Postnatal forebrain development and plasticity
The mechanisms that regulate the generation of neuronal diversity in the developing central nervous system (CNS) have been extensively studied. These studies have shown that both the spatial and temporal origins of precursors determine their neurotransmitter phenotype, firing properties, subtype specification and the position of the cell body in different regions and different layers.
You can also find relevant information about this team here.
|Dr Olivier Raineteau || |
| Diane Angonin || |
Diane combines fate mapping techniques with targeted lesions of defined olfactory bulb neuronal subtypes, in order to test the regenerative potential of early postnatal subventricular zone progenitor populations. She is also interested in testing the effects of canonical Wnt stimulation to promote dorsal progenitor fates (oligodendroglial and glutamatergic) in health and diseases.
| Vanessa Donega || |
During my PhD I investigated the potential of intranasal mesenchymal stem cell administration to promote regeneration of the postnatal brain following a hypoxic-ischemic insult. I joined the lab as a Post-Doctoral researcher to study the response of defined progenitor populations to neonatal hypoxia, and if their participation to tissue repair can be encouraged by pharmacological stimulation of signaling pathways.
| Elodie Gaborieau || |
Elodie focuses on the molecular control of progenitors proliferation in the postnatal subventricular zone. A long term aim of her work consists in understanding the relations that may exist between progenitor’s proliferative behavior and acquisition of defined fates.
| Guillaume Marcy PhD Student|| |
Guillaume’s work aims at addressing postnatal subventricular zone progenitor’s competence, i.e. their capacity to generate a diversity of cell type. To this end, he is using two approaches: 1) heterotypic/heterochronic transplantations; 2) targeted ablations of defined neuronal subtypes.
| Stefan Zweifel || |
Stefan’s work aims at identifying transcription factors that actively participate into the regionalization of the postnatal subventricular zone. He is currently focusing on transcription factors that are enriched in the dorsal most microdomains of this germinal region, where they may control neuronal vs. glial fate choice.
Selected Publications of Team members : |
Orlando C, Raineteau O (2015) Integrity of cortical perineuronal nets influences corticospinal tract plasticity after spinal cord injury Brain Struct Funct. 2015 Mar;220(2):1077-91
Azim K, Hurtado-Chong A, Fischer B, Kumar N, Zweifel S, Taylor V, Raineteau O. (2015) Transcriptional Hallmarks of Heterogeneous Neural Stem Cell Niches of the Subventricular Zone Stem Cells. 2015 Jul;33(7):2232-42
Amrein I, Nosswitz M, Slomianka L, van Dijk RM, Engler S, Klaus F, Raineteau O, Azim K (2015) Septo-temporal distribution and lineage progression of hippocampal neurogenesis in a primate (Callithrix jacchus) in comparison to mice Front Neuroanat. 2015 Jun 29;9:85. doi: 10.3389/fnana.2015.00085. eCollection 2015
Azim K, Fischer B, Hurtado-Chong A, Draganova K, Cantu C, Zemke M, Sommer L, Butt A, Raineteau O (2014) Persistent Wnt/b-Catenin signaling determines dorsalization of the postnatal subventricular zone and neural stem cell specification into oligodendrocytes and glutamatergic neurons Stem Cells, 32(5):1301-12