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Stem-cell and Brain Research Institute
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Conference by Adrien Meguerditchian

Published on March 28, 2017

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Pierre Savatier

Position: Research Director

Company: Inserm U846

Mailing Address:
18 av du Doyen Jean Lepine

69675 - Bron Cedex - France
External Link: www.sbri.fr
E-mail: Pierre.Savatier@inserm.fr

StemGamE - Platforms
Investissements d'Avenir : Ingestem - European funded projects
Investissements d'Avenir : LabEx DEVweCAN - European funded projects
Investissements d'Avenir : LabEx CORTEX - European funded projects
Investissements d'Avenir : Cesame - Plateforme d'ingénierie cellulaire - Platforms
Pluripotent stem cells in Mammals - Teams (leader)

Research interest

DR2 INSERM, Team leader. He obtained his PhD from the University of Lyon in 1986. He joined INSERM in 2004 as an AVENIR team leader, and the same year he was awarded the “Coup d’Elan pour la recherche” from the Bettencourt Foundation. His team participates in two laboratory of excellence (LabEx): DEVweCAN and CORTEX. His is responsible for PrimaStem, a technological platform specialized in pluripotent stem cells in primates. PrimaStem participates in the "National Infrastructure for pluripotent stem cells" (INGESTEM) and the IHU-B CESAME.

Afanassieff M, Osteil P, Savatier P. (2015) Generation of embryonic stem cells in rabbits. Methods Mol Biol. 1357:49-66
Chen H, Aksoy I, Gonnot F, Osteil P, Aubry M, Hamela C, Rognard C, Hochard A, Voisin S, Fontaine E, Mure M, Afanassieff M, Cleroux E, Guibert S, Chen J, Vallot C, Acloque H, Genthon C, Donnadieu C, De Vos J, Sanlaville D, Guérin JF, Weber M, Stanton LW, R (2015) Reinforcement of STAT3 activity reprogrammes human embryonic stem cells to naive-like pluripotency Nat Commun. 2015 May 13;6:7095
Afanassieff M, Tapponnier Y, Savatier P (2014) Generation of Induced Pluripotent Stem Cells in Rabbits. Methods Mol Biol. [Epub ahead of print]
Aksoy I, Giudice V, Delahaye E, Wianny F, Aubry M, Mure M, Chen J, Jauch R, Bogu GK, Nolden T, Himmelbauer H, Xavier Doss M, Sachinidis A, Schulz H, Hummel O, Martinelli P, Hübner N, Stanton LW, Real FX, Bourillot PY, Savatier P. (2014) Klf4 and Klf5 differentially inhibit mesoderm and endoderm differentiation in embryonic stem cells. Nat Comm, 5:3719
Vezoli J, Wianny F, Dzahini K, Dolmazon V, Bernat A, Fifel K, Wilson CRE, Gronfier C, Procyk E, Cooper HM, Savatier P, Dehay C, Kennedy H (2014) Host-integration of neural precursors in parkinsonian monkeys: outcome on clinical, cognitive, circadian and DA function. Cell Symposia: Translational Neuroscience. Arlington, VA, USA. download
Schmaltz-Panneau B, Jouneau L, Osteil P, Tapponnier Y, Afanassieff M, Moraldo M, Jouneau A, Daniel N, Archilla C, Savatier P, Duranthon V (2014) Contrasting transcriptome landscapes of rabbit pluripotent stem cells in vitro and in vivo. Anim Reprod Sci, doi: 10.1016/j.anireprosci.2014.05.014
Coronado D, Godet M, Bourillot PY, Tapponnier Y, Bernat A, Petit M, Afanassieff M, Markossian S, Malashicheva A, Iacone R., Anastassiadis K, Savatier P (2013) A short G1 phase is an intrinsic determinant of naïve embryonic stem cell pluripotency. Stem Cell Res 10(1): 118-31 download
Delaspre F, Massumi M, Solé F, Soria B, Ravassard P, Savatier P, Skoudy A (2013) Directed pancreatic acinar differentiation of mouse embryonic stem cells via embryonic signalling molecules and exocrine transcription Factorsrs involved in pancreatic development PloS One. 8(1):e54243 download
Osteil P, Tapponnier Y, Markossian S, Godet M, Schmaltz-Panneau B, Jouneau L, Cabau C, Joly T, Blachère T, Gozca E, Bernat A, Yerle M, Acloque H, Hidot S, Bözse Z, Duranthon V, Savatier P, Afanassieff M (2013) Induced pluripotent stem cells derived from rabbits exhibit some characteristics of naïve pluripotency Biology Open 2:613-628 download
Tancos Z, Nemes C, Polgar Z, Gocza E, Daniel N, Stout TA, Maraghechi P, Pirity MK, Osteil P, Tapponnier Y, Markossian S, M. Godet, M. Afanassieff, Bosze Z, Duranthon V, Savatier P, Dinnyes A. (2012) Generation of rabbit pluripotent stem cell lines. Theriogenology 78:1774-86. download
Dolmazon V, Alenina N, Markossian S, Mancip J, van de Vrede Y, Fontaine E, Dehay C, Kennedy H, Bader M, Savatier P, Bernat A (2011) Forced expression of Lmx1b enhances differentiation of mouse ES cells into serotonergic neurons. Stem Cells Dev, 2011, 20:301-311
Bourillot PY, Savatier P. (2010) Krüppel-like transcription factors and control of pluripotency. BMC Biol. 27(8): 125 Review. download
Niu Y, Yu Y, Bernat A, Yang S, He X, Guo X, Chen D, Chen Y, Ji S, Si W, Tan T, Wei Q, Wang H, Shi L, Afanassieff M, *Savatier P, *Zhou Q, *Ji W (2010) Transgenic rhesus monkeys produced by gene transfer into early cleavage stage embryos using a simian immunodeficiency virus-based vector. Proc Natl Acad Sci USA, 107:17663-7
Bourillot PY, Aksoy I, Schreiber V, Wianny F, Schulz H, Hummel O, Hubner N, Savatier P. (2009) Novel STAT3 target genes exert distinct roles in the inhibition of mesoderm and endoderm differentiation in cooperation with nanog Stem Cell 27(8): 1760-1771 download
Schulz H et al (2009) Functional Genomics in Embryonic Stem Cells Consortium. The FunGenES database: a genomics resource for mouse embryonic stem cell differentiation. PloS One, 4(9): e6804. download
Marchand M, Schröder I, Markossian S, Skoudy A. Nègre D. Cosset FL, Real FX, Wobus AM, Savatier P (2009) Mouse ES cells overexpressing the transcription factor NeuroD1 show increased differentiation towards endocrine lineages Int. J. Dev. Biol. 53:569-578. download
Rovira M, Delaspre F, Massumi M, Serra SA, Valverde MA, Lloreta J, Dufresne M, Payré B, Konieczny SF, Savatier P, Real FX, Skoudy A. (2008) Murine Embryonic Stem Cell-Derived Pancreatic Acinar Cells Recapitulate Features of Early Pancreatic Differentiation. Gastroenterology. 25
Aksoy I, Sakabedoyan C, Bourillot PY, Malashicheva AB, Mancip J, Knoblauch K, Afanassieff M, Savatier P (2007) Self-renewal of murine embryonic stem cells is supported by the serine/threonine kinases pim-1 and pim-3. Stem Cells 25(12):2996-3004 download
Storm MP, Bone HK, Beck CG, Bourillot PY, Schreiber V, Damiano R, Nelson A, Savatier P, Welham MJ (2007) Regulation of Nanog expression by phosphoinositide 3-kinase-dependent signaling in murine embryonic stem cells. J Biol Chem 282(9):6265-73. download
Rovira M, Jané-Valbuena J, Marchand M, Savatier P, Real FX, Skoudy A. (2007) Viral-mediated coexpression of Pdx1 and p48 regulates exocrine pancreatic differentiation in mouse ES cells. Cloning Stem Cells.9(3):327-38 download
Savatier P. (2007) What's new on ES cells? Med Sci (Paris). 23(4):358-9 download
Lukaszewicz A, Savatier P, Cortay V, Giroud P, Huissoud C, Berland M, Kennedy H, Dehay C (2005) G1 phase regulation, Area-Specific cell cycle control, and Cytoarchitectonics in the Primate Cortex. Neuron, 2005, 47:353-364 download
Moriscot C, de Fraipont F, Richard MJ, Marchand M, Savatier P, Bosco D, Favrot M, Benhamou PY. (2005) Human bone marrow mesenchymal stem cells can express insulin and key transcription factors of the endocrine pancreas developmental pathway upon genetic and/or microenvironmental manipulation in vitro. Stem Cells 23(4):594-603. download
Skoudy A, Rovira M, Savatier P, Martin F, León-Quinto T, Soria B, Real FX. (2004) Transforming growth factor (TGF)beta, fibroblast growth factor (FGF) and retinoid signalling pathways promote pancreatic exocrine gene expression in mouse embryonic stem cells. Biochem J 379(Pt 3):749-56. download
Savatier, P.; Malashicheva, A. (2004) Cell-cycle control in embryonic stem cells Handbook of stem cells Vol: 2: Embryonic Stem Cells download
Fluckiger AC, Dehay C, Savatier P. (2003) Embryonic stem cells and cell replacement therapies in the nervous system Med Sci (Paris). 19(6-7):699-708 download
Lukaszewicz A, Savatier P, Cortay V, Kennedy H, Dehay C (2002) Contrasting Effects of Basic Fibroblast Growth Factor and Neurotrophin 3 on Cell Cycle Kinetics of Mouse Cortical Stem Cells. J Neurosci, 2002, 12(5) : 6610-6622 download
Jirmanova L, Afanassieff M, Gobert-Gosse S, Markossian S, Savatier P (2002) Differential contributions of ERK and PI3-kinase to the regulation of cyclin D1 expression and to the control of the G1/S transition in mouse embryonic stem cells. Oncogene 21:5515-28 download
Burdon T, Smith AG, Savatier P (2002) Signalling, cell cycle and pluripotency in embryonic stem cells. Trends Cell Biol 12:432-8 download
Savatier P, Lapillonne H, Jirmanova L, Vitelli L, Samarut J (2002) Analysis of the cell cycle in mouse embryonic stem cells. Methods Mol Biol.185:27-33 download
Savatier P, Afanassieff M (2002) Cell cycle control and self-renewal of embryonic stem cells J Soc Biol 196(1): 117-23.
Dehay C, Savatier P, Cortay V, Kennedy H (2001) Cell-cycle kinetics of neocortical precursors are influenced by embryonic thalamic axons. J Neurosci, 2001, 21:201-214 download
Vallier L, Mancip J, Markossian S, Lukaszewicz A, Dehay C, Metzger D, Chambon P, Samarut J, Savatier P (2001) An efficient system for conditional gene expression in embryonic stem cells and their in vitro and in vivo differentiated derivatives. Proc Nat Acad Sci USA 98:2467-2472 download
Goumans MJ, Ward-Van O, Wianny F, Savatier P, Zwijsen A, Mummery CL (1998) Mouse embryonic stem cells with aberrant transforming growth factor beta signalling exhibit impaired differentiation in vitro and in vivo. Differentiation 63(3):101-13 download
Wianny F, Real FX, Mummery CL, Van Rooijen M, Lahti J, Samarut J, Savatier P (1998) G1 phase regulation, Cyclin D1, Cyclin D2 and Cyclin D3: up-regulation at gastrulation and dynamic expression during neurolation. Dev Dyn 212:49-62 download
Goumans MJ, Ward-Van O, Wianny F, Savatier P, Zwijsen A, Mummery CL (1998) Embryonic stem cells with aberrant TGFBeta signalling exhibit impaired differentiation in vitro and in vivo. Differentiation 63(3):101-13 download
Kennedy H, Dehay C, Savatier P. (1998) Modulation du cycle cellulaire et spécification des aires du neocortex Arch Physiol Biochem 106:1-5
Chassande O, Fraichard A, Gauthier K, Flamant F, Legrand C, Savatier P, Laudet V, Samarut J. (1997) Identification of transcripts initiated from an internal promoter in the c-erbA alpha locus that encode inhibitors of retinoic acid receptor-alpha and triiodothyronine receptor activities. Mol Endocrinol. 11(9):1278-90 download
Savatier P, Lapillonne H, van Grunsven LA, Rudkin BB, Samarut J (1996) Withdrawal of differentiation inhibitory activity/leukemia inhibitory factor up-regulates D-type cyclins and cyclin-dependent kinase inhibitors in mouse embryonic stem cells. Oncogene 12:309-322 download
Rouault JP, Falette N, Guéhenneux F, Guillot C, Rimokh R, Wang Q, Berthet C, Moyret-Lalle C, Savatier P, Pain B, Shaw P, Berger R, Samarut J, Magaud JP, Ozturk M, Samarut C, Puisieux A. (1996) Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway. Nat Genet. 14(4):482-6 download
van Grunsven LA, Billon N, Savatier P, Thomas A, Urdiales JL, Rudkin BB. (1996) Effect of nerve growth factor on the expression of cell cycle regulatory proteins in PC12 cells: dissection of the neurotrophic response from the anti-mitogenic response. Oncogene. 12(6):1347-56 download
Fraichard A, Chassande O, Bilbault G, Dehay C, Savatier P, Samarut J (1995) In vitro differentiation of ES cells into glial cells and functional neurons. J Cell Sci 108:3181-8 download
Cosset FL, Legras C, Chebloune Y, Savatier P, Thoraval P, Thomas JL, Samarut J, Nigon VM, Verdier G. (1990) A new avian leukosis virus-based packaging cell line that uses two separate transcomplementing helper genomes. J Virol. 64(3):1070-8 download
Savatier P, Morgenstern J, Beddington RS. (1990) Permissiveness to murine leukemia, virus expression during preimplantation and early postimplantation mouse development. Development. 109(3):655-65 download
Benchaib M, Mallet F, Thoraval P, Savatier P, Xiao JH, Verdier G, Samarut J, Nigon V. (1989) Avian retroviral vectors derived from avian defective leukemia virus: role of the translational context of the inserted gene on efficiency of the vectors. Virology. 169(1):15-26 download
Savatier P, Bagnis C, Thoraval P, Poncet D, Belakebi M, Mallet F, Legras C, Cosset FL, Thomas JL, Chebloune Y, et al. (1989) Generation of a helper cell line for packaging avian leukosis virus-based vectors. J Virol. 63(2):513-22 download
Savatier P, Trabuchet G, Chebloune Y, Faure C, Verdier G, Nigon VM. (1987) Nucleotide sequence of the beta-globin genes in gorilla and macaque: the origin of nucleotide polymorphisms in human. J Mol Evol.24(4):309-18 download
Savatier P, Trabuchet G, Chebloune Y, Faure C, Verdier G, Nigon VM. (1987) Nucleotide sequence of the delta-beta-globin intergenic segment in the macaque: structure and evolutionary rates in higher primates. J Mol Evol.24(4):297-308 download
Thoraval P, Savatier P, Xiao JH, Mallet F, Samarut J, Verdier G, Nigon V. (1987) Partial nucleotide sequence of the avian erythroblastosis virus (AEV ES4). Nucleic Acids Res. 15(22):9612 download
Trabuchet G, Chebloune Y, Savatier P, Lachuer J, Faure C, Verdier G, Nigon VM. (1987) Recent insertion of an Alu sequence in the beta-globin gene cluster of the gorilla. J Mol Evol. 25(4):288-91 download
Savatier P, Trabuchet G, Faure C, Chebloune Y, Gouy M, Verdier G, Nigon VM (1985) Evolution of the primate beta-globin gene region. High rate of variation in CpG dinucleotides and in short repeated sequences between man and chimpanzee. J Mol Biol. 182(1):21-9 download