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Stem-cell and Brain Research Institute
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Conference by Adrien Meguerditchian

Published on March 28, 2017

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Pierre Misery

Position: Research Engineer

Company: Inserm u846

Mailing Address:
18 avenue de Doyen Jean LÚpine

69675 - Bron Cedex - France
External Link: www.sbri.fr
E-mail: Pierre.Misery@inserm.fr

Cortical architecture, coding and perception - Teams

Research interest

I am working on the cortico-cortical connectivity of the macaque. We use retrograde tracers to examine topography of interareal connectivity. To do this, we inject tracers in the brain of macaque using MRI guided technology (Brain Sight). We carry out histological processing on the brain so as to accurately allocate labelled neurons to particular cortical areas.
An important aspect of the analysis of the material is the recording of the XY coordinates of very large numbers of neurons using a digitalised image system running on Explora Nova software (Mercator). With Explora Nova we are currently developing two major approaches to improving our work. Firstly, a fully automatic dedicated microscopy station able to chart fluorescent cells in individual cortical layers and areas. This will make it possible to reduce processing time by up to 80% and will make it possible to greatly extend the scope of our enquiry.  Secondly, the ability to construct 3 and 2D reconstructions of cortical labelling. This will make it possible to obtain accurate data on individual neuron pathway length, important for our on going modelling of the networks of the cerebral cortex.

Markov NT, Ercsey-Ravasz MM, Ribeiro Gomes AR, Lamy C, Magrou L, Vezoli J, Misery P, Falchier A, Quilodran R, Gariel MA, Sallet J, Gamanut R, Huissoud C, Clavagnier S, Giroud P, Sappey-Marinier D, Barone P et al (2014) A weighted and directed interareal connectivity matrix for macaque cerebral cortex. Cereb Cortex, 2014, 24(1):17-36 download
Markov NT, Vezoli J, Chameau P, Falchier A, Quilodran R, Huissoud C, Lamy C, Misery P, Giroud P, Ullman S, Barone P, Dehay C, Knoblauch K, Kennedy H. (2014) The anatomy of hierarchy: Feedforward and feedback pathways in macaque visual cortex. J Comp Neurol, 2014, 522(1):225-259 download
Markov N.T., Ercsey-Ravasz M., Lamy C., Ribeiro-Gomes A.R., Magrou L., Misery P., Giroud P. Barone P., Dehay C., Toroczkai Z., Knoblauch, K., Van Essen D.C., Kennedy H. (2013) The role of long-range connections on the specificity of the macaque interareal cortical network. Proc Nat Acad Sci USA, 2013, 110, 5187-5192 download
Markov NT, Misery P, Falchier A, Lamy C, Vezoli J, Quilodran R, Gariel MA, Giroud P, Ercsey-Ravasz M, Pilaz LJ, Huissoud C, Barone P, Dehay C, Toroczkai Z, Van Essen DC, Kennedy H, Knoblauch K (2011) Weight Consistency Specifies Regularities of Macaque Cortical Networks. Cereb Cortex. 2011, 21:1254-1272 download
Mithieux G, Misery P, Magnan C, Pillot B, Gautier-Stein A, Bernard C, Rajas F, Zitoun C (2005) Portal sensing of intestinal gluconeogenesis is a mechanistic link in the diminution of food intake induced by diet protein Cell Metab 2(5):321-329 download