SBRI SAB international meeting coming up next June
Investissements d'avenir: DevWeCan, CORTEX et INGESTEM
Conference by Richard Murray
Published on May 9, 2012
Richard Murray will present his latest work on June 14th in the SBRI conference room...
read more
Project_ Brain Signals UNIT/LFP
What are the relationships between the multiple levels at which brains signals are recorded? unit activity, local filed potentials, surface EEG, MEG, and Bold are signals used to study brain functions at different scales; but how do they relate to each other?
Our studies on prefrontal functions take advantage of different technologies to analyse different levels of neurophysiological signals. When we started to study the coding properties of high gamma LFP oscillations in ACC we faced one intriguing question: what is the contribution of the different electrophysiological phenomena observed at the synapse or cell levels, to the local or global scale signals we study with LFP, sEEG, and EEG? This is of fundamental interest, a long standing question, but it is also an important issue to understand the origin of signals obtained from human recordings. High gamma oscillations reflect functional specificities in different brain areas of patients implanted with cortical or intracerebral electrodes.
One specific debate concerns the origin of high gamma oscillations, which seems to correlate with fMRi Bold signals.
Together with Marie Rothé and in collaboration with Olivier Bertrand (Inserm U821) we decided to address the question of relationships between spike, multi-spike, and LFP oscillations. The project has started and first addresses the following questions:
- What are the spike frequency decompositions (depending on spike shapes and frequency)? how do they contribute to high gamma, and at low level or at lower levels?
- Can we observe cases of independency between unit firing and high Gamma oscillation, in particular during behavior?
 Back |
 |