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Conference by Adrien Meguerditchian

Published on March 28, 2017

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Cortical architecture, coding and perception


We investigate information processing in the cortical networks underlying visual perception and visuo-motor integration. We have established the statistical tools for modelling connectivity underlying the hierarchical organization of the cortex, and are exploring the context-dependent processing that these results suggest. Cortical networks are identified using fMRI, both in human and non-human primates. Psychophysics allows inference about the computational properties and when coupled with fMRI allows the localisation of the sites of these computations in cortical networks. The fMRI in the monkey makes it possible to understand functional networks in humans in terms of the cellular mechanisms established by studies carried out in the monkey. Developmental, aging and pathological models are also used to explore the independence and interactions of visual functions with performance. Finally, we apply the results from this approach to the design of stimuli and training procedures in order to improve performance related to visual tasks in observers with low vision.

Henry Kennedy

SBRI investigates the development, function and repair of neuronal circuits involved in cognition, motor control and biological rhythms and researches the structural foundations of computation in the cortex. We seek to develop embryonic stem cell based therapies so as to reverse the effects of brain lesions leading to the motor and cognitive deficits found in neurological disease including Parkinson's.

Kenneth Knoblauch

Perception and sensory coding, color vision, psychophysics, functional cerebral imagery, low vision, development of visual function, modeling of neural processes and networks.

Clement Abbatecola PhD student

Multimodal integration in face and voice perception, prosopagnosia, relation between brain networks structure and cognitive functions, fMRI data analysis.

Jennifer Beneyton


Bianca Gamanut

Razvan Gamanut PhD Student

Peggy Gerardin

Szabolcs Horvát

Melle Isabelle Koy

Camille Lamy

A major part of my work in the team concerns the development of a so called frameless stereotaxy or neuronavigation system, the “Brainsight Primate”. This system makes it possible to perform very precise intracerebral injections of neuronal tracers or place probes, electrodes etc. in buried ...

Loïc Magrou PhD student

Pierre Misery

I am working on the cortico-cortical connectivity of the macaque. We use retrograde tracers to examine topography of interareal connectivity. To do this, we inject tracers in the brain of macaque using MRI guided technology (Brain Sight). We carry out histological processing on the brain so as to accurately allocate labelled neurons to particular cortical areas.An important aspect of the analysis of the material is the recording of the XY coordinates ...

Julie Muguet

Ana Rita Ribeiro Gomes PhD Student

The brain is composed of different anatomical pathways that link different brain regions, in order to establish channels of communication/interaction between them. I have developed my scientific activity in the field of neuroanatomy and cortical network, in particular in the study of cortico-cortical and subcortical-cortical connectivity in the macaque by the use of fluorescent retrograde tracers. These markers are injected in different cortical areas and are actively transported from ...

Duo Xiao

Selected Publications of Team members :
Michalareas G., Vezoli J., Van Pelt S., Schoffelen JM, Kennedy H., Fries F. (2016) Alpha-Beta and Gamma Rhythms Subserve Feedback and Feedforward Influences among Human Visual Cortical Areas. Neuron, Epub ahead of print 10.1016/j.neuron.2015.12.018.
Wang XJ, Kennedy H. (2016) Brain structure and dynamics across scales : in search of rules. Curr Opin Neurobiol, 37 :92-98
Fame RM, Dehay C, Kennedy H, Macklis JD (2016) Subtype-specific genes that characterize subpopulations of callosal projection neurons in mouse identify molecularly homologous populations in macaque cortex. Cereb Cortex, in press 10.1093/cercor/bhw023
Chad J. Donahue, Stamatios N. Sotiropoulos, Saad Jbabdi, Moises Hernandez-Fernandez, Timothy E. Behrens, Tim B. Dyrby, Timothy Coalson, Henry Kennedy, Kenneth Knoblauch, David C. Van Essen, Matthew F. Glasser. (2016) Using Diffusion Tractography to Predict Cortical Connection Strength and Distance: A Quantitative Comparison with Tracers in the Monkey. The Journal of Neuroscience, June 22, 2016, 36(25):6758–6770 download
Bellot E, Coizet V, Warnking J, Knoblauch K, Moro E, Dojat M (2016) Effects of aging on low luminance contrast processing in humans. NeuroImage 139 (2016) 415–426
Bastos AM, Vezoli J, Bosman CA, Schoffelen JM, Oostenveld R, Dowdall JR, De Weerd P, Kennedy H, Fries P (2015) Visual areas exert feedforward and feedback influences through distinct frequency channels. Neuron 85:390-401
Varnet L, Knoblauch K, Serniclaes W, Meunier F, Hoen M (2015) A psychophysical imaging method evidencing auditory cue extraction during speech perception: a group analysis of auditory classification images PLoS One. 2015 Mar 17;10(3):e0118009
Ji W., Gamanut R., Bista P., D’Souza R. D., Wang Q., Burkhalter A. (2015) Modularity in the Organization of Mouse Primary Visual Cortex. Neuron, 87(3), 632–643.
Chaudhuri R, Knoblauch K, Gariel MA, Kennedy H, Wang XJ (2015) A large-scale circuit mechanism for hierarchical dynamical processing in the primate cortex. Neuron 88:419-431
Markov NT, Ercsey-Ravasz MM, Ribeiro Gomes AR, Lamy C, Magrou L, Vezoli J, Misery P, Falchier A, Quilodran R, Gariel MA, Sallet J, Gamanut R, Huissoud C, Clavagnier S, Giroud P, Sappey-Marinier D, Barone P et al (2014) A weighted and directed interareal connectivity matrix for macaque cerebral cortex. Cereb Cortex, 2014, 24(1):17-36 download
Markov NT, Vezoli J, Chameau P, Falchier A, Quilodran R, Huissoud C, Lamy C, Misery P, Giroud P, Ullman S, Barone P, Dehay C, Knoblauch K, Kennedy H. (2014) The anatomy of hierarchy: Feedforward and feedback pathways in macaque visual cortex. J Comp Neurol, 2014, 522(1):225-259 download
Markov N.T., Ercsey-Ravasz M., Lamy C., Ribeiro-Gomes A.R., Magrou L., Misery P., Giroud P. Barone P., Dehay C., Toroczkai Z., Knoblauch, K., Van Essen D.C., Kennedy H. (2013) The role of long-range connections on the specificity of the macaque interareal cortical network. Proc Nat Acad Sci USA, 2013, 110, 5187-5192 download
Markov NT, Kennedy H (2013) The importance of being hierarchical. Curr Opin Neurobiol 2013, 2:187-194 download
Kennedy H, Knoblauch K, Toroczkai Z (2013) Why data coherence and quality is critical for understanding interareal cortical network? Neuroimage 80: (37-45) download
Ercsey-Ravasz M, Markov NT, Lamy C, Van Essen DC, Knoblauch K, Toroczkai Z, Kennedy H (2013) A Predictive Network Model of Cerebral Cortical Connectivity Based on a Distance Rule. Neuron 80:184-197 download
Markov NT, Ercsey-Ravasz M, Van Essen DC, Knoblauch K, Toroczkai Z, Kennedy H. (2013) Cortical high-density counter-stream architectures. Science 342:1238406 download
Betizeau M, Cortay V, Patti D, Pfister S, Gautier E, Bellemin-Ménard A, Afanassieff M, Huissoud C, Douglas RJ, Kennedy K, Dehay C (2013) Precursor Diversity and Complexity of Lineage Relationships in the Outer Subventricular Zone of the Primate. Neuron 80 :442-457 download
Kennedy H, Knoblauch K, Toroczkai Z (2013) Data coherence and completion actually do count for interareal cortical network. Neuroimage, 2013, 80:37-45
Markov NT, Misery P, Falchier A, Lamy C, Vezoli J, Quilodran R, Gariel MA, Giroud P, Ercsey-Ravasz M, Pilaz LJ, Huissoud C, Barone P, Dehay C, Toroczkai Z, Van Essen DC, Kennedy H, Knoblauch K (2011) Weight Consistency Specifies Regularities of Macaque Cortical Networks. Cereb Cortex. 2011, 21:1254-1272 download
Vezoli J, Fifel K, Leviel V, Dehay C, Kennedy H, Cooper HM, Gronfier C, Procyk E (2011) Early Presymptomatic and Long-Term Changes of Rest Activity Cycles and Cognitive Behavior in a MPTP-Monkey Model of Parkinson’s Disease. PLoS One, 2011, 6(8):e23952 download
Anderson JC, Kennedy H, Martin KA (2011) Pathways of attention: synaptic relationships of frontal eye field to v4, lateral intraparietal cortex, and area 46 in macaque monkey. J Neurosci., 2011, 31: 10872-10881 download
Markov NT, Ercsey-Ravasz MM, Gariel MA, Dehay C, Knoblauch A, Toroczkai Z, Kennedy H (2011) The tribal networks of the cerebral cortex. In: Cerebral Plasticity (Chalupa LM, Berardi N, Caleo M, Galli-Resta L, Pizzorusso T, eds), p 275-290. Cambridge MA: MIT Press.
Dehay C, Kennedy H (2007) Cell-cycle control and cortical development. Nat Rev Neurosci, 2007, 8(6):438-50 download
Clavagnier S, Prado J, Kennedy H, Perenin MT (2007) How humans reach: distinct cortical systems for central and peripheral vision. Neuroscientist, 2007, 13:22-27 download
Knoblauch K, Neitz M, Neitz J (2006) An urn model of the development of L/M cone ratios in human and macaque retinas Visual Neurosci 23:387-394 download
Dojat M, Piettre L, Delon-Martin C, Pachot-Chouard M, Segebarth C, Knoblauch K (2006) Global Integration of local color differences in transparency perception: an fMRI study. Vis Neurosci 23(3-4):357-64 download
Lukaszewicz A, Savatier P, Cortay V, Giroud P, Huissoud C, Berland M, Kennedy H, Dehay C (2005) G1 phase regulation, Area-Specific cell cycle control, and Cytoarchitectonics in the Primate Cortex. Neuron, 2005, 47:353-364 download
Prado J, Clavagnier S, Otzenberger H, Scheiber C, Kennedy H, Perenin MT (2005) Two cortical systems for reaching in central and peripheral vision. Neuron, 2005, 48:849-858 download
Obein G, Knoblauch K, Vienot F (2004) Difference scaling of gloss : Non-linearity, binocularity and constancy. J Vision 4:711-720 download
Bouet R, Knoblauch K (2004) Perceptual classification of chromatic modulation. Vis Neurosci 21:283-9 download
Vezoli J, Falchier A, Jouve B, Knoblauch K, Young M, Kennedy H (2004) Quantitative analysis of connectivity in the visual cortex: extracting function from structure. Neuroscientist, 2004, 10:476-82 download
Clavagnier S, Falchier A, Kennedy H. (2004) Long-distance feedback projections to area V1: Implications for multisensory integration, spatial awareness, and visual consciousness. Cog Affect Behav Neurosci, 2004, 4(2) 117-126 download
Falchier A, Clavagnier S, Barone P, Kennedy H (2002) Anatomical evidence of multimodal integration in primate striate cortex. J Neurosci, 2002, 22 :5749-5759 download
Knoblauch K, Shevell SK (2001) Relating cone signals to color appearance : Failure of monotonicity in yellow / blue. Vis Neurosci 18:901-6 download
Barone P, Batardière A, Knoblauch K, Kennedy H (2000) Laminar distribution of neurons in extrastriate areas projecting to V1 and V4 correlates with the hierarchical rank and indicates the operation of a distance rule. J Neurosci, 2000, 20(9):3263-3281 download
Wefers CJ, Dehay C, Berland M, Kennedy H, Chalupa L. (2000) Retinogeniculate axons in the fetal monkey develop normally after termination of prenatal binocular competition. J Comp Neurol, 2000, 427:362-369
Batardière A, Barone P, Dehay C, Kennedy H (1998) Area-specific laminar distribution of cortical feedback neurons projecting to cat area 17: Quantitative analysis in the adult and during ontogeny. J Comp Neurol, 1998, 396:493-510 download