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Conference by Adrien Meguerditchian

Published on March 28, 2017

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Pierre-Yves Bourillot

Position: Research Associate

Company: Inserm u846

Mailing Address:
18 av du Doyen Jean Lepine

69675 - Bron Cedex - France
External Link:

Pluripotent stem cells in Mammals - Teams

Research interest

CR1 CNRS. He obtained his PhD from the University of Lyon in 1997. After a 3-year postdoc at the University of Cambridge (UK), he joined the Savatier team in 2000. He studies LIF/STAT3 signalling in mouse and human ES cells. In collaboration with Hongwei Chen, he reprogrammed human ES cells to ground-like state of pluripotency. He also studies the role of long non-coding RNAs in ground state pluripotency.

Chen H, Aksoy I, Gonnot F, Osteil P, Aubry M, Hamela C, Rognard C, Hochard A, Voisin S, Fontaine E, Mure M, Afanassieff M, Cleroux E, Guibert S, Chen J, Vallot C, Acloque H, Genthon C, Donnadieu C, De Vos J, Sanlaville D, Guérin JF, Weber M, Stanton LW, R (2015) Reinforcement of STAT3 activity reprogrammes human embryonic stem cells to naive-like pluripotency Nat Commun. 2015 May 13;6:7095
Aksoy I, Giudice V, Delahaye E, Wianny F, Aubry M, Mure M, Chen J, Jauch R, Bogu GK, Nolden T, Himmelbauer H, Xavier Doss M, Sachinidis A, Schulz H, Hummel O, Martinelli P, Hübner N, Stanton LW, Real FX, Bourillot PY, Savatier P. (2014) Klf4 and Klf5 differentially inhibit mesoderm and endoderm differentiation in embryonic stem cells. Nat Comm, 5:3719
Coronado D, Godet M, Bourillot PY, Tapponnier Y, Bernat A, Petit M, Afanassieff M, Markossian S, Malashicheva A, Iacone R., Anastassiadis K, Savatier P (2013) A short G1 phase is an intrinsic determinant of naïve embryonic stem cell pluripotency. Stem Cell Res 10(1): 118-31 download
Wianny F, Bourillot PY, Dehay C. (2011) Embryonic stem cells in non-human primates: An overview of neural differentiation potential. Differentiation 81(3):142-52. download
Bourillot PY, Savatier P. (2010) Krüppel-like transcription factors and control of pluripotency. BMC Biol. 27(8): 125 Review. download
Bourillot PY, Aksoy I, Schreiber V, Wianny F, Schulz H, Hummel O, Hubner N, Savatier P. (2009) Novel STAT3 target genes exert distinct roles in the inhibition of mesoderm and endoderm differentiation in cooperation with nanog Stem Cell 27(8): 1760-1771 download
Schulz H et al (2009) Functional Genomics in Embryonic Stem Cells Consortium. The FunGenES database: a genomics resource for mouse embryonic stem cell differentiation. PloS One, 4(9): e6804. download
Aksoy I, Sakabedoyan C, Bourillot PY, Malashicheva AB, Mancip J, Knoblauch K, Afanassieff M, Savatier P (2007) Self-renewal of murine embryonic stem cells is supported by the serine/threonine kinases pim-1 and pim-3. Stem Cells 25(12):2996-3004 download
Storm MP, Bone HK, Beck CG, Bourillot PY, Schreiber V, Damiano R, Nelson A, Savatier P, Welham MJ (2007) Regulation of Nanog expression by phosphoinositide 3-kinase-dependent signaling in murine embryonic stem cells. J Biol Chem 282(9):6265-73. download
Bourillot PY, Garrett N, Gurdon JB (2002) A changing morphogen gradient is interpreted by continuous transduction flow. Development 129:2167-2180. download
Gurdon JB, Bourillot PY (2001) Morphogen gradient interpretation. Nature 413:797-803. download
Shimizu K, Bourillot PY, Nielsen SJ, Zorn AM, Gurdon JB. (2001) Swift is a novel BRCT domain coactivator of Smad2 in transforming growth factor beta signaling. Mol Cell Biol. 21(12):3901-12 download
Ryan K, Garrett N, Bourillot P, Stennard F, Gurdon JB. (2000) The Xenopus eomesodermin promoter and its concentration-dependent response to activin. Mech Dev. 94(1-2):133-46 download
Bourillot PY, Waltzer L, Sergeant A, Manet E. (1998) Transcriptional repression by the Epstein-Barr virus EBNA3A protein tethered to DNA does not require RBP-Jkappa. J Gen Virol. 79 ( Pt 2):363-70 download
Manet E, Bourillot PY, Waltzer L, Sergeant A. (1998) EBV genes and B cell proliferation. Crit Rev Oncol Hematol.28(2):129-37 download
Waltzer L, Bourillot PY, Sergeant A, Manet E (1995) RBP-J kappa repression activity is mediated by a co-repressor and antagonized by the Epstein-Barr virus transcription factor EBNA2. Nucleic Acids Res. 23(24):4939-45 download