| Transversal projects
Cell replacement therapy for early Parkinsonís disease
The transversal project of the Stem-cell and Brain Research Institute aims at evaluating the efficiency of early cell grafting in the early stages in a pre-clinical model of Parkinson’s disease. The project is implemented using precise motor, cognitive, and circadian assessments of the early stages of the disease, as well as the derivation and characterisation of appropriately defined cell lines for grafting.
|Dr. Howard Cooper || |
The research aims of Neurobiological Rhythms and Sleep are focused on the molecular, cellular and behavioral mechanisms of the circadian timing system and the consequences of aging and neurodegenerative disease.Our approaches strive to understand the mechanisms of synchronization of circadian rhythms by lignt, the molecular and physiological mechanisms of the endogenous circadian oscillators, and the regulation of output behavioral and physiological rhythms. The coding of photic information ...
| Colette Dehay || |
| Henry Kennedy || |
SBRI investigates the development, function and repair of neuronal circuits involved in cognition, motor control and biological rhythms and researches the structural foundations of computation in the cortex. We seek to develop embryonic stem cell based therapies so as to reverse the effects of brain lesions leading to the motor and cognitive deficits found in neurological disease including Parkinson's.
| Florence Wianny || |
My research interests include neural stem cells derived from Embryonic Stem cells in the non-human primate, the study of their self-renewal, and their differential potential.
Selected Publications of Team members : |
Fifel K, Vezoli J, Dzahini K, Claustrat B, Leviel V, Kennedy H, Procyk E, Dkhissi-Benyahya O, Gronfier C, Cooper HM (2014) Alteration of daily and circadian rhytms following dopamine depletion in MPTP treated Non-Human Primates. PLoS One, 2014, 9(1):e86240
Vezoli J, Dzahini K, Costes N, Wilson CR, Fifel K, Cooper HM, Kennedy H, Procyk E (2014) Increased DAT binding in the early stage of the dopaminergic lesion: a longitudinal [11C]PE2I binding study in the MPTP-monkey. Neuroimage 102:249-261
Vezoli J, Fifel K, Leviel V, Dehay C, Kennedy H, Cooper HM, Gronfier C, Procyk E (2011) Early Presymptomatic and Long-Term Changes of Rest Activity Cycles and Cognitive Behavior in a MPTP-Monkey Model of Parkinsonís Disease. PLoS One, 2011, 6(8):e23952 download