SBRI Stem-cell and Brain Research Institute - France (Lyon)

Conference by Takuya Hayashi

Date event : June 15, 2018 - 11:00am Conference / Talk Published on 06/05/2018 - 9:35am

Towards NHP connectome using non-invasive multimodal imaging

 

Takuya Hayashi
 

Brain Connectomics Imaging Laboratory, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan

 

The non-human primate (NHP) species is an important neuroscientific model for understanding neuroanatomy, function, connectivity of human brain. Although humans and NHPs are in the same taxonomic group, their evolution were diverged long time ago – it has been 35 million and 25 million years since humans were separated from marmosets and macaques respectively. There have been attempts using non-invasive imaging to address how human brain is different from NHPs. However, a full picture of cross-species homologies is yet to be established to understand the macro-scale cortical architecture and connectome. Recent advancement of MRI such as high gradient hardware, data acquisition and preprocessing opened the way to address parcellation and connectome in living human brain like done in human connectome project (HCP). We have been recently developing the MRI techniques for NHP connectome using a 3T MRI scanner (Autio et al, Hori et al, Yoshida et al. ISMRM 2018). The RF coils provided high SNR whole-brain coverage and allowed parallel imaging with high speed acquisitions of functional and diffusion MRI. Combined with the NHPHCP preprocessing pipelines, multimodal properties of structure and function in the gray matter were robustly mapped onto cross-species standardized coordinates, ‘grayordinates’. The connectivity analyzed by these noninvasive techniques is comparable with those by neuronal tracer, and potentially reveals individual and temporal variability. These applications suggest potential of the NHP connectome project to find valid methods and models and to understand dynamics of primate connectome in evolution, sociality and plasticity.

Friday 15 June, 11am, SBRI Conference room.

Invited by Henry Kennedy