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Semaine du Cerveau

Published on March 13, 2017



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Irène Aksoy-Marcy

Position: Research Scientist

Company: Inserm U846


Mailing Address:
18, avenue Doyen Lépine

69500 - Bron - France
External Link:
E-mail: irene.aksoy@inserm.fr
Phone: +33 4 72 91 34 64
Fax:


Group(s):
Pluripotent stem cells in Mammals - Teams

Research interest

Postdoc. She obtained her PhD from the University of Lyon in 2008. After a 5-year postdoc at the Genome Institute of Singapore, where she studied different aspects of somatic cell reprogramming, she joined the Savatier team in 2013 to work on pluripotency in non-human primates. She studies the transcriptome of the macaque pre-implantation, and reprograms ES cell lines suitable for the generation of somatic chimaeras in the rhesus macaque.

Publications
Chen H, Aksoy I, Gonnot F, Osteil P, Aubry M, Hamela C, Rognard C, Hochard A, Voisin S, Fontaine E, Mure M, Afanassieff M, Cleroux E, Guibert S, Chen J, Vallot C, Acloque H, Genthon C, Donnadieu C, De Vos J, Sanlaville D, Guérin JF, Weber M, Stanton LW, R (2015) Reinforcement of STAT3 activity reprogrammes human embryonic stem cells to naive-like pluripotency Nat Commun. 2015 May 13;6:7095
Aksoy I, Giudice V, Delahaye E, Wianny F, Aubry M, Mure M, Chen J, Jauch R, Bogu GK, Nolden T, Himmelbauer H, Xavier Doss M, Sachinidis A, Schulz H, Hummel O, Martinelli P, Hübner N, Stanton LW, Real FX, Bourillot PY, Savatier P. (2014) Klf4 and Klf5 differentially inhibit mesoderm and endoderm differentiation in embryonic stem cells. Nat Comm, 5:3719
Utami KH, Winata CL, Hillmer AM, Aksoy I, Long HT, Liany H, Chew EG, Mathavan S, Tay SK, Korzh V, Sarda P, Davila S, Cacheux V (2014) Impaired development of neural-crest cell-derived organs and intellectual disability caused by MED13L haploinsufficiency. Hum Mutat. 35(11):1311
Utami KH, Hillmer AM, Aksoy I, Chew EG, Teo AS, Zhang Z, Lee CW, Chen PJ, Seng CC, Ariyaratne PN, Rouam SL, Soo LS, Yousoof S, Prokudin I, Peters G, Collins F, Wilson M, Kakakios A, Haddad G, Menuet A, Perche O, Tay SK, Sung KW, Ruan X, Ruan Y et al (2014) Detection of chromosomal breakpoints in patients with developmental delay and speech disorders. PLoS One 9(6):e90852
Aksoy I, Jauch R, Eras V, Chng WB, Chen J, Divakar U, Ng CK, Kolatkar PR, Stanton LW (2013) Sox transcription factors require selective interactions with Oct4 and specific transactivation functions to mediate reprogramming. Stem Cells 31(12):2632.
Aksoy I, Stanton LW (2013) Pluripotency-regulating networks provide basis for reprogramming. Curr Mol Med. 13(5):695
Aksoy I, Jauch R, Chen J, Dyla M, Divakar U, Bogu GK, Teo R, Leng Ng CK, Herath W, Lili S, Hutchins AP, Robson P, Kolatkar PR, Stanton LW (2013) Oct4 switches partnering from Sox2 to Sox17 to reinterpret the enhancer code and specify endoderm. EMBO J. 32(7):938.
Jauch R, Aksoy I, Hutchins AP, Ng CK, Tian XF, Chen J, Palasingam P, Robson P, Stanton LW, Kolatkar PR (2011) Conversion of Sox17 into a pluripotency reprogramming factor by reengineering its association with Oct4 on DNA Stem Cells 29(6):940
Bourillot PY, Aksoy I, Schreiber V, Wianny F, Schulz H, Hummel O, Hubner N, Savatier P. (2009) Novel STAT3 target genes exert distinct roles in the inhibition of mesoderm and endoderm differentiation in cooperation with nanog Stem Cell 27(8): 1760-1771 download
Schulz H et al (2009) Functional Genomics in Embryonic Stem Cells Consortium. The FunGenES database: a genomics resource for mouse embryonic stem cell differentiation. PloS One, 4(9): e6804. download
Irène Aksoy-Marcy (2008) Identification et caractérisation fonctionnelle des gènes cibles de la voie LIF/STAT3 impliqués dans le contrôle de l’autorenouvellement des cellules souches embryonnaires. Thèse download
Aksoy I, Sakabedoyan C, Bourillot PY, Malashicheva AB, Mancip J, Knoblauch K, Afanassieff M, Savatier P (2007) Self-renewal of murine embryonic stem cells is supported by the serine/threonine kinases pim-1 and pim-3. Stem Cells 25(12):2996-3004 download



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