) Reciprocal regulation of BMAL1 and PPARa defines a novel positive feedback loop in the murine liver circadian clock. Mol Endocrinol 20(8):1715-27 download
Dkhissi-Benyahya O, Rieux C, Hut RA, Cooper HM. (2006) Immunohistochemical evidence for a melanopsin cone in human retina. IOVS, 47(4):1636-41. download
Gronfier C, Wright KP, Jewett ME, Kronauer RE, Czeisler CA (2004) Efficacy of a single sequence of intermittent bright light pulses for delaying circadian phase in humans. Am J Physiol Endocrinol Metab, 287:E174-E181. download
Glickman G, Hanifin J, Rollag MD, Wang J, Cooper HM, Brainard GC. (2003) Inferior retinal light exposure is more effective than superior retinal exposure in suppressing melatonins in humans J. Biol Rhythms, 18(1):71-79. download
Chiquet C, Dkhissi-Benyahya O, Szel A, Degrip WJ, Cooper HM (2002) Characterisation of calbindin positive cones in four primate species. Neuroscience. 115(4):1323-33. download
Rieux C, Carney R, Lupi D, Dkhissi-Benyahya O, Janssen K, Cooper HM. (2002) Analysis of immunohistochemical label of Fos protein in the suprachiasmatic nucleus: comparison of different methods of quantification. J. Biol. Rhythms. 17(2): 121-136. download
Brandenberger G, Gronfier C, Chapotot F, Simon C, Piquard F (2000) Effect of sleep deprivation on overall 24h growth hormone secretion Lancet suppl download
Dkhissi-Benyahya O, Sicard B, Cooper HM (2000) Effects of irradiance and stimulus duration on early gene expression (Fos) in the suprachiasmatic nucleus : temporal summation and reciprocity. J Neurosci 20(20):7790-7. download