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Stem-cell and Brain Research Institute
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Conference by Adrien Meguerditchian

Published on March 28, 2017

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Dr. Howard Cooper

Position: Director of Research, DR1

Company: INSERM U846

Mailing Address:
18 avenue du Doyen Jean Lépine

69675 - Bron Cedex - France
External Link: www.sbri.fr
E-mail: Howard.Cooper@inserm.fr

- (leader)
Cell replacement therapy for early Parkinson’s disease - Transversal projects
Chronobiology - Platforms
Chronobiology and affective disorders - Teams (leader)

Personnal pages
Sleep Research in Africa: from basic neuroscience and clinical investigations to health management in developing countries

Research interest

The research aims of Neurobiological Rhythms and Sleep are focused on the molecular, cellular and behavioral mechanisms of the circadian timing system and the consequences of aging and neurodegenerative disease.
Our approaches strive to understand the mechanisms of synchronization of circadian rhythms by lignt, the molecular and physiological mechanisms of the endogenous circadian oscillators, and the regulation of output behavioral and physiological rhythms. The coding of photic information by retinal photoreceptors (rods, cones, melanopsin ganglion cells) are studied using in vivo electrophysiological recording techniques in anaesthetised and awake, freely moving animals. The effects of light (intensity, duration, spectrum) on SCN neuronal activity and on clock gene expression are also assayed using quantitative RT-PCR and microarray analysis. In order to understand the consequences of chronobiological disorders, another line of research involves investigation of the mechanisms of synchronisation of central and peripheral oscillators, including the expression of clock genes and rhythmically expressed clock controlled genes in the brain and in different body tissues. Pathological models studied include ocular diseases and Parkinson's disease in rodents and aging in a prosimian primate.
In humans, circadian photoreception and entrainment of the circadian timing system as well as chronobiological disorders related to ocular pathologies, aging and neurodegenerative diseases are studied in the framework of a European integrated project EUClock in our clinically based Platform for Research on Human Chronobiology.
In order to bridge the gap between cellular-molecular studies in rodent models and clinical studies in humans, the non-human primate is used to study the circadian timing system and sleep wake cycle and, in the framework of the laboratory transverse project, the chronobiological consequences of Parkinson's Disease.


Raymond P. Najjar; Petteri Teikari; Pierre-Loïc Cornut; Kenneth Knoblauch; Howard M. Cooper; Claude Gronfier (2016) Heterochromatic Flicker Photometry for Objective Lens Density Quantification Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1063-1071. doi:10.1167/iovs.15-18642
Najjar RP, Chiquet C, Teikari P, Cornut PL, Claustrat B, Denis P, Cooper HM, Gronfier C (2014) Aging of Non-Visual Spectral Sensitivity to Light in Humans: Compensatory Mechanisms? Plos One, 9(1): e85837 download
Fifel K, Vezoli J, Dzahini K, Claustrat B, Leviel V, Kennedy H, Procyk E, Dkhissi-Benyahya O, Gronfier C, Cooper HM (2014) Alteration of daily and circadian rhytms following dopamine depletion in MPTP treated Non-Human Primates. PLoS One, 2014, 9(1):e86240
Chellappaa SL, Lya JQM, Meyera C, Balteaua E, Degueldrea C, Luxena A, Phillipsa C, Cooper HM, Vandewallea G (2014) Photic memory for executive brain responses PNAS, 111(16): 6087-91
Vezoli J, Wianny F, Dzahini K, Dolmazon V, Bernat A, Fifel K, Wilson CRE, Gronfier C, Procyk E, Cooper HM, Savatier P, Dehay C, Kennedy H (2014) Host-integration of neural precursors in parkinsonian monkeys: outcome on clinical, cognitive, circadian and DA function. Cell Symposia: Translational Neuroscience. Arlington, VA, USA. download
Vezoli J, Dzahini K, Costes N, Wilson CR, Fifel K, Cooper HM, Kennedy H, Procyk E (2014) Increased DAT binding in the early stage of the dopaminergic lesion: a longitudinal [11C]PE2I binding study in the MPTP-monkey. Neuroimage 102:249-261
Lahouaoui H, Coutanson C, Cooper HM, Bennis M, Dkhissi-Benyahya O (2014) Clock genes and behavioral responses to light are altered in a mouse model of diabetic retinopathy. PLoS One 9(7):e101584
Dkhissi-Benyahya O, Coutanson C, Knoblauch K, Lahouaoui H, Leviel V, Rey C, Bennis M, Cooper HM. (2013) The absence of melanopsin alters retinal clock function and dopamine regulation by light. Cell Mol Life Sci. 3435-3447
Fifel K, Dkhissi-Benyahya O, Cooper HM (2013) Lack of long term changes in circadian, motor and cognitive functions in acute and chronic MPTP mouse models of Parkinson’s disease. Chronobiol Int, 30(6): 741–755
Teikari P, Najjar R P, Malkki H, Knoblauch K, Dumortier D, Gronfier C, Cooper HM. (2012) An inexpensive Arduino-based LED stimulator system for vision research. Journal of Neuroscience Methods 211, 227–236 download
Teikari P, Najjar RP, Malkki H, Knoblauch K, Dumortier D, Cornut PL, Denis P, Cooper HM, Gronfier C (2012) Refined flicker photometry technique to measure ocular lens density. Journal of the Optical Society of America A, 29, 2469–2478 download
Daneault V, Vandewalle G, Hébert M, Teikari P, Mure LS, Doyon J, Gronfier C, Cooper HM, Dumont M, Carrier J (2012) Does pupil constriction under blue and green monochromatic light exposure change with age? J Biol Rhythms, 27(3):257-64.
Vezoli J, Fifel K, Leviel V, Dehay C, Kennedy H, Cooper HM, Gronfier C, Procyk E (2011) Early Presymptomatic and Long-Term Changes of Rest Activity Cycles and Cognitive Behavior in a MPTP-Monkey Model of Parkinson’s Disease. PLoS One, 2011, 6(8):e23952 download
Danilenko KV, Plisov IL, Cooper HM, Wirz-Justice A, Hébert M (2011) Human cone light sensitivity and melatonin rhythms following 24-h continuous illumination Chronobiol Int, Vol. 28 (5) 407-414
Dollet A, Albrecht U, Cooper HM, Dkhissi-Benyahya O. (2010) Cones are required for normal temporal responses to light of phase shifts and clock gene expression. Chronobiology International 27(4): 768-81 download
Moussaouiti R, Bouhaddou N, Sabbar M, Cooper HM, Lakhdar-Ghazal N (2010) Phase and Period Responses of the Jerboa Jaculus orientalis to Short Light Pulses. Chronobiol Int, 27(7):1348-1364
Oosthuizen MK, Bennett NC, Cooper HM (2010) Photic induction of Fos in the SCN of African mole-rats: responses to increasing irradiance. Chronobiol Int, 27(8): 1532–1545
Mure LS, Cornut PL, Rieux C, Drouyer E, Gronfier C, Denis P, Cooper HM (2009) Melanopsin bistabiliy: A fly’s eye technology in the human retina. PloS One, 4(6):e5991
Cooper HM, Mure LS (2008) Expected and unexpected properties of melanopsin signalling. J Biol Rhythms 23(5): 392-93 download
Hut RA, Oklejewicz M, Rieux C, Cooper HM. (2008) Photic sensitivity ranges of hamster pupillary and circadian phase responses do not overlap. J Biol Rhythms 23: 37-48. download
Jeffery G, Levitt JB, Cooper HM (2008) Segregated hemispheric pathways through the optic chiasm distinguish primates from rodents Neuroscience 157(3):637-43 download
Drouyer E, Dkhissi-Benyahya O, Chiquet C, WoldeMussie E, Ruiz G, Wheeler LA, Denis P, Cooper HM. (2008) Glaucoma alters the circadian timing system PLoS ONE 3(12): e3931 download
Drouyer E, Rieux C, Hut RA, Cooper HM (2007) Responses of SCN neurons to light and dark adaptation: relative contributions of melanopsin and rod-cone inputs. J Neurosci 27(36): 9623-31. download
Dkhissi-Benyahya O, Gronfier C, De Vanssay W, Flamant F, Cooper HM (2007) Modeling the role of mid-wavelength cones in circadian responses to light. Neuron 53(5):677-87. download
Mure LS, Rieux C, Hattar S, Cooper HM. (2007) Melanopsin-dependent nonvisual responses: evidence for photopigment bistability in vivo J Biol Rhythms 22(5): 411-24 download
Neumane S, Vezoli J, Cooper HM, Procyk E, Kennedy H, Gronfier C (2007) Sleep and biological rythms disorders: early markers of Parkinson's Disease Eur J Med Res 12(4): 75
Dkhissi-Benyahya O, Rieux C, Hut RA, Cooper HM. (2006) Immunohistochemical evidence for a melanopsin cone in human retina. IOVS, 47(4):1636-41. download
Chiquet C, Claustrat B, Thuret G, Brun J, Cooper HM, Denis P. (2006) Melatonin concentrations in aqueous humor of glaucoma patients Am J Ophthalmol 142(2): 325-27 download
Chiquet, C. Drouyer E, Woldemussie E, Ruiz G, Wheeler L, Denis P, Cooper HM, Romanet J. P. (2006) Consequences of glaucoma on circadian and central visual systems J Fr Ophtalmol 29(7): 847-851 download
Schumann DM, Cooper HM, Hofmeyr MD, Bennett NC. (2006) Light-induced Fos expression in the suprachiasmatic nucleus of the four-striped field mouse, Rhabdomys pumilio: A southern African diurnal rodent Brain Res Bull 70(4-6): 270-7 download
Chiquet C, Dkhissi-Benyahya O, Cooper HM. (2005) Calcium-binding protein distribution in the retina of strepsirhine and haplorhine primates Brain Res Bull 68(3): 185-94 download
Vasicek CA, Oosthuizen MK, Cooper HM, Bennett NC. (2005) Circadian rhythms of locomotor activity in the subterranean Mashona mole rat, Cryptomys darlingi Physiol Behav 84(2): 181-91 download
Oosthuizen MK, Bennett NC, Cooper HM. (2005) Fos expression in the suprachiasmatic nucleus in response to light stimulation in a solitary and social species of African mole-rat (family Bathyergidae) Neuroscience 133(2): 555-60 download
Schumann DM, Cooper HM, Hofmeyr MD, Bennett NC. (2005) Circadian rhythm of locomotor activity in the four-striped field mouse, Rhabdomys pumilio: a diurnal African rodent Physiol Behav 85(3): 231-9 download
Glickman G, Hanifin J, Rollag MD, Wang J, Cooper HM, Brainard GC. (2003) Inferior retinal light exposure is more effective than superior retinal exposure in suppressing melatonins in humans J. Biol Rhythms, 18(1):71-79. download
Ahboucha S, Laalaoui A, Didier-Bazes M, Montange M, Cooper HM, Gamrani H. (2003) Differential patterns of glial fibrillary acidic protein-immunolabeling in the brain of adult lizards J Comp Neurol 464 (2): 159-71 download
Redlin U, Cooper HM, Mrosovsky N. (2003) Increased masking response to light after ablation of the visual cortex in mice Brain Res 965(1-2): 1-8 download
Oosthuizen MK, Cooper HM, Bennett NC. (2003) Circadian rhythms of locomotor activity in solitary and social species of African mole-rats (family: Bathyergidae) J Biol Rhythms 18(6): 481-90 download
Negroni J, Bennett NC, Cooper HM. (2003) Organization of the circadian system in the subterranean mole rat, Cryptomys hottentotus (Bathyergidae) Brain Res 967(1-2): 48-62 download
Chiquet C, Dkhissi-Benyahya O, Szel A, Degrip WJ, Cooper HM (2002) Characterisation of calbindin positive cones in four primate species. Neuroscience. 115(4):1323-33. download
Rieux C, Carney R, Lupi D, Dkhissi-Benyahya O, Janssen K, Cooper HM. (2002) Analysis of immunohistochemical label of Fos protein in the suprachiasmatic nucleus: comparison of different methods of quantification. J. Biol. Rhythms. 17(2): 121-136. download
Cernuda-Cernuda R, DeGrip WJ, Cooper HM, Nevo E, Garcia-Fernandez JM. (2002) The retina of Spalax ehrenbergi: novel histologic features supportive of a modified photosensory role Invest Ophthalmol Vis Sci 43(7): 2374-83 download
Lukats, A. Dkhissi-Benyahya O, Szepessy Z, Rohlich P, Vigh B, Bennett NC, Cooper HM, Szel A. (2002) Visual pigment coexpression in all cones of two rodents, the Siberian hamster, and the pouched mouse Invest Ophthalmol Vis Sci 43(7): 2468-73 download
Aujard F, Dkhissi-Benyahya O, Fournier I, Claustrat B, Schilling A, Cooper HM, Perret M (2001) Artificially accelerated aging by shortened photoperiod alters early gene expression (Fos) in the suprachiasmatic nucleus and sulfatoxymelatonin excretion in a small primate, Microcebus murinus. Neuroscience 105, 403-412 download
Chiquet C, Dkhissi-Benyahya O, Cooper HM, Claustrat B, Denis P. (2001) The eye and circadian rhythms J Fr Ophtalmol 24(6): 659-71
Dkhissi-Benyahya O, Szel A, Degrip WJ, Cooper HM. (2001) Short and mid-wavelength cone distribution in a nocturnal Strepsirrhine primate (Microcebus murinus) J Comp Neurol 438(4): 490-504 download
Dkhissi-Benyahya O, Sicard B, Cooper HM (2000) Effects of irradiance and stimulus duration on early gene expression (Fos) in the suprachiasmatic nucleus : temporal summation and reciprocity. J Neurosci 20(20):7790-7. download
Janssen JW, Bovee-Geurts PH, Peeters ZP, Bowmaker JK, Cooper HM, David-Gray ZK, Nevo E, DeGrip WJ (2000) A fully functional rod visual pigment in a blind mammal. A case for adaptive functional reorganization? J Biol Chem 275(49):38674-9 download
Chiquet C, Dkhissi-Benyahya O, Cooper HM. (1999) Is the study of blind patients useful for understanding light perception? Arch Ophthalmol 117: 848-49
Lupi D, Cooper HM, Froehlich A, Standford L, McCall MA, Foster RG. (1999) Transgenic ablation of rod photoreceptors alters the circadian phenotype of mice Neuroscience 89(2): 363-74 download
David-Gray ZK, Cooper HM, JanssenJW, Nevo E, Foster RG. (1999) Spectral tuning of a circadian photopigment in a subterranean 'blind' mammal (Spalax ehrenbergi) FEBS Lett 461(3): 343-7 download
Provencio I, Cooper HM, Foster RG. (1998) Retinal projections in mice with inherited retinal degeneration: implications for circadian photoentrainment J Comp Neurol 395 (4): 417-39 download
Tobler I, Herrmann M, Cooper HM, Negroni J, Nevo E, Achermann P. (1998) Rest-activity rhythm of the blind mole rat Spalax ehrenbergi under different lighting conditions Behav Brain Res 96(1-2): 173-83 download
Chevassus-au-Louis N, Cooper HM (1998) Is there a geniculohypothalamic tract in primates? A comparative immunohistochemical study in the circadian system of strepsirhine and haplorhine species Brain Res 805 (1-2): 213-9 download
Negroni J, Nevo E, Cooper HM. (1997) Neuropeptidergic organization of the suprachiasmatic nucleus in the blind mole rat (Spalax ehrenbergi) Brain Res Bull 44(5): 633-9 download
Rosa MG, Pettigrew JD, Cooper HM. (1996) Unusual pattern of retinogeniculate projections in the controversial primate Tarsius Brain Behav Evol 48(3):121-9
Herbin M, Rio JP, Reperant J, Cooper HM, Nevo E, Lemire M. (1995) Ultrastructural study of the optic nerve in blind mole-rats (Spalacidae, Spalax) Vis Neurosci 12(2): 253-61
Herbin M, Rio JP, Reperant J, Cooper HM, Lemire M. (1995) Ultrastructural analysis of the optic nerve in microphthalmic rodents (Spalax leucodon) C R Acad Sci III 316 (3): 251-8
Herbin M, Reperant J, Cooper HM. (1994) Visual system of the fossorial mole-lemmings, Ellobius talpinus and Ellobius lutescens J Comp Neurol 346(2): 253-75
Cooper HM, Parvopassu F, Herbin M, Magnin M. (1994) Neuroanatomical pathways linking vision and olfaction in mammals Psychoneuroendocrinology 19(5-7): 623-39
Vuillez P, Herbin M, Cooper HM, Nevo E, Pevet P. (1994) Photic induction of Fos immunoreactivity in the suprachiasmatic nuclei of the blind mole rat (Spalax ehrenbergi) Brain Res 654(1): 81-4
Tessonneaud A, Cooper HM, Caldani M, Locatelli A, Viguier-Martinez MC. (1994) The suprachiasmatic nucleus in the sheep: retinal projections and cytoarchitectural organization Cell Tissue Res 278(1): 65-84
Locatelli A, Caldani M, Tessonneaud A, Cooper HM, Viguier-Martinez MC. (1994) A new surgical approach to the ram suprachiasmatic nuclei J Neurosci Methods 51(2): 189-95
Cooper HM, Herbin M, Nevo E. (1993) Ocular regression conceals adaptive progression of the visual system in a blind subterranean mammal Nature 361(6408): 156-9 download
Cooper HM, Herbin M, Nevo E. (1993) Visual system of a naturally microphthalmic mammal: the blind mole rat, Spalax ehrenbergi J Comp Neurol 328 (3): 313-50
Mick G, Cooper H, Magnin M. (1993) Retinal projection to the olfactory tubercle and basal telencephalon in primates J Comp Neurol 327(2): 205-19
Cooper HM, Baleydier C, Magnin M. (1990) Macaque accessory optic system: I. Definition of the medial terminal nucleus. J Comp Neurol 302 (2): 394-404
Baleydier C, Magnin M, Cooper HM. (1990) Macaque accessory optic system: II. Connections with the pretectum J Comp Neurol 302(2): 405-16
Cooper HM, Mick G, Magnin M. (1989) Retinal projection to mammalian telencephalon. Brain Res 477 (1-2): 350-57
Pettigrew JD, Jamieson BG, Robson SK, Hall LS, McAnally KI, Cooper HM. (1989) Phylogenetic relations between microbats, megabats and primates (Mammalia: Chiroptera and Primates) Philos Trans R Soc Lond B Biol Sci
Magnin M, Cooper HM, Mick G. (1989) Retinohypothalamic pathway: a breach in the law of Newton-Muller-Gudden? Brain Res 488 (1-2): 390-7
Cooper HM (1987) Accessory optic system of an anthropoid primate, the gibbon (Hylobates concolor): evidence of a direct retinal input to the medial terminal nucleus J Comp Neurol 259(4):467-482
Cooper HM, Magnin M. (1987) A common mammalian plan of accessory optic system organization revealed in all primates Nature 324 (6096): 457-9 download
Cooper HM (1986) A microcomputer data acquisition-telemetry system: a study of activity in the bat Journal of Wildlife management 49(850-854)
Cooper HM. (1986) The accessory optic system in a prosimian primate (Microcebus murinus): evidence for a direct retinal projection to the medial terminal nucleus J Comp Neurol 249(1): 28-47
Charles-Dominique P, Cooper HM (1986) Frugivorie et transport de graines de cercopria par les chauve-souris de Guyane Mémoire du M.N.H.M (Paris) 132: 145-57
Cooper HM, Charles-Dominique P, Vienot P. (1986) Signification de la coloration des fruits en fonction de la vision des vertérébrés consommateurs Mémoires du M.N H.N. (Paris) 132: 131-43
Orsini JC, Jourdan F, Cooper HM, Monmaur P. (1985) Influence of female odors on lateral hypothalamus in the male rat. Semiquantitative deoxyglucose analysis Physiol Behav 35(4): 509-16
Cooper HM (1980) Radioautography 2-deoxyglucose patterns elicited by female odors in the male rat olfactory bulb Olfaction and taste VII 323-9
Cooper HM, Kennedy H, Magnin M, Vital-Durand F. (1979) Thalamic projections to area 17 in a prosimian primate, Microcebus murinus. J Comp Neurol, 1979, 187:145-167
Cooper HM (1978) Learning set in prosimians Recent advances in Primatology 1: 941-9