SBRI SAB international meeting coming up next June
Investissements d'avenir: DevWeCan, CORTEX et INGESTEM
Conference by Richard Murray
Published on May 9, 2012
Richard Murray will present his latest work on June 14th in the SBRI conference room...
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Project_ Prefrontal cortico-cortical interactions
The NEF lab is particularly interested in the study of cortico-cortical relationships underlying adaptative cognitive functions. The dynamics of activity within ACC and DLPF and between these prefrontal regions are at the center of our investigations.
fMRI and unit recordings suggest important interactions between dACC and DLPFC. However the nature of these interactions remains unclear. Determining the relative contributions of indirect modulations through, for example, dopaminergic or noradrenergic systems, or via direct transfer of information through cortico-cortical connections, or as a result of a more complex transfer of information between fronto-striatal-loops, is a key general issue for cognitive neuroscience. The system formed by dACC and DLPFC might be a good place to start to study the complex interplay between distant cortical areas, and between conceptually individualized cognitive processes.
Our data strongly suggest that very fast transfer of information occurs between dACC and DLPFC after behaviourally significant external events (e.g. negative feedback). But they also suggest that there might be quick changes in the types of relationships between the two areas once these key events have been integrated.
With Charles Wilson, Fredéric Stoll, René Quilodran, and Marie Rothé we address these issues studying ECoG, extracellular units, and LFP recordings over large scale network, or in prefrontal areas during adaptive behaviours
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