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Conference by Adrien Meguerditchian

Published on March 28, 2017

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Dr Emmanuel Procyk

Position: Research Associate

Company: Inserm u846

Mailing Address:
18 avenue du Doyen Jean L�pine

69675 - Bron Cedex - France
External Link:

Investissements d'Avenir : LabEx CORTEX - European funded projects
Neurobiology of executive functions - Teams (leader)

Personnal pages
Prefrontal cortico-cortical interactions
SITES of related interests
Brain Signals UNIT/LFP
PRIMAGE: Brain Imaging in Primates

Research interest

What are the neural mechanisms producing higher cognitive functions, and in particular those allowing flexible and voluntary behaviours? This is the main theme of my research. It addresses action and outcome valuation, cognitive control / working memory and sequential planning, and how these processes lead to rapid adaptations of behaviour.
Understanding these mechanisms requires investigating brain functions from behavioural to basic neurophysiological and neurochemical levels. System neuroscience is our approach, and it guides most projects in the NEF lab.

Our research is devoted to uncovering the functional specificities and relationships between prefrontal areas. Integrating a realistic quantitative description of prefrontal cortico-cortical connectivity of prefrontal areas with other brain structures is now an important axis of our research in interaction with Henry Kennedy’s lab. The aim is to bind network neurophysiological and pharmacological data with neuroanatomy. Finally we develop, in collaboration with PF Dominey’s lab, a computational approach to understand functions of networks devoted to higher cognition.

Finally, most approaches in our research leads toward understanding the specificity of primate brain networks, function, organization, and computational abilities compared to other species.


Procyk, E., Wilson C.R.E., Stoll, F.M., Faraut M.C.M., Petrides M., Amiez C. (2016) Midcingulate motor map and feedback detection: converging data from humans and monkeys. Cerebral Cortex, 26: 467-476 download
Stoll* F., Wilson* C.R.E., Faraut M.C.M., Vezoli J., Knoblauch K., Procyk E. (2016) The effects of cognitive control and time on beta oscillations. Cerebral Cortex, 26: 1715-1732
Stoll FM, Fontanier V, Procyk E. (2016) Specific frontal neural dynamics contribute to decisions to check. Nat Commun. 2016 Jun 20;7:11990. doi: 10.1038/ncomms11990
Enel P, Procyk E, Quilodran R, Dominey PF. (2016) Reservoir Computing Properties of Neural Dynamics in Prefrontal Cortex. PLoS Comput Biol. 2016 Jun 10;12(6):e1004967. doi: 10.1371/journal.pcbi.1004967. eCollection 2016.
Wilson CRE; Vezoli J; Stoll FM; Faraut MCM; Leviel V; Knoblauch K; Procyk E. (2016) Prefrontal Markers and Cognitive Performance Are Dissociated during Progressive Dopamine Lesion PLoS Biol 14(11): e1002576. download
Faraut M.C., Procyk E., Wilson C.R.E. (2016) Learning to learn about uncertain feedback. Learning and Memory, 23: 90-98.
Amiez C, Champod AS, Wilson CR, Procyk E, Petrides M (2015) A unilateral medial frontal cortical lesion impairs trial and error learning without visual control Neuropsychologia. 2015 Aug;75:314-21
Khamassi M, Quilodran R, Enel P, Dominey PF, Procyk E (2015) Behavioral Regulation and the Modulation of Information Coding in the Lateral Prefrontal and Cingulate Cortex Cereb Cortex. 2015 Sep;25(9):3197-218 download
Logiaco L, Quilodran R, Procyk E, Arleo A (2015) Spatiotemporal Spike Coding of Behavioral Adaptation in the Dorsal Anterior Cingulate Cortex. PLoS Biol. 2015 Aug 12;13(8):e1002222. doi: 10.1371/journal.pbio.1002222
Fifel K, Vezoli J, Dzahini K, Claustrat B, Leviel V, Kennedy H, Procyk E, Dkhissi-Benyahya O, Gronfier C, Cooper HM (2014) Alteration of daily and circadian rhytms following dopamine depletion in MPTP treated Non-Human Primates. PLoS One, 2014, 9(1):e86240
Vezoli J, Wianny F, Dzahini K, Dolmazon V, Bernat A, Fifel K, Wilson CRE, Gronfier C, Procyk E, Cooper HM, Savatier P, Dehay C, Kennedy H (2014) Host-integration of neural precursors in parkinsonian monkeys: outcome on clinical, cognitive, circadian and DA function. Cell Symposia: Translational Neuroscience. Arlington, VA, USA. download
Vezoli J, Dzahini K, Costes N, Wilson CR, Fifel K, Cooper HM, Kennedy H, Procyk E (2014) Increased DAT binding in the early stage of the dopaminergic lesion: a longitudinal [11C]PE2I binding study in the MPTP-monkey. Neuroimage 102:249-261
Amiez C, Neveu R, Warrot D, Petrides M, Knoblauch K, Procyk E (2013) The location of feedback-related activity in the mid-cingulate cortex is predicted by local morphology. The Journal of Neuroscience, 33, 2217–2228.
Khamassi M, Enel P, Dominey PF, Procyk E (2013) Medial prefrontal cortex and the adaptive regulation of reinforcement learning parameters. Prog Brain Res, 202:441-464
Amiez C, Sallet J, Procyk E, Petrides M (2012) Modulation of feedback related activity in the rostral anterior cingulate cortex during trial and error exploration. Neuroimage. 63: 1078-1090 download
Khamassi M, Wilson C, Rothé R, Quilodran R, Dominey PF, Procyk E (2011) Meta-learning, cognitive control, and physiological interactions between medial and lateral prefrontal cortex. Neural Basis of Motivational and Cognitive Control, MIT Press, publisher.
Vezoli J, Fifel K, Leviel V, Dehay C, Kennedy H, Cooper HM, Gronfier C, Procyk E (2011) Early Presymptomatic and Long-Term Changes of Rest Activity Cycles and Cognitive Behavior in a MPTP-Monkey Model of Parkinson’s Disease. PLoS One, 2011, 6(8):e23952 download
Rothé M, Quilodran R, Sallet J, Procyk E (2011) Coordination of high gamma activity in anterior cingulate and lateral prefrontal cortical areas during adaptation. Coordination of high gamma activity in anterior cingulate and lateral prefrontal cortical areas during adaptation download
Khamassi M, Lallée S, Enel P, Procyk E, Dominey PF (2011) Robot cognitive control with a neurophysiologically inspired reinforcement learning model. Front Neurorobot. 5:1-14. download
Khamassi M, Quilodran R, Enel P, Procyk E, Dominey PF (2010) A computational model of integration between reinforcement learning and task monitoring in the prefrontal cortex. (In press) In Proc. Int. Conf. on Simulation of Adaptive Behaviour. Eds Springer Verlag. download
Vezoli J, Procyk E (2010) "Controversy about FRPs recorded in non-human primates!" J Neurosci download
Vezoli J, Procyk E (2009) Frontal Feedback-Related Potentials in Nonhuman Primates: Modulation during Learning and under Haloperidol J Neurosci 29 (50): 15675-15683 download
Quilodran R, Rothé M, Procyk E (2008) Behavioral shifts and action valuation in the anterior cingulate cortex. Neuron download
Sallet J, Quilodran R, Rothé M, Vezoli J, Joseph JP, Procyk E. (2007) Expectations, gains and losses in the anterior cingulate cortex. Cogn Affect Behav Neurosci 7(4), 327-36. download
Neumane S, Vezoli J, Cooper HM, Procyk E, Kennedy H, Gronfier C (2007) Sleep and biological rythms disorders: early markers of Parkinson's Disease Eur J Med Res 12(4): 75
Procyk E, Goldman-Rakic PS (2006) Modulation of dorsolateral prefrontal delay activity during self-organized behavior. J Neurosci 26(44):11313-23. download
Amiez C, Joseph JP, Procyk E (2006) Reward Encoding in the Monkey Anterior Cingulate Cortex. Cereb Cortex 16(7):1040-55 download
Amiez C, Joseph JP, Procyk E (2005) Anterior cingulate error-related activity is modulated by predicted reward. Eur J Neurosci 21(12):3447-52 download
Constantinidis C, Procyk E. (2004) The primate working memory networks. Cogn Affect Behav Neurosci 4(4):444-65. download
Amiez C, Procyk E, Honore J, Sequeira H, Joseph JP (2003) Reward anticipation, cognition, and electrodermal activity in the conditioned monkey. Exp Brain Res 149(3):267-75 download
Procyk E, Joseph JP (2001) Characterization of serial order encoding in the monkey anterior cingulate sulcus Eur J Neurosci 14:1041-6. download
Procyk E, Tanaka YL, Joseph JP (2000) Anterior cingulate activity during routine and non-routine sequential behaviors in macaques. Nat Neurosci 3(5):502-8 download
Procyk E, Dominey PF, Amiez C, Joseph J-P (2000) The effects of sequence structure and reward schedule on serial reaction time learning in the monkey Cogn Brain Res 9(3):239-48 download
Le Goualher G, Procyk E, Collins DL, Venugopal R, Barillot C, Evans AC. (1999) Automated extraction and variability analysis of sulcal neuroanatomy. IEEE Trans Med Imaging 18(3): 206-17 download
Decety J, Grèzes J, Costes N, Perani D, Jeannerod M, Procyk E, Grassi F, Fazio F. (1997) Brain activity during observation of actions. Influence of action content and subject's strategy. Brain.120 ( Pt 10):1763-77 download
Procyk E, Joseph JP. (1996) Spatial reasoning in the monkey. Brain Res Cogn Brain Res. 5(1-2):131-5 download
Procyk E, Joseph JP (1996) Problem solving and logical reasoning in the macaque monkey. Behav Brain Res. 82(1):67-78 download