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Stem-cell and Brain Research Institute
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Conference by Adrien Meguerditchian

Published on March 28, 2017

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Claude Gronfier

Position: Research Associate

Company: Inserm u846

Mailing Address:
18 avenue du Doyen Jean Lépine

69675 - Bron Cedex - France
External Link: www.sbri.fr
E-mail: claude.gronfier@inserm.fr

Circadian Metrology - PI : Claude Gronfier - European funded projects (leader)
Chronobiology - Platforms
- (leader)
Chronobiology and affective disorders - Teams
- (leader)

Personnal pages

Research interest

My research focuses on how light synchronizes physiology, including the circadian timing system, to the 24h day in humans.  My projects investigate the mechanisms involved in non-visual photoreception, the effects of light on physiological functions (alertness, cognition, mood), and how light could be used/designed to treat circadian, mood, vigilance, and sleep disorders, in shiftwork and pathological conditions (Ocular diseases, neurodegenerative disorders).

Raymond P. Najjar; Petteri Teikari; Pierre-Loďc Cornut; Kenneth Knoblauch; Howard M. Cooper; Claude Gronfier (2016) Heterochromatic Flicker Photometry for Objective Lens Density Quantification Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1063-1071. doi:10.1167/iovs.15-18642
Wright KP Jr, Drake AL, Frey DJ, Fleshner M, Desouza CA, Gronfier C and Czeisler CA (2015) Influence of sleep deprivation and circadian misalignment on cortisol, inflammatory markers, and cytokine balance Brain Behav Immun. 2015 Jul;47:24-34
A. Etiévant, C. Oosterhof, C. Bétry, E. Abrial, M. Novo-Perez, R. Rovera, H. Scarna, C. Devader, J. Mazella, G. Wegener, C. Sánchez, O. Dkhissi-Benyahya, C. Gronfier, V. Coizet, J.M. Beaulieu, P. Blier, G. Lucas, N. Haddjeri (2015) Astroglial control of the antidepressant-like effects of prefrontal cortex deep brain stimulation EbioMedecine. 2(8):896-906
Najjar RP, Chiquet C, Teikari P, Cornut PL, Claustrat B, Denis P, Cooper HM, Gronfier C (2014) Aging of Non-Visual Spectral Sensitivity to Light in Humans: Compensatory Mechanisms? Plos One, 9(1): e85837 download
Fifel K, Vezoli J, Dzahini K, Claustrat B, Leviel V, Kennedy H, Procyk E, Dkhissi-Benyahya O, Gronfier C, Cooper HM (2014) Alteration of daily and circadian rhytms following dopamine depletion in MPTP treated Non-Human Primates. PLoS One, 2014, 9(1):e86240
Najjar R.P., Wolf L, Taillard J, Schlangen L., Salam A, Cajochen C, Gronfier C (2014) Chronic artificial blue-enriched white light is an effective countermeasure to delayed circadian phase and neurobehavioral decrements. Plos One, 9:e102827
Vezoli J, Wianny F, Dzahini K, Dolmazon V, Bernat A, Fifel K, Wilson CRE, Gronfier C, Procyk E, Cooper HM, Savatier P, Dehay C, Kennedy H (2014) Host-integration of neural precursors in parkinsonian monkeys: outcome on clinical, cognitive, circadian and DA function. Cell Symposia: Translational Neuroscience. Arlington, VA, USA. download
Teikari P, Najjar R P, Malkki H, Knoblauch K, Dumortier D, Gronfier C, Cooper HM. (2012) An inexpensive Arduino-based LED stimulator system for vision research. Journal of Neuroscience Methods 211, 227–236 download
Teikari P, Najjar RP, Malkki H, Knoblauch K, Dumortier D, Cornut PL, Denis P, Cooper HM, Gronfier C (2012) Refined flicker photometry technique to measure ocular lens density. Journal of the Optical Society of America A, 29, 2469–2478 download
Chang AM, Santhi N, St Hilaire M, Gronfier C, Bradstreet DS, Duffy JF, Lockley SW, Kronauer RE, Czeisler CA (2012) Human responses to bright light of different durations. J Physiol, 590 (Pt 13):3103-12
Daneault V, Vandewalle G, Hébert M, Teikari P, Mure LS, Doyon J, Gronfier C, Cooper HM, Dumont M, Carrier J (2012) Does pupil constriction under blue and green monochromatic light exposure change with age? J Biol Rhythms, 27(3):257-64.
Klerman H, St Hilaire MA, Kronauer RE, Gooley JJ, Gronfier C, Hull JT, Lockley SW, Santhi N, Wang W, Klerman EB (2012) Analysis method and experimental conditions affect computed circadian phase from melatonin data. PLoS One, 7(4):e33836
Duffy JF, Cain SW, Chang AM, Phillips AJK, Münch MY, Gronfier C, Wyatt JK, Dijk DJ, Wright Jr KP, Czeisler CA (2011) Sex difference in the near-24-hour intrinsic period of the human circadian timing system doi: 10.1073/pnas.1010666108 download
Vezoli J, Fifel K, Leviel V, Dehay C, Kennedy H, Cooper HM, Gronfier C, Procyk E (2011) Early Presymptomatic and Long-Term Changes of Rest Activity Cycles and Cognitive Behavior in a MPTP-Monkey Model of Parkinson’s Disease. PLoS One, 2011, 6(8):e23952 download
Renard E,Palombi K, Gronfier C, Pepin JL, Neol C, Chiquet C, Romanet JP (2010) 24-hour (nyctohemeral) rhythm of intraocular pressure and ocular perfusion pressure in normal tension glaucoma patients. IOVS 51(2):882-9
Gronfier C, Klerman EB. (2008) Sleep - endocrine changes, Chapitre “Biological Rhythms and Sleep" Encyclopedic Reference of Neuroscience, Springer, invited contribution
Gronfier C, Chneiweiss, L (2008) En finir avec le blues de l'hiver et les troubles du rythme veille-sommeil Editions Marabout/Hachette
Dkhissi-Benyahya O, Gronfier C, De Vanssay W, Flamant F, Cooper HM (2007) Modeling the role of mid-wavelength cones in circadian responses to light. Neuron 53(5):677-87. download
Gronfier C, Wright KP Jr, Kronauer RE, Czeisler CA (2007) Entrainment of the human circadian pacemaker to longer-than-24-h days. Proc Natl Acad Sci U S A, 104(21):9081-6 download
St Hilaire MA, Gronfier C, Zeitzer JM, Klerman EB (2007) A physiologically based mathematical model of melatonin including ocular light suppression and interactions with the circadian pacemaker J Pineal Res 43(3): 294-304 download
Gronfier C, Adrien J, Royant-Parola S (2007) Les mécanismes du sommeil : rythmes et pathologies Editions Le Pommier, Cité des Sciences et de l’Industrie
Gronfier C (2007) Le sommeil et les rythmes biologiques : Effets de la maladie de Parkinson. Le Parkinsonien Indépendant N°30
Neumane S, Vezoli J, Cooper HM, Procyk E, Kennedy H, Gronfier C (2007) Sleep and biological rythms disorders: early markers of Parkinson's Disease Eur J Med Res 12(4): 75
Miller MW, Gronfier C. (2006) Diurnal variation of the startle reflex in relation to HPA-axis activity in humans Psychophysiology 43(3): 297-301 download
Wright KP, Gronfier C, Duffy JF, Czeisler CA. (2005) Intrinsic period and light intensity determine the phase relationship between melatonin and sleep in humans J Biol Rhythms
Gronfier C, Wright KP, Jewett ME, Kronauer RE, Czeisler CA (2004) Efficacy of a single sequence of intermittent bright light pulses for delaying circadian phase in humans. Am J Physiol Endocrinol Metab, 287:E174-E181. download
Chapotot F, Buguet A, Gronfier C, Brandenberger G (2001) Hypothalamo-pituitary-adrenal axis activity is related to the level of central arousal: effect of sleep deprivation on the association of high-frequency waking electroencephalogram with cortisol release. Neuroendocrinology 73:312-321
Charloux A, Gronfier C, Chapotot F, Ehrhart J, Piquard F, Brandenberger G (2001) Sleep deprivation blunts the nighttime increase in aldostrone release in humans. J Sleep Res 10:27-33
Brandenberger G, Gronfier C, Chapotot F, Simon C, Piquard F (2000) Effect of sleep deprivation on overall 24h growth hormone secretion Lancet suppl download
Ehrhart J, Toussaint M, Simon C, Gronfier C, Luthringer R, Brandenberger G (2000) Alpha activity in relation to cardiac correlates differentiates the states of sleep and awakenings in humans. Clin Neurophysiol 111(5):940-6.
Gronfier C, Simon C, Piquard F, Ehrhart J, Brandenberger G (1999) Neuroendocrine processes underlying ultradian sleep regulation in man. J Clin Endocrinol Metab 84:2686-90 download
Charloux A, Gronfier C, Lonsdorfer-Wolf E, Piquard F, Brandenberger G (1999) Aldosterone release and the sleep-wake cycle in humans. Am J Physiol (Endocrinol Metab) 276:43-9. download
Chapotot F, Gronfier C, Jouny C, Buguet A, Brandenberger G (1998) Cortisol secretion is related to electroencephalographic alertness in Human subjects during daytime wakefulness. J Clin Endocrinol Metab 83:4263-8. download
Otzenberger H, Gronfier C, Charloux A, Ehrarht J, Piquard F, Brandenberger G. (1998) Dynamic heart variability: a tool for exploring the sympatho-vagal balance continuously: during sleep in man Am J Physiol (Heart Circul Physiol 44) 275: H946-H950 download
Gronfier C, Brandenberger G (1998) Ultradian rhythms in pituitary and adrenal hormones: their relations to sleep. Sleep Med Rev 2:17-29. download
Simon C, Gronfier C, Goichot B, Schlienger Jl, Brandenberger G. (1998) Circadian and ultradian variation of leptin in normal mn under continuous enteral nutrition: relationship to sleep and body temperature. J Clin Endocr Metab 83:1893-9.
Gronfier C, Chapotot F, Weibel L, Jouny C, Piquard F, Brandenberger G. (1998) Pulsatile cortisol secretion and EEG delta waves are controlled by two independent but synchronized generators. Am J Physiol (Endocrinol Metab) 275:E94-100. download
Goichot B, Weibel L, Chapotot F, Gronfier C, Brandenberger G (1998) Effect of the shift of the sleep-wake cycle on: studies on three robust endocrine markers of the circadian clock. Am J Physiol (Endocrinol Metab) 275:E243-8. download
Gronfier C, Brandenberger G, Chapotot F, Weibel L, Jouny C, Follenius M (1998) Cortisol pulsatility and delta wave activity during sleep in man Touitou Y, ed. Amsterdam: Elsevier Science BV, 577-80.
Goichot B, Weibel L, Chapotot F, Gronfier C, Brandenberger G (1998) Effect of an abrupt sleep shift on the 24-hour TSH rhythm: comparison with other markers of the circadian clock. Touitou Y, ed. Amsterdam: Elsevier Science BV, 243-6.
Charloux A, Otzenberger H, Gronfier C, Lonsdorfer-Wolf E, Piquard F, Brandenberger G (1998) Oscillations in sympathovagal balance oppose variations in delta-wave activity and the associated renin release. J Clin Endocrinol Metab 83:1523-28.
Brandenberger G, Luthringer R, Gronfier C, Macher JP (1998) Pulsatile hormone release and electroencephalographic activity during sleep in humans In: Macher JP, Crocq MA, Nedelec JF, eds. The Bio-Clinical Interface. Montrouge, France: John Libbey Eurotext,
Brandenberger G, Charloux A, Gronfier C, Otzenberger H (1998) Ultradian rhythms in hydromineral hormones. Horm Res 49:131-5. download
Brandenberger G, Gronfier C, Weibel L, Spiegel K, Luthringer R (1997) Modulatory role of sleep on hormonal pulsatility. Hayaishi O, Inoue S, eds. Sleep and Sleep Disorders: from Molecule to Behavior. Tokyo: Academic Press, 195-8.
Charloux A, Brandenberger G, Lampert E, Chapotot F, Gronfier C, Geny B, Lonsdorfer J (1997) A moderate endurance training does not modify parathyroid function of heart transplant recipients. Eur J Appl Physiol 76:134-9.
Weibel L, Follenius M, Spiegel K, Gronfier C, Brandenberger G (1997) Growth hormone secretion in night workers Chronobiol Int 14:49-60
Otzenberger H, Simon C, Gronfier C, Brandenberger G (1997) Temporal relationship between dynamic heart rate variability and electroencephalographic activity during sleep in man. Neurosci Lett 229:173-6. download
Weibel L, Spiegel K, Gronfier C, Follenius M, Brandenberger G (1997) 24-hour melatonin and body temperature rhythms: their adaptation in night workers. Am J Physiol (Regulatory Integr Comp Physiol) 41:R948-54.
Gronfier C, Luthringer R, Follenius M, Schaltenbrand N, Macher JP, Muzet A, Brandenberger G (1997) Temporal relationships between pulsatile cortisol secretion and electroencephalographic activity during sleep in man Electroenceph clin Neurophysiol 103:405-8. download
Brandenberger G, Luthringer R, Muller G, Gronfier C, Schaltenbrand N, Macher JP, Muzet A, Follenius M (1996) 5-HT2 receptors are partially involved in the relationship between renin release and delta relative power. J Endocrinol Invest 19:556-62.
Spiegel K, Weibel L, Gronfier C, Brandenberger G, Follenius M (1996) Twenty-four hour prolactin profile in night workers. Chronobiol. Int 13:283-93
Chapotot F, Gronfier C, Spiegel K, Luthringer R, Brandenberger G (1996) Relationships between iPTH 24-hour profiles, sleep-wake cycle and sleep electroencephalographic activity in man. J Clin Endocrinol Metab 81:3759-65
Gronfier C, Luthringer R, Follenius M, Schaltenbrand N, Macher JP, Muzet A, Brandenberger G (1996) A quantitative evaluation of the relationships between growth hormone secretion and delta wave electroencephalographic activity during normal sleep and after enrichment in delta waves. Sleep 19:817-24.
Gronfier C, Luthringer R, Follenius M, Schaltenbrand N, Macher JP, Muzet A, Brandenberger G (1995) Temporal link between plasma thyrotropin levels and electroencephalographic activity in man. Neurosci Lett 200:97-100 download
Follenius M, Spiegel K, Gronfier C, Saini J, Brandenberger G (1994) Clomipramine-induced sleep disturbance does not impair its prolactin-releasing action. J Endocrinol Invest 17:417-23.