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Stem-cell and Brain Research Institute
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Conference by Adrien Meguerditchian

Published on March 28, 2017

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Colette Dehay

Position: Research Director

Company: Inserm u846

Mailing Address:
18 avenue du Doyen Jean Lépine

69675 - Bron Cedex - France
External Link: www.sbri.fr
E-mail: Colette.Dehay@inserm.fr
Phone: 33 4 72 91 34 71
Fax: 04 72 91 34 61

Cell replacement therapy for early Parkinson’s disease - Transversal projects
Investissements d'Avenir : LabEx DEVweCAN - European funded projects
Investissements d'Avenir : LabEx CORTEX - European funded projects
Investissements d'Avenir : Cesame - Plateforme d'ingénierie cellulaire - Platforms
Stem cells and cortical development - Teams (leader)

Research interest

Team leader

Pfeiffer M, Betizeau M, Waltispurger J, Pfister SS, Douglas RJ, Kennedy H, Dehay C (2016) Unsupervised lineage-based characterization of primate precursors reveals high proliferative and morphological diversity in the OSVZ. J Comp Neurol. 2016; 524:535-63
Fame RM, Dehay C, Kennedy H, Macklis JD (2016) Subtype-specific genes that characterize subpopulations of callosal projection neurons in mouse identify molecularly homologous populations in macaque cortex. Cereb Cortex, in press 10.1093/cercor/bhw023
Delaunay D, Robini MC, Dehay C (2015) Mitotic spindle asymmetry in rodents and primates: 2D vs. 3D measurement methodologies Front Cell Neurosci. 2015 Feb 9;9:33
Adnani L, Langevin LM, Gautier E, Dixit R, Parsons K, Li S, Kaushik G, Wilkinson G, Wilson R, Childs S, Nguyen MD, Journot L, Dehay C, Schuurmans C. (2015) Zac1 regulates the differentiation and migration of neocortical neurons via Pac1 J Neurosci. 2015 Sep 30;35(39):13430-47. doi: 10.1523/JNEUROSCI.0777-15.2015.
Dehay C, Kennedy H, Kosik KS (2015) The outer subventricular zone and primate-specific cortical complexification. Neuron, 85:693-94
Markov NT, Ercsey-Ravasz MM, Ribeiro Gomes AR, Lamy C, Magrou L, Vezoli J, Misery P, Falchier A, Quilodran R, Gariel MA, Sallet J, Gamanut R, Huissoud C, Clavagnier S, Giroud P, Sappey-Marinier D, Barone P et al (2014) A weighted and directed interareal connectivity matrix for macaque cerebral cortex. Cereb Cortex, 2014, 24(1):17-36 download
Markov NT, Vezoli J, Chameau P, Falchier A, Quilodran R, Huissoud C, Lamy C, Misery P, Giroud P, Ullman S, Barone P, Dehay C, Knoblauch K, Kennedy H. (2014) The anatomy of hierarchy: Feedforward and feedback pathways in macaque visual cortex. J Comp Neurol, 2014, 522(1):225-259 download
Delaunay D, Cortay V, Patti D, Knoblauch K, Dehay C (2014) Mitotic spindle asymmetry: a Wnt/PCP regulated mechanism generating asymmetrical division in cortical precursors. Cell reports 6:1-15
Arcila ML, Betizeau M, Cambronne L, Guzman E, Doerflinger N, Bouhallier F, Zhou H, Wu B, Borello U, Huissoud C, Goodman R, Dehay C, Kosik KS (2014) Novel primate miRNAs co-evolved with ancient target genes in germinal zone specific expression patterns Neuron 81 (6): 1255-1262
Vezoli J, Wianny F, Dzahini K, Dolmazon V, Bernat A, Fifel K, Wilson CRE, Gronfier C, Procyk E, Cooper HM, Savatier P, Dehay C, Kennedy H (2014) Host-integration of neural precursors in parkinsonian monkeys: outcome on clinical, cognitive, circadian and DA function. Cell Symposia: Translational Neuroscience. Arlington, VA, USA. download
Caloone J, Huissoud C, Vincenot J, Kocot A, Dehay C, Chapelon J, Rudigoz R, Melodelima D (2014) High-Intensity Focused Ultrasound applied to the placental unit using a toroidal-shaped transducer: a preliminary ex-vivo study. Ultrasound Obst Gynecol, DOI :10.1002/uog.13374
Markov N.T., Ercsey-Ravasz M., Lamy C., Ribeiro-Gomes A.R., Magrou L., Misery P., Giroud P. Barone P., Dehay C., Toroczkai Z., Knoblauch, K., Van Essen D.C., Kennedy H. (2013) The role of long-range connections on the specificity of the macaque interareal cortical network. Proc Nat Acad Sci USA, 2013, 110, 5187-5192 download
Betizeau M, Cortay V, Patti D, Pfister S, Gautier E, Bellemin-Ménard A, Afanassieff M, Huissoud C, Douglas RJ, Kennedy K, Dehay C (2013) Precursor Diversity and Complexity of Lineage Relationships in the Outer Subventricular Zone of the Primate. Neuron 80 :442-457 download
Kennedy H, Dehay C (2012) Self-organization and interareal networks in the primate cortex. Prog Brain Res, 2012, 195:341-360 download
Markov NT, Misery P, Falchier A, Lamy C, Vezoli J, Quilodran R, Gariel MA, Giroud P, Ercsey-Ravasz M, Pilaz LJ, Huissoud C, Barone P, Dehay C, Toroczkai Z, Van Essen DC, Kennedy H, Knoblauch K (2011) Weight Consistency Specifies Regularities of Macaque Cortical Networks. Cereb Cortex. 2011, 21:1254-1272 download
Wianny F, Bourillot PY, Dehay C. (2011) Embryonic stem cells in non-human primates: An overview of neural differentiation potential. Differentiation 81(3):142-52. download
Vezoli J, Fifel K, Leviel V, Dehay C, Kennedy H, Cooper HM, Gronfier C, Procyk E (2011) Early Presymptomatic and Long-Term Changes of Rest Activity Cycles and Cognitive Behavior in a MPTP-Monkey Model of Parkinson’s Disease. PLoS One, 2011, 6(8):e23952 download
Dolmazon V, Alenina N, Markossian S, Mancip J, van de Vrede Y, Fontaine E, Dehay C, Kennedy H, Bader M, Savatier P, Bernat A (2011) Forced expression of Lmx1b enhances differentiation of mouse ES cells into serotonergic neurons. Stem Cells Dev, 2011, 20:301-311
Markov NT, Ercsey-Ravasz MM, Gariel MA, Dehay C, Knoblauch A, Toroczkai Z, Kennedy H (2011) The tribal networks of the cerebral cortex. In: Cerebral Plasticity (Chalupa LM, Berardi N, Caleo M, Galli-Resta L, Pizzorusso T, eds), p 275-290. Cambridge MA: MIT Press.
Bonnefont J, Laforge T, Plastre O, Beck B, Sorce S, Dehay C, Krause KH (2010) Primate-specific RFPL1 gene controls cell-cycle progression through cyclin B1/Cdc2 degradation. Cell Death Differ, 18(2):293-303
Abellan A, Menuet A, Dehay C, Medina L, Retaux S (2010) Differential expression of LIM-homeodomain factors in Cajal-Retzius cells of primates, rodents and birds. Cereb Cortex, 20(8):1788-1798
Dehay C, Kennedy H (2009) Transcriptional regulation and alternative splicing make for better brains. Neuron, 2009, 62:455-457 download
Pinto L, Drechsel D, Schmid MT, Ninkovic J, Irmler M, Brill MS, Restani L, Gianfranceschi L, Cerri C, Weber SN, Tarabykin V, Baer K, Guillemot F, Beckers J, Zecevic N, Dehay C, Caleo M, Schorle H, Götz M (2009) AP2 regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex Nat Neurosci, 12(10):1229-37
Fish JL, Dehay C, Kennedy H, Huttner WB (2008) Making bigger brains-the evolution of neural-progenitor-cell division. J Cell Sci. 2008 121(Pt 17):2783-93 download
Dehay C, Kennedy H (2007) Cell-cycle control and cortical development. Nat Rev Neurosci, 2007, 8(6):438-50 download
Kennedy H, Douglas R, Knoblauch K, Dehay C. (2007) Self-organization and pattern formation in primate cortical networks. Novartis Found Symp 288: 178-94 discussion 195-8, 276-81 download
Pollard KS, Salama SR, Lambert N, Lambot MA, Coppens S, Pedersen JS, Katzman S, King B, Onodera C, Siepel A, Kern AD, Dehay C, Igel H, Ares M Jr, Vanderhaegen P & Haussler D (2006) An RNA gene expressed during cortical development evolved rapidly in humans Nature 443:167-72 download
Lukaszewicz A, Cortay V, Giroud P, Berland M, Smart I, Kennedy H, Dehay C (2006) The concerted modulation of proliferation and migration contributes to the specification of the cytoarchitecture and dimensions of cortical areas. Cereb Cortex, 2006, 16 Suppl 1:i26-34 download
Molnar Z, Metin C, Stoykova A, Tarabykin V, Francis F, Meyer G, Dehay C, Kennedy H (2006) Comparative aspects of cerebral cortical development. Eur J Neurosci, 2006, 23:921-934 download
Price DJ, Kennedy H, Dehay C, Zhou L, Mercier M, Jossin Y, Goffinet AM, Tissir F, Molnar Z (2006) The development of cortical connections. Eur J Neurosci, 2006, 23:910-920 download
Huberman AD, Dehay C, Berland M, Chalupa LM, Kennedy H (2005) Early and rapid targeting of Eye-Specific Axonal Projections to the dorsal lateral Geniculate Nucleus in the Fetal Macaque. J Neurosci, 2005, 25:4014-4023 download
Lukaszewicz A, Savatier P, Cortay V, Giroud P, Huissoud C, Berland M, Kennedy H, Dehay C (2005) G1 phase regulation, Area-Specific cell cycle control, and Cytoarchitectonics in the Primate Cortex. Neuron, 2005, 47:353-364 download
Seibt J, Schuurmans C, Dehay C, Vanderhagen P, Guillemot F, Polleux F (2003) Neurogenin2 specifies the connectivity of thalamic neurons by controlling axon responsiveness to intermediate target cues. Neuron 39:439-52 download
Fluckiger AC, Dehay C, Savatier P. (2003) Embryonic stem cells and cell replacement therapies in the nervous system Med Sci (Paris). 19(6-7):699-708 download
Lukaszewicz A, Savatier P, Cortay V, Kennedy H, Dehay C (2002) Contrasting Effects of Basic Fibroblast Growth Factor and Neurotrophin 3 on Cell Cycle Kinetics of Mouse Cortical Stem Cells. J Neurosci, 2002, 12(5) : 6610-6622 download
Smart IH, Dehay C, Giroud P, Berland M, Kennedy H (2002) Unique Morphological Features of the Proliferative Zones and Postmitotic Compartments of the Neural Epithelium Giving Rise to Striate and Extrastriate Cortex in the Monkey Cerebral Cortex 12:37-53 download
Berthet C, Guehenneux F, Revol V, Samarut C, Lukaszewicz A, Dehay C, Dumontet C, Magaud JP, Rouault JP (2002) Interaction of PRMT1 with BTG/TOB protzins in cell signalling: molecular analysis and functional aspects. Genes Cells 7 (1):29-39 download
Dehay C, Savatier P, Cortay V, Kennedy H (2001) Cell-cycle kinetics of neocortical precursors are influenced by embryonic thalamic axons. J Neurosci, 2001, 21:201-214 download
Polleux F, Dehay C, Goffinet A, Kennedy H (2001) Pre-and Post-mitotic Events Contribute to the Progressive Acquistion of Area-specific Connectional Fate in the Neocortex. Cereb Cortex, 2001, 11:1027-1039 download
Vallier L, Mancip J, Markossian S, Lukaszewicz A, Dehay C, Metzger D, Chambon P, Samarut J, Savatier P (2001) An efficient system for conditional gene expression in embryonic stem cells and their in vitro and in vivo differentiated derivatives. Proc Nat Acad Sci USA 98:2467-2472 download
Kennedy H, Dehay C. (2001) Gradients and boundaries: limits of modularity and its influence on the isocortex Dev Sci 4:147-48 download
Kennedy H, Dehay C. (2001) La longue maturation de la fonction visuelle Science et vie 216 (Hors série) 60-67
Wefers CJ, Dehay C, Berland M, Kennedy H (2000) Binocular competition does not regulate retinogeniculate arbor size in fetal monkey. J Comp Neurol 427:362-9 download
Snider CJ, Dehay C, Berland M, Kennedy H (1999) Prenatal development of Retinogeniculate axons in the macaque monkey during segregation of binocular inputs. J Neurosci, 1999, 19: 220-228 download
Barone P, Berland M, Dehay C, Kennedy H. (1999) Développement des connexions cortico-corticales du primate. Arch Pediatr. 6 Suppl 2:193s-194s download
Batardière A, Barone P, Dehay C, Kennedy H (1998) Area-specific laminar distribution of cortical feedback neurons projecting to cat area 17: Quantitative analysis in the adult and during ontogeny. J Comp Neurol, 1998, 396:493-510 download
Polleux F, Dehay C, Kennedy H (1998) Neurogenesis and commitment of corticospinal neurons in reeler. J Neurosci, 1998, 18:9910-9923 download
Kennedy H, Dehay C, Savatier P. (1998) Modulation du cycle cellulaire et spécification des aires du neocortex Arch Physiol Biochem 106:1-5
Polleux F, Dehay C, Kennedy H (1997) The Timetable of Laminar Neurogenesis Contributes to the Specification of Cortical Areas in Mouse Isocortex. J Comp Neurol, 1997, 385:95-116 download
Polleux F, Dehay C, Moraillon B, Kennedy H (1997) Regulation of Neuroblast Cell-Cycle Kinetics Plays a Crucial Role in the Generation of Unique Features of Neocortical Areas. J Neurosci, 1997, 17:7763-7783 download
Fraichard A, Chassande O, Plateroti M, Roux JP, Trouillas J, Dehay C et al. (1997) The T3R alpha gene encoding a thyroid hormone receptor is essential for post-natal development and thyroid hormone production. Embo J 16:4412-20 download
Kennedy H, Dehay C (1997) Cortical development: a progressive and selective mesh, with or without constructivism. Behav Brain Res, 1997, 20:570-571 download
Dehay C, Giroud P, Berland M, Killackey H, Kennedy H (1996) The contribution of thalamic input to the specification of cytoarchitectonic cortical fields in the primate: effects of bilateral enucleation in the foetal monkey on the boundaries and dimensions of striate and extrastriate cortex. J Comp Neurol, 1996, 367:70-89 download
Barone P, Dehay C, Berland M, Kennedy H (1996) The role of directed growth and target selection in the formation of cortical pathways: prenatal development of the projection of area V2 to area V4 in the monkey. J Comp Neurol 374:1-20 download
Dehay C, Giroud P, Berland M, Killackey H, Kennedy H (1996) Phenotypic Characterisation Respecified Visual Cortex Subsequent to Prenatal Enucleation in the Monkey : Development of Acetylcholinesterase and Cytochrome Oxydase Patterns. J Comp Neurol, 1996, 376:386-402 download
Barone P, Dehay C, Berland M, Bullier J, Kennedy H (1995) Developmental remodeling of primate visual cortical pathways. Cereb Cortex, 1995, 5:22-38 download
Fraichard A, Chassande O, Bilbault G, Dehay C, Savatier P, Samarut J (1995) In vitro differentiation of ES cells into glial cells and functional neurons. J Cell Sci 108:3181-8 download
Barone P, Dehay C, Berland M, Kennedy H. (1994) Developmental changes in the distribution of acetylcholinesterase in the extrastriate visual cortex of the monkey. Dev Brain Res, 1994, 77:290-294 download
Kennedy H, Dehay C (1994) Cortex cérébral: le poids des gènes La Recherche 263: 332-33 download
Kennedy H, Dehay C (1993) Cortical specification of mice and men. Cerebral Cortex, 1993, 3(3):27-35 download
Dehay C, Giroud P, Berland M, Smart I, Kennedy H (1993) Modulation of the cell cycle contributes to the parcellation of the primate visual cortex. Nature, 1993, 366:464-466 download
Kennedy H, Dehay C. (1993) The importance of developmental timing in cortical specification. Persp Dev Neurobio, 1993, 1:93-99 download
Meissirel C, Dehay C, Kennedy H. (1993) Transient cortical pathways in the pyramidal tract of the neonatal ferret. J Comp Neurol, 1993, 337:193-213 download
Kennedy H, Dehay C (1993) Le développement du cortex cérébral La Recherche 251(24): 132-41 download
Anderson JC, Dehay C, Friedlander MJ, Martin KA, Nelson JC. (1992) Synaptic connections of physiologically identified geniculocortical axons in kitten cortical area 17. Proc Biol Sci. 22;250(1329):187-94
Meissirel C, Dehay C, Berland M, Kennedy H (1991) Segregation of callosal and association pathways during development in the visual cortex of the primate. J Neurosci, 1991, 11:3297-3316 download
Dehay C, Horsburgh G, Berland M, Killackey H, Kennedy H. (1991) The effects of bilateral enucleation in the primate fetus on the parcellation of visual cortex. Dev Brain Res, 1991, 62:137-141 download
Dehay C, Douglas RJ, Martin KA, Nelson C. (1991) Excitation by geniculocortical synapses is not 'vetoed' at the level of dendritic spines in cat visual cortex. J Physiol. 440:723-34
Dehay C, Kennedy H, Smart IHM, Berland M. (1991) Cell Production Gradients in the Developing Primate Visual-Cortex J Physiol London 434 (MAR) p13-13
Dumas AM, Berland M, Dehay C, Kennedy H. (1991) Development of the cerebral cortex in the primate Sci Tech Anim Lab 16(4): 251-256 download
Kennedy H, Dehay C. (1990) La chronologie de la corticogénèse et ses implications dans l'émergence des fonctions psychiques et cognitives Neuro-Psy 5: 201-216
Kennedy H, Dehay C, Horsburgh G. (1990) Striate cortex periodicity. Nature, 1990, 348:494 download
Kennedy H, Meissirel C, Dehay C, Berland M, Dumas A M. (1990) Remodeling of cortical connections during prenatal development in the monkey J Physiol. 430:116-116
Meissirel C, Dehay C, Berland M, Kennedy H. (1990) Incidence of visual cortical neurons which have axon collaterals projecting to both cerebral hemispheres during prenatal primate development. Dev Brain Res, 1990, 56:123-126 download
Dehay C, Horsburgh G, Berland M, Killackey H, Kennedy H (1989) Maturation and connectivity of the visual cortex in monkey is altered by prenatal removal of retinal input. Nature, 1989, 337:265- 267 download
Kennedy H, Bullier J, Dehay C (1989) Transient projection from the superior temporal sulcus to area 17 in the newborn macaque monkey. Proc Natl Acad Sci USA, 1989, 86:8093-8097 download
Bullier J, Dehay C, Dreher B. (1989) Bihemispheric Axonal Bifurcation of the Afferents to the Visual Cortical Areas during Postnatal Development in the Rat. Eur J Neurosci. 2(4):332-343 download
Dreher B, Dehay C, Bullier J. (1989) Bihemispheric Collateralization of the Cortical and Subcortical Afferents to the Rat's Visual Cortex. Eur J Neurosci.2(4):317-331 download
Dehay C, Kennedy H, Bullier J, Berland M. (1988) Absence of interhemispheric connections of area 17 during development in the monkey. Nature, 1988, 331:348-350 download
Dehay C, Kennedy H. (1988) The maturational status of thalamocortical and callosal connections of visual areas V1 and V2 in the newborn monkey. Behav Brain Res, 1988, 29:237-244 download
Dehay C, Kennedy H, Bullier J. (1988) Characterization of transient cortical projections from auditory, somatosensory, and motor cortices to visual areas 17, 18, and 19 in the kitten. J Comp Neurol, 1988, 272:68-89 download
Kennedy H, Dehay C. (1988) Functional implications of the anatomical organization of the callosal projections of visual areas V1 and V2 in the Macaque monkey. Behav Brain Res, 1988, 29:225-236 download
Berland M, Bullier J, Dehay C, Jaffarbandjee Z, Kennedy H. (1987) Callosal connections and cytochrome-oxidase stainning of visual areas V1 and V2 in the prenatal monkey (macaca-irus) J Physiol, London 382; 95-95
Kennedy H, Dehay C. (1987) Le développement du cerveau La Recherche 184: 26-34 download
Dehay C, Hein A, Kennedy H (1987) A transient cortical projection to the pyramidal tract in the neonatal ferret J Phys Lon 382:96-97 download
Dehay C, Kennedy H, Bullier J. (1986) Callosal connectivity of areas V1 and V2 in the newborn monkey. J Comp Neurol, 1986, 254:20-33 download
Kennedy H, Dehay C, Bullier J. (1986) The organization of the callosal connections of visual areas V1 and V2 in the macaque monkey. J Comp Neurol, 1986, 247:398-415 download
Kennedy H, Bullier J, Dehay C. (1985) Cytochrome oxidase activity in the striate cortex and lateral geniculate nucleus of the newborn and adult macaque monkey. Exp Brain Res, 1985, 61:204-209 download
Bullier J, Dehay C, Kennedy H. (1984) Axonal bifurcation and cortico-cortical connectivity in the kitten visual cortex J Physiol 353 p22
Dehay C, Bullier J, Kennedy H. (1984) Transient projections from the fronto-parietal and temporal cortex to areas 17, 18 and 19 in the kitten. Exp Brain Res, 1984, 57:208-212 download