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Conference by Adrien Meguerditchian

Published on March 28, 2017

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Investissements d'Avenir : Cesame - Plateforme d'ingénierie cellulaire


Brain, Mind and Health Institute, is located in Lyon, France, and led by Neurodis Foundation. The French Government with the “Investment for Future” program supports the Institute. CESAME Institute aims at developing research and therapies in neurology and neuropsychiatry for the benefit of patients. The Institute works to bridge brain and mind health creating synergy between: neuroscience, psychiatry and social science and humanities. Its actions come in the following research themes:

• Global understanding of brain functioning: neural
development, optogenetics…
• Brain and mind diseases understanding: neural network dysfunctions, degeneration, cognitive disorders, and abnormal
brain excitability in pain, epilepsy and mental diseases…
• Therapies enhancements, for example: brain repair, remediation,
neuroprotection, readaptation, new technological solutions using brain-computer interfaces…

CESAME Institute gathers five high technological facilities:

• Cell engineering and gene transfer facility aims at improving stem cell-based therapeutic
strategies of neurodegenerative diseases and implementing gene transfer in non human primate
models suffering from retinal defects, and for progressing in understanding the mechanisms of
brain development and plasticity.
• Blood-brain interface facilty develops in vitro, ex vivo and in vivo models for understanding bloodbrain
interface functions, which is a key issue to improve the bioavailability of Central Nervous System
(CNS) therapeutic agents to validate their therapeutic targets and to decrease the side effects of drugs on
• Human brain signal facility permits to record and analyse intracerebral EEG (iEEG) in epileptic
patients candidates to epilepsy surgery thus offering a unique opportunity to record neural activity
throughout the human brain with optimal time and anatomical resolution and permitting a real-time
monitoring of interactions between brain and environment.
• Neuro-immersion facility develops innovative strategies for rehabilitation of neurological,
cognitive and psychiatric disorders via the coupling of immersive virtual reality, neurostimulation
systems and state-of-art neuroscience tools.
• Neuro-imaging facility develops new radio-ligands and image analysis software for Positon
Emission Tomography (PET) and functional Magnetic Resonance Imaging (fMRI) for brain studies
using the first fully simultaneous 3Tesla MRI-PET installed in France.

For further information, click here.


Colette Dehay

Team leader

Pierre Savatier

DR2 INSERM, Team leader. He obtained his PhD from the University of Lyon in 1986. He joined INSERM in 2004 as an AVENIR team leader, and the same year he was awarded the “Coup d’Elan pour la recherche” from the Bettencourt Foundation. His team participates in two laboratory of excellence (LabEx): DEVweCAN and CORTEX. His is responsible for PrimaStem, a technological platform specialized in pluripotent stem cells in primates. PrimaStem participates ...

Selected Publications of Team members :