CORTEX International Meeting 2013Published on April 22, 2013
LabEx CORTEX is organising an International Conference in Lyon next June....
|Research facility for short to long-term clinical studies of the human circadian timing system and sleep in complete time isolation. In humans, circadian photoreception, and the consequences of ocular pathologies and aging on the circadian timing system and sleep are also studied in the framework of a European integrated project with links to the network European Affiliated Centres for Human Chronobiology.
The Department of Chronobiology, in collaboration with various hospital teams, initiated the development in 1999 the Platform for Research on Human Chronobiology which is located in the Ophthalmology Clinic (HEH, Lyon). The aims of the facility for investigation of the circadian timing system and its disorders in humans (hyperlink to PDF/PPT). The initial impetus for the facitility came form an FP4 research program ("Human Circadian Photoreception" coord. HM Cooper), collaboration with Bruno Claustrat in the Radioanalysis Service for hormonal assays, and the involvement of Masters-PhD training of two MD's (C Chiquet, F Guerillon). A contract with Allergan Inc (Irvine) encouraged the beginning of our research in the area of glaucoma and ocular pathologies in which Cristophe Chiquet has been very active. Thanks to Christophe, new collaborations have been established with Dr. JP Romanet (CHU, Grenoble) and an MD from Lyon (PL Cornut) who will continue these clinically oriented studies. The human research facility was significantly reinforced with the arrival in 2003 of Claude Gronfier after a post-doctoral stay in Harvard University, where he was involved in large scale projects with NASA for synchronising astronates rhythms to the harsh conditions of missions in space. In Lyon, Claude initiated his studies on the alteration of circadian rhythms in the elderly in the framework of an FP5 grant (OldClock) and is now in charge of the running and future development of the facility. We seek to reinforce our competitiveness in human basic and clinical research by consolidating the available resources for longer term, more detailed studies, which are of interest both locally in Lyon and internationally. |
Starting in 2006, the team is engaged in a new major 5-year FP6 integrated project (EUCLOCK) which involves 23 laboratories and 6 companies in Europe. Our Lyon facility is embedded in the European network of "Affiliated Centres for Human Chronobiology". In the framework of EUCLOCK, our laboratory will be collaborate with several industrials companies in the development of a ambulatory recording devices (Clockwatcher, MEDCARE (NL), SOWOON Technologies (CH) which will record multiple physiological parameters (actimetry, light intensity, respiration, ECG, posture, etc.) with the aim to develop a mathematical model able to predict the circadian phase (biological time) of an individual. Collaboration with Bűhlmann (CH) is also planned for the development of a rapid portable melatonin assay system. Furthermore, a submitted proposal for a Marie Curie Research trainingNetwork "RTN" (coordinator: HM Cooper) will contribute to establish Lyon as a European hub for Chronobiological Research of interest to both the local and international community.
| Bruno Claustrat || |
|Dr. Howard Cooper || |
The research aims of Neurobiological Rhythms and Sleep are focused on the molecular, cellular and behavioral mechanisms of the circadian timing system and the consequences of aging and neurodegenerative disease.Our approaches strive to understand the mechanisms of synchronization of circadian rhythms by lignt, the molecular and physiological mechanisms of the endogenous circadian oscillators, and the regulation of output behavioral and physiological rhythms. The coding of photic information ...
| Claude Gronfier || |
My research projects focus on understanding the mechanisms involved in entrainment of the circadian timing system (a.k.a. the
endogenous biological clock), the physiological consequences of circadian
misalignment (circadian rhythms sleep disorders, space class missions), and the
etiology of circadian and/or sleep disorders in conditions such as ocular
pathologies, neurodegenerative diseases, aging, and shift work. My research
interests also include understanding ...
| Raymond Najjar ||
The aims of my current studies are to investigate the effects of aging and light spectrum modulation on circadian rhythms and sleep. I am also working on a new ophthalmologic system to quantify the gradual ocular lens yellowing.
I am interested in non visual consequences of blindness, studies involving ...
Selected Publications of Team members : |
Pina G, Brun J, Tissot S, Claustrat B (2010) Long-term alteration of daily melatonin, 6-sulfatoxymelatonin, cortisol ad temperarure profiles in burn patients: a preliminary report Chronobiology International, 27(2): 378-392 download