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Conference by Adrien Meguerditchian

Published on March 28, 2017



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 Platforms 

Chronobiology

 

Human chronobiology Research facility (Hospital Edouard Herriot, Lyon):
    Research facility for short to long-term clinical studies of the human circadian timing system and sleep in complete time isolation. Studies conducted in the facility are focused on understanding the effects of light on sleep, circadian and non-visual physiology, in healthy young and aged individuals, in patients with ocular diseases, and in shift workers. The facility is affiliated to the network of European Centres on Human Chronobiology. Local teams investigating sleep physiology have indicated an interest in conducting human studies in the facility.
    Facility/equipment includes 3 rooms (~250 m2), 4 beds, 3 computer-controlled ganzfled-type lighting setup for photic exposure, 3 digital polysomnography devices for sleep and wake EEG/ECG recordings, 1 experimental head-mounted device for pupillary reflex recording, devices for temperature recording, 3 laptop computers for cognitive and memory testing, equipment for visual evaluation (color vision, acuity, contrast), equipment for biological sample processing (refrigerated centrifuge, freezer).

Human non-visual physiology Research facility (Inserm U846, Bron):
Research facility for short studies of human visual and non-visual physiology. Studies conducted in the facility are focused on understanding the effects of light the pupillary light reflex on sleep, circadian and non-visual physiology, in healthy young and aged individuals, in patients with ocular diseases, and in shift workers. The facility is affiliated to the network of European Centres on Human Chronobiology. The facility also include a setup to measure lens density in vivo in humans. Local ophthalmologists have indicated an interest in having lens density measured in their patients. A patent is currently being field on the lens density method and setup.
    Facility/equipment includes 2 rooms (~20 m2), 1 computer-controlled setup for pupillary reflex recordings, 1 computer controlled setup for lens density measurement, 2 spectrophotometers, 2 luxmeters, 1 photometer.



Dr. Howard Cooper

The research aims of Neurobiological Rhythms and Sleep are focused on the molecular, cellular and behavioral mechanisms of the circadian timing system and the consequences of aging and neurodegenerative disease.Our approaches strive to understand the mechanisms of synchronization of circadian rhythms by lignt, the molecular and physiological mechanisms of the endogenous circadian oscillators, and the regulation of output behavioral and physiological rhythms. The coding of photic information ...

Christine Coutanson

Claude Gronfier

My research focuses on how light synchronizes physiology, including the circadian timing system, to the 24h day in humans.  My projects investigate the mechanisms involved in non-visual photoreception, the effects of light on physiological functions (alertness, cognition, mood), and how light could be used/designed to treat circadian, mood, vigilance, and sleep disorders, in shiftwork and pathological conditions (Ocular diseases, neurodegenerative ...

Abhishek Prayag

My current research interests lies in deciphering the contribution of the rods, cones and melanopsin-ganglion cells in the computation of non-visual responses at the level of the human brain. At the retinal interface, signals coming from the classical photoreceptors and melanopsin cells interact to elicit a wide range of responses in the brain, including crucially: the circadian system, sleep architecture, temperature regulation, hormonal levels, cognitive performance ...

Selected Publications of Team members :