Olivier Raineteau Team Leader / DR2
Our laboratory investigates lineage specification in the postnatal SVZ, the main germinal zone of the postnatal forebrain. We have participated to the demonstration that the SVZ is not a homogeneous germinal region, but is composed of microdomains that have different embryonic origins, distinct transcriptional signatures and are biased in generating specific neural cell types (reviewed in (Fiorelli et al 2015)).
Over the last few years, we have progressively focused on characterizing the dorsal-most domain of the postnatal SVZ (dorsal SVZ or dVSZ). This region is particularly interesting as it continues producing cells of distinct lineages, including distinct neuronal lineages. In particular, this region contains progenitors of oligodendrocytes and glutamatergic neurons, two cells type that are particularly sensitive to degeneration in a variety of pathologies.
By using a combination of molecular and imaging tools, our research addresses the following aims:
|2017||15(3):e2000698||Pharmacogenomic identification of small molecules for lineage specific manipulation of subventricular zone germinal activity||Azim K, Angonin D, Marcy G, Pieropan F, Rivera A, Donega V, Cantu C, Williams G, Berninger B, Butt AM, Raineteau O||PLoS Biol||-|
|2017||i-11||Postnatal Neural Stem Cells: Probing their competence for cortical repair||Donega V, Raineteau O||The Neuroscientist||-|
|2015||33(7):2232-42||Transcriptional Hallmarks of Heterogeneous Neural Stem Cell Niches of the Subventricular Zone||Azim K, Hurtado-Chong A, Fischer B, Kumar N, Zweifel S, Taylor V, Raineteau O||Stem Cells||-|
|2015||142(12):2109-20||Adding a spatial dimension to postnatal ventricular-subventricular zone neurogenesis||Fiorelli R, Fischer B, Azim K, Raineteau O||Development||-|