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Semaine du Cerveau

Published on March 13, 2017

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Nasser Haddjeri


Company: Inserm U846

Mailing Address:
Université Claude Bernard
8, avenue Rockfeller
69373 - Lyon Cedex - France
External Link:
Phone: 04 26 68 82 15

Chronobiology and affective disorders - Teams (leader)

Research interest

Since 20 years, my research focuses on the neurobiology of mood disorders and their responses to antidepressant treatments. A main goal is to understand the neural bases associated to the antidepressant responses in order to develop novel therapeutics for affective disorders. My work particularly focus on gaining a clearer understanding of the physiology and pharmacology of brain monoamine neurotransmitters and how these neurotransmitter systems are affected by established and novel antidepressant strategies. To this end, I utilize a wide range of techniques including in vivo electrophysiology, behavioural analysis and immunocytochemistry.

Etiévant A, Lucas G, Dkhissi-Benyahya O, Haddjeri N (2016) The Role of Astroglia in the Antidepressant Action of Deep Brain Stimulation Front Cell Neurosci. 2016 9:509.
Bétry C, Overstreet D, Haddjeri N, Pehrson AL, Bundgaard C, Sanchez C, Mřrk A (2015) A 5-HT3 receptor antagonist potentiates the behavioral, neurochemical and electrophysiological actions of an SSRI antidepressant Pharmacol Biochem Behav. 2015 Apr;131:136-42
A. Etiévant, C. Oosterhof, C. Bétry, E. Abrial, M. Novo-Perez, R. Rovera, H. Scarna, C. Devader, J. Mazella, G. Wegener, C. Sánchez, O. Dkhissi-Benyahya, C. Gronfier, V. Coizet, J.M. Beaulieu, P. Blier, G. Lucas, N. Haddjeri (2015) Astroglial control of the antidepressant-like effects of prefrontal cortex deep brain stimulation EbioMedecine. 2(8):896-906
Bétry C, Etiévant A, Pehrson A, Sánchez C, Haddjeri N (2015) Effect of the multimodal acting antidepressant vortioxetine on rat hippocampal plasticity and recognition memory Prog Neuropsychopharmacol Biol Psychiatry. 2015 Apr 3;58:38-46
Westrich L, Haddjeri N, Dkhissi-Benyahya O, Sánchez C (2015) Involvement of 5-HT₇ receptors in vortioxetine's modulation of circadian rhythms and episodic memory in rodents Neuropharmacology. 2015; 89:382-90
Abrial E, Bétourné E, Etiévant A, Lucas G, Scarna H, Lambás-Seńas L, Haddjeri N (2014) Protein kinase C inhibition rescues manic-like behaviors and hippocampal cell proliferation deficits in the sleep deprivation model of mania. Int J Neuropsychopharmacol, in press.
Abrial E, Etiévant A, Bétry C, Scarna H, Lucas G, Haddjeri N, Lambás-Seńas L (2013) Protein kinase C regulates mood-related behaviors and adult hippocampal cell proliferation in rats. Prog Neuro-Psychopharmacol Biol Psychiatry, 43(3): 40–48
The rapid recovery of 5-HT cell firing induced by the antidepressant vortioxetine involves 5-HT3 receptor antagonism. (2013) Betry C, Etievant A, Ebert B, Pehrson A, Sánchez C, Haddjeri N International Journal of Neuropsychopharmacology. 16(5):1115-1127.
Betry C, Etievant A, Ebert B, Pehrson A, Sánchez C, Haddjeri N (2013) The rapid recovery of 5-HT cell firing induced by the antidepressant vortioxetine involves 5-HT3 receptor antagonism. International Journal of Neuropsychopharmacology. 16(5):1115-1127.
Etievant A, Lambas-Senas L, Scarna H, Lucas G, Haddjeri N (2013) Astrocyte and gliotransmitters: New players in the treatment of major depression Current Drug Targets. 14: 1295-1307
Mnie Fiali O, Faure C, Lambas-Senas L, El Mansari M, Belblidia H, Gondard E, Etievant A, Scarna H, Didier A, Berod A, Blier P, Haddjeri N (2011) Pharmacological blockade of 5-HT7 receptors induces a fast antidepressant-like response. Neuropsychopharmacology. 36(6):1275-88.
Serrano A., Haddjeri N., Lacaille J-C., Robitaille R. (2006) Network interactions between GABA interneurons and glial cells in hippocampal heterosynaptic depression. J Neurosci. 26(20): 5370-5380.
El Mansari M., Sanchez C, Chouvet G., Renaud B. and Haddjeri N. (2005) Effects of acute and long-term administration of escitalopram and citalopram on serotonin neurotransmission: an in vivo electrophysiological study in rat brain. Neuropsychopharmacology, 30(7): 1269-1277.
Haddjeri N., Lavoie N., Blier P. (2004) Noradrenergic modulation of raphe 5-HT neuronal firing and hippocampal 5-HT release in vivo in the rat brain. Neuropsychopharmacology. Neuropsychopharmacology. 29(10):1800-1806.
Haddjeri N., Blier P. (2001) Sustained blockade of NK1 receptors enhances serotonin neurotransmission. Biological Psychiatry. 53(3): 191-199.
Haddjeri N., Szabo S.T., de Montigny C., Blier P. (2000) Increased tonic activation of rat forebrain 5-HT1A receptors by lithium addition to antidepressant treatments. Neuropsychopharmacology. 22(4): 346-356
Haddjeri N., de Montigny C., Blier P. (1999) Modulation of the firing activity of dorsal raphe 5-HT neurons and locus coeruleus NA neurons by (±)pindolol Biological Psychiatry. 45(9): 1163-1169.
Haddjeri N., Blier P., de Montigny C (1998) Antidepressant treatments tonically activate forebrain 5-HT1A receptors. J Neurosci, 18(23): 10150-10156.