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Conference by Adrien Meguerditchian

Published on March 28, 2017

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Marielle Afanassieff

Position: Research Fellow


Mailing Address:
18 avenue du Doyen Jean Lépine

69495 - Bron Cedex - France
External Link:

StemGamE - Platforms (leader)

Research interest

CR1 INRA. She obtained her PhD from the University of Lyon in 1991. After a postdoc at the "City of Hope" Hospital in California, she joined the Savatier team in 2004. She now studies the transcriptome of the rabbit pre-implantation, and engineers ES cell lines suitable for the generation of somatic and germline chimaeras in rabbits.

Afanassieff M, Osteil P, Savatier P. (2015) Generation of embryonic stem cells in rabbits. Methods Mol Biol. 1357:49-66
Chen H, Aksoy I, Gonnot F, Osteil P, Aubry M, Hamela C, Rognard C, Hochard A, Voisin S, Fontaine E, Mure M, Afanassieff M, Cleroux E, Guibert S, Chen J, Vallot C, Acloque H, Genthon C, Donnadieu C, De Vos J, Sanlaville D, Guérin JF, Weber M, Stanton LW, R (2015) Reinforcement of STAT3 activity reprogrammes human embryonic stem cells to naive-like pluripotency Nat Commun. 2015 May 13;6:7095
Congras A, Barasc H, Delcros C, Vignoles F, Pinton A, Canale-Tabet K, Feraud O, Turhan A, Afanassieff M, Yerle-Bouissou M, Acloque H (2014) 330 derivation of porcine induced pluripotent stem cells from fibroblasts of a translocated azoospermic boar. Reprod Fertil Dev. 27(1):254.
Afanassieff M, Tapponnier Y, Savatier P (2014) Generation of Induced Pluripotent Stem Cells in Rabbits. Methods Mol Biol. [Epub ahead of print]
Schmaltz-Panneau B, Jouneau L, Osteil P, Tapponnier Y, Afanassieff M, Moraldo M, Jouneau A, Daniel N, Archilla C, Savatier P, Duranthon V (2014) Contrasting transcriptome landscapes of rabbit pluripotent stem cells in vitro and in vivo. Anim Reprod Sci, doi: 10.1016/j.anireprosci.2014.05.014
Coronado D, Godet M, Bourillot PY, Tapponnier Y, Bernat A, Petit M, Afanassieff M, Markossian S, Malashicheva A, Iacone R., Anastassiadis K, Savatier P (2013) A short G1 phase is an intrinsic determinant of naïve embryonic stem cell pluripotency. Stem Cell Res 10(1): 118-31 download
Osteil P, Tapponnier Y, Markossian S, Godet M, Schmaltz-Panneau B, Jouneau L, Cabau C, Joly T, Blachère T, Gozca E, Bernat A, Yerle M, Acloque H, Hidot S, Bözse Z, Duranthon V, Savatier P, Afanassieff M (2013) Induced pluripotent stem cells derived from rabbits exhibit some characteristics of naïve pluripotency Biology Open 2:613-628 download
Betizeau M, Cortay V, Patti D, Pfister S, Gautier E, Bellemin-Ménard A, Afanassieff M, Huissoud C, Douglas RJ, Kennedy K, Dehay C (2013) Precursor Diversity and Complexity of Lineage Relationships in the Outer Subventricular Zone of the Primate. Neuron 80 :442-457 download
Tancos Z, Nemes C, Polgar Z, Gocza E, Daniel N, Stout TA, Maraghechi P, Pirity MK, Osteil P, Tapponnier Y, Markossian S, M. Godet, M. Afanassieff, Bosze Z, Duranthon V, Savatier P, Dinnyes A. (2012) Generation of rabbit pluripotent stem cell lines. Theriogenology 78:1774-86. download
Niu Y, Yu Y, Bernat A, Yang S, He X, Guo X, Chen D, Chen Y, Ji S, Si W, Tan T, Wei Q, Wang H, Shi L, Afanassieff M, *Savatier P, *Zhou Q, *Ji W (2010) Transgenic rhesus monkeys produced by gene transfer into early cleavage stage embryos using a simian immunodeficiency virus-based vector. Proc Natl Acad Sci USA, 107:17663-7
Aksoy I, Sakabedoyan C, Bourillot PY, Malashicheva AB, Mancip J, Knoblauch K, Afanassieff M, Savatier P (2007) Self-renewal of murine embryonic stem cells is supported by the serine/threonine kinases pim-1 and pim-3. Stem Cells 25(12):2996-3004 download
Thoraval P, Afanassieff M, Bouret D, Luneau G, Esnault E, Goto RM, Chaussé AM, Zoorob R, Soubieux D, Miller MM, Dambrine G. (2003) Role of nonclassical class I genes of the chicken major histocompatibility complex Rfp-Y locus in transplantation immunity. Immunogenetics. 55(9):647-51. Epub 2003 Nov 4 download
Jirmanova L, Afanassieff M, Gobert-Gosse S, Markossian S, Savatier P (2002) Differential contributions of ERK and PI3-kinase to the regulation of cyclin D1 expression and to the control of the G1/S transition in mouse embryonic stem cells. Oncogene 21:5515-28 download
Goto RM, Afanassieff M, Ha J, Iglesias GM, Ewald SJ, Briles WE, Miller MM. (2002) Single-strand conformation polymorphism (SSCP) assays for major histocompatibility complex B genotyping in chickens. Poult Sci. 81(12):1832-41 download
Le Rouzic E, Thoraval P, Afanassieff M, Cherel Y, Dambrine G, Perbal B. (2002) Alterations of the MDV oncogenic regions in an MDV transformed lymphoblastoid cell line. Mol Pathol. 55(4):262-72 download
Savatier P, Afanassieff M (2002) Cell cycle control and self-renewal of embryonic stem cells J Soc Biol 196(1): 117-23.
Afanassieff M, Goto RM, Ha J, Sherman MA, Zhong L, Auffray C, Coudert F, Zoorob R, Miller MM (2001) At least one class I gene in restriction fragment pattern-Y (Rfp-Y), the second MHC gene cluster in the chicken, is transcribed, polymorphic, and shows divergent specialization in antigen binding region. J Immunol 166:3324-33. download
Juul-Madsen HR, Dalgaard TS, Afanassieff M. (2000) Molecular characterization of major and minor MHC class I and II genes in B21-like haplotypes in chickens. Anim Genet.31(4):252-61 download
Jullien D, Afanassieff M, Claudy A, Nicolas JF, Kaiserlian D (1999) CD1 : une nouvelle famille de molécules présentatrices d'antigènes aux caractéristiques singulières MS. Médecine sciences 15(1): 7-14 download
Afanassieff M, Dambrine G, Ronfort C, Lasserre F, Coudert F, Verdier G. (1996) Intratesticular inoculation of avian leukosis virus (ALV) in chickens--production of neutralizing antibodies and lack of virus shedding into semen. Avian Dis 40(4):841-52 download
Cere N, Humbert JF, Licois D, Corvione M, Afanassieff M, Chanteloup N (1996) A new approach for the identification and the diagnosis of Eimeria media parasite of the rabbit Exp Parasitol 82(2): 132-8 download
Thoraval P, Afanassieff M, Cosset FL, Lasserre F, Verdier G, Coudert F, Dambrine G. (1995) Germline transmission of exogenous genes in chickens using helper-free ecotropic avian leukosis virus-based vectors. Transgenic Res. 4(6):369-77 download
Thomas JL, Afanassieff M, Cosset FL, Molina RM, Ronfort C, Drynda A, Legras C, Chebloune Y, Nigon VM, Verdier G. (1992) In situ expression of helper-free avian leukosis virus (ALV)-based retrovirus vectors in early chick embryos. Int J Dev Biol.36(2):215-27 download
Ronfort C, Afanassieff M, Chebloune Y, Dambrine G, Nigon VM, Verdier G. (1991) Identification and structure analysis of endogenous proviral sequences in a Brown Leghorn chicken strain. Poult Sci.70(10):2161-75 download